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Aire-expressing ILC3-like cells in the lymph node display potent APC features
T. Yamano, J. Dobeš, M. Vobořil, M. Steinert, T. Brabec, N. Ziętara, M. Dobešová, C. Ohnmacht, M. Laan, P. Peterson, V. Benes, R. Sedláček, R. Hanayama, M. Kolář, L. Klein, D. Filipp,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1896 to 6 months ago
Europe PubMed Central
from 1896 to 6 months ago
Open Access Digital Library
from 1896-01-01
Open Access Digital Library
from 1896-01-01
Open Access Digital Library
from 1996-01-01
PubMed
30918005
DOI
10.1084/jem.20181430
Knihovny.cz E-resources
- MeSH
- Epithelial Cell Adhesion Molecule metabolism MeSH
- Antigen-Presenting Cells immunology MeSH
- CD11 Antigens metabolism MeSH
- Phenotype MeSH
- Transcription, Genetic MeSH
- Nuclear Receptor Subfamily 1, Group F, Member 3 metabolism MeSH
- Lymph Nodes cytology MeSH
- Lymphocytes immunology metabolism MeSH
- Histocompatibility Antigens Class II metabolism MeSH
- Mice, Inbred BALB C MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Immunity, Innate MeSH
- Gene Expression Regulation MeSH
- Transcription Factors genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the "promiscuous" expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of "classical" hematopoietic lineage markers, and dependence on RORγt. Aire+ cells are more frequent among lineage-negative RORγt+ cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory molecules, and efficiently present an endogenously expressed model antigen to CD4+ T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.
Helmholtz Zentrum München Institut für Allergieforschung Neuherberg Germany
Institute for Immunology Faculty of Medicine Ludwig Maximilans Universität Munich Germany
Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia
References provided by Crossref.org
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- $a The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the "promiscuous" expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of "classical" hematopoietic lineage markers, and dependence on RORγt. Aire+ cells are more frequent among lineage-negative RORγt+ cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory molecules, and efficiently present an endogenously expressed model antigen to CD4+ T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.
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