-
Something wrong with this record ?
The Lymphoma-Associated Macrophage to Hodgkin-Reed-Sternberg Cell Ratio Is a Poor Prognostic Factor in Classic Hodgkin Lymphoma Patients
V. Procházka, T. Papajík, T. Dýšková, M. Dihel, S. Brychtová, Z. Prouzová, E. Kriegová, M. Lukášová, V. Hanáčková,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Ki-1 Antigen metabolism MeSH
- Antigens, Differentiation, Myelomonocytic metabolism MeSH
- Biopsy methods MeSH
- Reed-Sternberg Cells pathology MeSH
- Antigens, CD metabolism MeSH
- Adult MeSH
- Hodgkin Disease drug therapy metabolism pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Recurrence, Local MeSH
- Lymph Nodes pathology MeSH
- Macrophages pathology MeSH
- Adolescent MeSH
- Young Adult MeSH
- Disease-Free Survival MeSH
- Prognosis MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Despite the relatively high rate of curability, approximately 20% to 30% of patients with classic Hodgkin lymphoma relapse. Hodgkin-Reed-Sternberg (HRS) cells:lymphoma-associated macrophages (LAMs) cross talk promotes tumor growth and resistance to therapy. The aim of the study was to assess the prognostic role of the LAM to HRS ratio (LHR) in lymph node biopsies using a novel automated system for scanning large sample areas. PATIENTS AND METHODS: High-quality tissue samples obtained from 71 patients and stained with anti-CD30 and anti-CD68 were analyzed using the TissueFAXS (TissueGnostics). RESULTS: A high LHR was associated with inferior 5-year progression-free survival (PFS; 50.0% vs. 79.3%; P = .032) and overall survival (OS; 65.4% vs. 92.3%; P = .012). Multivariate Cox regression identified the high LHR as an unfavorable prognostic factor for PFS (hazard ratio [HR], 3.07; P = .029) and OS (HR, 4.56; P = .025). CONCLUSION: A high LHR at diagnosis is associated with a higher risk of lymphoma progression or death. Automated image analysis is a new tool that can overcome technical limitations of by microarray samples in lymphomas with high intratumor heterogeneity.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20025601
- 003
- CZ-PrNML
- 005
- 20201222155309.0
- 007
- ta
- 008
- 201125s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.clml.2019.07.001 $2 doi
- 035 __
- $a (PubMed)31377208
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Procházka, Vít $u Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic. Electronic address: vit.prochazka@fnol.cz.
- 245 14
- $a The Lymphoma-Associated Macrophage to Hodgkin-Reed-Sternberg Cell Ratio Is a Poor Prognostic Factor in Classic Hodgkin Lymphoma Patients / $c V. Procházka, T. Papajík, T. Dýšková, M. Dihel, S. Brychtová, Z. Prouzová, E. Kriegová, M. Lukášová, V. Hanáčková,
- 520 9_
- $a BACKGROUND: Despite the relatively high rate of curability, approximately 20% to 30% of patients with classic Hodgkin lymphoma relapse. Hodgkin-Reed-Sternberg (HRS) cells:lymphoma-associated macrophages (LAMs) cross talk promotes tumor growth and resistance to therapy. The aim of the study was to assess the prognostic role of the LAM to HRS ratio (LHR) in lymph node biopsies using a novel automated system for scanning large sample areas. PATIENTS AND METHODS: High-quality tissue samples obtained from 71 patients and stained with anti-CD30 and anti-CD68 were analyzed using the TissueFAXS (TissueGnostics). RESULTS: A high LHR was associated with inferior 5-year progression-free survival (PFS; 50.0% vs. 79.3%; P = .032) and overall survival (OS; 65.4% vs. 92.3%; P = .012). Multivariate Cox regression identified the high LHR as an unfavorable prognostic factor for PFS (hazard ratio [HR], 3.07; P = .029) and OS (HR, 4.56; P = .025). CONCLUSION: A high LHR at diagnosis is associated with a higher risk of lymphoma progression or death. Automated image analysis is a new tool that can overcome technical limitations of by microarray samples in lymphomas with high intratumor heterogeneity.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a CD antigeny $x metabolismus $7 D015703
- 650 _2
- $a antigeny diferenciační myelomonocytární $x metabolismus $7 D015214
- 650 _2
- $a protokoly protinádorové kombinované chemoterapie $x terapeutické užití $7 D000971
- 650 _2
- $a biopsie $x metody $7 D001706
- 650 _2
- $a přežití bez známek nemoci $7 D018572
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a Hodgkinova nemoc $x farmakoterapie $x metabolismus $x patologie $7 D006689
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a antigen Ki-1 $x metabolismus $7 D017730
- 650 _2
- $a lymfatické uzliny $x patologie $7 D008198
- 650 _2
- $a makrofágy $x patologie $7 D008264
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a lokální recidiva nádoru $7 D009364
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a buňky Reedové-Sternberga $x patologie $7 D016539
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Papajík, Tomáš $u Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic.
- 700 1_
- $a Dýšková, Tereza $u Department of Immunology (OLGEN), Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic.
- 700 1_
- $a Dihel, Martin $u Department of Immunology (OLGEN), Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic.
- 700 1_
- $a Brychtová, Světlana $u Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.
- 700 1_
- $a Prouzová, Zuzana $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
- 700 1_
- $a Kriegová, Eva $u Department of Immunology (OLGEN), Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic.
- 700 1_
- $a Lukášová, Marie $u Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic.
- 700 1_
- $a Hanáčková, Veronika $u Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic.
- 773 0_
- $w MED00180199 $t Clinical lymphoma, myeloma & leukemia $x 2152-2669 $g Roč. 19, č. 10 (2019), s. e573-e580
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31377208 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201222155305 $b ABA008
- 999 __
- $a ok $b bmc $g 1599746 $s 1116287
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 19 $c 10 $d e573-e580 $e 20190705 $i 2152-2669 $m Clinical lymphoma, myeloma & leukemia $n Clin Lymphoma Myeloma Leuk $x MED00180199
- LZP __
- $a Pubmed-20201125
