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Mannitol treatment is not effective in therapy of rabies virus infection in mice
L. Dufkova, J. Sirmarova, J. Salat, V. Honig, M. Palus, D. Ruzek, AR. Fooks, KL. Mansfield, N. Tordo, D. Jochmans, J. Neyts, B. Martina, P. Koraka, ADME. Osterhaus, ASKLEPIOS consortium,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 2002-01-01 to 2 months ago
Nursing & Allied Health Database (ProQuest)
from 2002-01-01 to 2 months ago
Health & Medicine (ProQuest)
from 2002-01-01 to 2 months ago
Family Health Database (ProQuest)
from 2002-01-01 to 2 months ago
Health Management Database (ProQuest)
from 2002-01-01 to 2 months ago
Public Health Database (ProQuest)
from 2002-01-01 to 2 months ago
- MeSH
- Antigens, Viral metabolism MeSH
- Central Nervous System drug effects metabolism MeSH
- Blood-Brain Barrier drug effects metabolism MeSH
- Mannitol therapeutic use MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Antibodies, Viral metabolism MeSH
- Rabies virus drug effects pathogenicity MeSH
- Rabies drug therapy virology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice.
Animal and Plant Health Agency Woodham Lane New Haw Surrey KT15 3NB UK
Artemis One Health Research Institute Molengraaffsingel 10 2629 JD Delft The Netherlands
Department of Virology Veterinary Research Institute Hudcova 70 CZ 62100 Brno Czech Republic
Institut Pasteur de Guinée Gamal Abdel Nasser University Conakry Guinea
Unit Antiviral Strategies Institut Pasteur 25 Rue du Dr Roux 75724 Paris Cedex 15 France
Viroscience Lab Erasmus Medical Center P O Box 2040 Ee1726 3000 CA Rotterdam The Netherlands
References provided by Crossref.org
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- $a Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice.
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