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Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease
E. Mezeiova, K. Chalupova, E. Nepovimova, L. Gorecki, L. Prchal, D. Malinak, K. Kuca, O. Soukup, J. Korabecny,
Current Alzheimer research.
2019 ;
16 (9) :
772-800.
[pub] -
Jazyk angličtina Země Spojené arabské emiráty
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Perzistentní odkaz
https://www.medvik.cz/link/bmc20025972
- MeSH
- acetylcholinesterasa metabolismus MeSH
- Alzheimerova nemoc farmakoterapie metabolismus MeSH
- amyloidní beta-protein metabolismus MeSH
- cholinesterasové inhibitory farmakologie terapeutické užití MeSH
- donepezil analogy a deriváty MeSH
- lidé MeSH
- patologická konformace proteinů farmakoterapie metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Alzheimer's Disease (AD) is a neurodegenerative disorder with an increasing impact on society. Because currently available therapy has only a short-term effect, a huge number of novel compounds are developed every year exploiting knowledge of the various aspects of AD pathophysiology. To better address the pathological complexity of AD, one of the most extensively pursued strategies by medicinal chemists is based on Multi-target-directed Ligands (MTDLs). Donepezil is one of the currently approved drugs for AD therapy acting as an acetylcholinesterase inhibitor. In this review, we have made an extensive literature survey focusing on donepezil-derived MTDL hybrids primarily targeting on different levels cholinesterases and amyloid beta (Aβ) peptide. The targeting includes direct interaction of the compounds with Aβ, AChE-induced Aβ aggregation, inhibition of BACE-1 enzyme, and modulation of biometal balance thus impeding Aβ assembly.
Citace poskytuje Crossref.org
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