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Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Exposure-Response Analysis of 14 Case-Control Studies
C. Ge, S. Peters, A. Olsson, L. Portengen, J. Schüz, J. Almansa, W. Ahrens, V. Bencko, S. Benhamou, P. Boffetta, B. Bueno-de-Mesquita, N. Caporaso, D. Consonni, P. Demers, E. Fabiánová, G. Fernández-Tardón, J. Field, F. Forastiere, L. Foretova,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1997-07-01 do Před 1 rokem
Freely Accessible Science Journals
od 1997 do Před 1 rokem
Open Access Digital Library
od 1998-01-01
- MeSH
- adenokarcinom plic epidemiologie MeSH
- dospělí MeSH
- inhalační expozice MeSH
- kouření cigaret epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- malobuněčný karcinom epidemiologie MeSH
- nádory plic epidemiologie MeSH
- odds ratio MeSH
- pracovní expozice statistika a číselné údaje MeSH
- senioři MeSH
- sexuální faktory MeSH
- spinocelulární karcinom epidemiologie MeSH
- uhlík MeSH
- velkobuněčný karcinom epidemiologie MeSH
- výfukové emise vozidel * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
- Kanada MeSH
Rationale: Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes.Objectives: We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations.Methods: We used a quantitative EC job-exposure matrix for exposure assessment. Unconditional logistic regression models were used to calculate lung cancer odds ratios and 95% confidence intervals (CIs) associated with various metrics of EC exposure. Lung cancer excess lifetime risks (ELR) were calculated using life tables accounting for all-cause mortality. Additional stratified analyses by smoking history and lung cancer subtypes were performed in men.Measurements and Main Results: Our study included 16,901 lung cancer cases and 20,965 control subjects. In men, exposure response between EC and lung cancer was observed: odds ratios ranged from 1.09 (95% CI, 1.00-1.18) to 1.41 (95% CI, 1.30-1.52) for the lowest and highest cumulative exposure groups, respectively. EC-exposed men had elevated risks in all lung cancer subtypes investigated; associations were strongest for squamous and small cell carcinomas and weaker for adenocarcinoma. EC lung cancer exposure response was observed in men regardless of smoking history, including in never-smokers. ELR associated with 45 years of EC exposure at 50, 20, and 1 μg/m3 were 3.0%, 0.99%, and 0.04%, respectively, for both sexes combined.Conclusions: We observed a consistent exposure-response relationship between EC exposure and lung cancer in men. Reduction of workplace EC levels to background environmental levels will further reduce lung cancer ELR in exposed workers.
Consiglio Nazionale delle Ricerche Istituto per la Ricerca e l'Innovazione Biomedica Palermo Italy
Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada
Epidemiology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Faculty of Health Sciences Palacky University Olomouc Czech Republic
INSERM U 1018 Villejuif France
Institut national de la recherche scientifique University of Quebec Laval Quebec Canada
Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands
International Agency for Research on Cancer Lyon France
Leibniz Institute for Prevention Research and Epidemiology BIPS Bremen Germany
Masaryk Memorial Cancer Institute Brno Czech Republic
National Cancer Institute Bethesda Maryland
National Institute of Public Health Bucharest Romania
National Public Health Center Budapest Hungary
Occupational Cancer Research Centre Cancer Care Ontario Toronto Ontario Canada
Russian Cancer Research Centre Moscow Russia
The Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
The M Sklodowska Curie National Research Institute of Oncology Warsaw Poland
The National Institute for Public Health and Environmental Protection Bilthoven the Netherlands
The Nofer Institute of Occupational Medicine Lodz Poland
Univ Rennes Inserm Ecole des hautes études en santé publique UMR_S 1085 Pointe à Pitre France
University of Montreal Hospital Research Centre University of Montreal Montreal Quebec Canada
Citace poskytuje Crossref.org
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