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Respirable Crystalline Silica Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Analysis of Case-Control Studies
C. Ge, S. Peters, A. Olsson, L. Portengen, J. Schüz, J. Almansa, T. Behrens, B. Pesch, B. Kendzia, W. Ahrens, V. Bencko, S. Benhamou, P. Boffetta, B. Bueno-de-Mesquita, N. Caporaso, D. Consonni, P. Demers, E. Fabiánová, G. Fernández-Tardón, J....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1997-07-01 do Před 1 rokem
Freely Accessible Science Journals
od 1997 do Před 1 rokem
Open Access Digital Library
od 1998-01-01
- MeSH
- adenokarcinom plic epidemiologie MeSH
- dospělí MeSH
- inhalační expozice MeSH
- kouření cigaret MeSH
- lidé středního věku MeSH
- lidé MeSH
- malobuněčný karcinom epidemiologie MeSH
- nádory plic epidemiologie patologie MeSH
- oxid křemičitý * MeSH
- pracovní expozice statistika a číselné údaje MeSH
- senioři MeSH
- silikóza epidemiologie MeSH
- spinocelulární karcinom epidemiologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
- Kanada MeSH
Rationale: Millions of workers around the world are exposed to respirable crystalline silica. Although silica is a confirmed human lung carcinogen, little is known regarding the cancer risks associated with low levels of exposure and risks by cancer subtype. However, little is known regarding the disease risks associated with low levels of exposure and risks by cancer subtype.Objectives: We aimed to address current knowledge gaps in lung cancer risks associated with low levels of occupational silica exposure and the joint effects of smoking and silica exposure on lung cancer risks.Methods: Subjects from 14 case-control studies from Europe and Canada with detailed smoking and occupational histories were pooled. A quantitative job-exposure matrix was used to estimate silica exposure by occupation, time period, and geographical region. Logistic regression models were used to estimate exposure-disease associations and the joint effects of silica exposure and smoking on risk of lung cancer. Stratified analyses by smoking history and cancer subtypes were also performed.Measurements and Main Results: Our study included 16,901 cases and 20,965 control subjects. Lung cancer odds ratios ranged from 1.15 (95% confidence interval, 1.04-1.27) to 1.45 (95% confidence interval, 1.31-1.60) for groups with the lowest and highest cumulative exposure, respectively. Increasing cumulative silica exposure was associated (P trend < 0.01) with increasing lung cancer risks in nonsilicotics and in current, former, and never-smokers. Increasing exposure was also associated (P trend ≤ 0.01) with increasing risks of lung adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. Supermultiplicative interaction of silica exposure and smoking was observed on overall lung cancer risks; superadditive effects were observed in risks of lung cancer and all three included subtypes.Conclusions: Silica exposure is associated with lung cancer at low exposure levels. An exposure-response relationship was robust and present regardless of smoking, silicosis status, and cancer subtype.
Consiglio Nazionale delle Ricerche Istituto per la Ricerca e l'Innovazione Biomedica Palermo Italy
Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada
Faculty of Health Sciences Palacky University Olomouc Czech Republic
Inserm Unit 1018 Villejuif France
Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands
International Agency for Research on Cancer Lyon France
Masaryk Memorial Cancer Institute Brno Czech Republic
National Cancer Institute Bethesda Maryland
National Institute of Public Health Bucharest Romania
National Public Health Center Budapest Hungary
Occupational Cancer Research Centre Cancer Care Ontario Toronto Ontario Canada
Russian Cancer Research Centre Moscow Russia
The Institute of Environmental Medicine Karolinska Institute Stockholm Sweden
The M Sklodowska Curie National Research Institute of Oncology Warsaw Poland
The National Institute for Public Health and Environmental Protection Bilthoven the Netherlands
The Nofer Institute of Occupational Medicine Lodz Poland
Unità di epidemiologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
University of Montreal Hospital Research Centre University of Montreal Montreal Quebec Canada
Citace poskytuje Crossref.org
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- $a Respirable Crystalline Silica Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Analysis of Case-Control Studies / $c C. Ge, S. Peters, A. Olsson, L. Portengen, J. Schüz, J. Almansa, T. Behrens, B. Pesch, B. Kendzia, W. Ahrens, V. Bencko, S. Benhamou, P. Boffetta, B. Bueno-de-Mesquita, N. Caporaso, D. Consonni, P. Demers, E. Fabiánová, G. Fernández-Tardón, J. Field, F. Forastiere, L. Foretova, P. Guénel, P. Gustavsson, V. Ho, V. Janout, KH. Jöckel, S. Karrasch, MT. Landi, J. Lissowska, D. Luce, D. Mates, J. McLaughlin, F. Merletti, D. Mirabelli, N. Plato, H. Pohlabeln, L. Richiardi, P. Rudnai, J. Siemiatycki, B. Świątkowska, A. Tardón, HE. Wichmann, D. Zaridze, T. Brüning, K. Straif, H. Kromhout, R. Vermeulen,
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- $a Rationale: Millions of workers around the world are exposed to respirable crystalline silica. Although silica is a confirmed human lung carcinogen, little is known regarding the cancer risks associated with low levels of exposure and risks by cancer subtype. However, little is known regarding the disease risks associated with low levels of exposure and risks by cancer subtype.Objectives: We aimed to address current knowledge gaps in lung cancer risks associated with low levels of occupational silica exposure and the joint effects of smoking and silica exposure on lung cancer risks.Methods: Subjects from 14 case-control studies from Europe and Canada with detailed smoking and occupational histories were pooled. A quantitative job-exposure matrix was used to estimate silica exposure by occupation, time period, and geographical region. Logistic regression models were used to estimate exposure-disease associations and the joint effects of silica exposure and smoking on risk of lung cancer. Stratified analyses by smoking history and cancer subtypes were also performed.Measurements and Main Results: Our study included 16,901 cases and 20,965 control subjects. Lung cancer odds ratios ranged from 1.15 (95% confidence interval, 1.04-1.27) to 1.45 (95% confidence interval, 1.31-1.60) for groups with the lowest and highest cumulative exposure, respectively. Increasing cumulative silica exposure was associated (P trend < 0.01) with increasing lung cancer risks in nonsilicotics and in current, former, and never-smokers. Increasing exposure was also associated (P trend ≤ 0.01) with increasing risks of lung adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. Supermultiplicative interaction of silica exposure and smoking was observed on overall lung cancer risks; superadditive effects were observed in risks of lung cancer and all three included subtypes.Conclusions: Silica exposure is associated with lung cancer at low exposure levels. An exposure-response relationship was robust and present regardless of smoking, silicosis status, and cancer subtype.
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