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Biotechnological applications of nanostructured hybrids of polyamine carbon quantum dots and iron oxide nanoparticles
A. Venerando, M. Magro, D. Baratella, J. Ugolotti, S. Zanin, O. Malina, R. Zboril, H. Lin, F. Vianello,
Jazyk angličtina Země Rakousko
Typ dokumentu časopisecké články
Grantová podpora
DOR1872491
Italian Institutional Ministry
LO1204
Ministerstvo Školství, Mládeže a Tělovýchovy
NLK
ProQuest Central
od 1997-03-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2010-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-03-01 do Před 1 rokem
- MeSH
- biotechnologie MeSH
- fluorescence MeSH
- HeLa buňky MeSH
- kvantové tečky chemie metabolismus MeSH
- lidé MeSH
- nanostruktury chemie MeSH
- polyaminy chemie metabolismus MeSH
- statická elektřina MeSH
- uhlík chemie metabolismus MeSH
- železité sloučeniny chemie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The combination of different nanomaterials has been investigated during the past few decades and represents an exciting challenge for the unexpected emerging properties of the resulting nano-hybrids. Spermidine (Spd), a biogenic polyamine, has emerged as a useful functional monomer for the development of carbon quantum dots (CQDs). Herein, an electrostatically stabilized ternary hybrid, constituted of iron oxide-DNA (the core) and spermidine carbon quantum dots (CQDSpds, the shell), was self-assembled and fully characterized. The as-obtained nano-hybrid was tested on HeLa cells to evaluate its biocompatibility as well as cellular uptake. Most importantly, besides being endowed by the magnetic features of the core, it displayed drastically enhanced fluorescence properties in comparison with parent CQDSpds and it is efficiently internalized by HeLa cells. This novel ternary nano-hybrid with multifaceted properties, ranging from fluorescence to superparamagnetism, represents an interesting option for cell tracking.
Department of Bioscience and Biotechnology National Taiwan Ocean University 20224 Keelung Taiwan
Department of Medicine University of Padua Via Giustiniani 2 35128 Padua Italy
Citace poskytuje Crossref.org
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- $a The combination of different nanomaterials has been investigated during the past few decades and represents an exciting challenge for the unexpected emerging properties of the resulting nano-hybrids. Spermidine (Spd), a biogenic polyamine, has emerged as a useful functional monomer for the development of carbon quantum dots (CQDs). Herein, an electrostatically stabilized ternary hybrid, constituted of iron oxide-DNA (the core) and spermidine carbon quantum dots (CQDSpds, the shell), was self-assembled and fully characterized. The as-obtained nano-hybrid was tested on HeLa cells to evaluate its biocompatibility as well as cellular uptake. Most importantly, besides being endowed by the magnetic features of the core, it displayed drastically enhanced fluorescence properties in comparison with parent CQDSpds and it is efficiently internalized by HeLa cells. This novel ternary nano-hybrid with multifaceted properties, ranging from fluorescence to superparamagnetism, represents an interesting option for cell tracking.
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