Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Substituted Piperazines as Novel Potential Radioprotective Agents

A. Filipova, J. Marek, R. Havelek, J. Pejchal, M. Jelicova, J. Cizkova, M. Majorosova, L. Muckova, T. Kucera, L. Prchal, M. Psotka, N. Zivna, D. Koutova, Z. Sinkorova, M. Rezacova, A. Tichy,

. 2020 ; 25 (3) : . [pub] 20200125

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028585

Grantová podpora
17-13541S Grantová Agentura České Republiky

The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radiation-induced apoptosis and exhibited low cytotoxicity. Compared to the previous series of piperazine derivatives, compound 8 exhibited a radioprotective effect on cell survival in vitro and low toxicity in vivo. It also enhanced the survival of mice 30 days after whole-body irradiation (although this increase was not statistically significant). Taken together, our in vitro and in vivo data indicate that some of our compounds are valuable for further research as potential radioprotectors.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20028585
003      
CZ-PrNML
005      
20221101094404.0
007      
ta
008      
210105s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/molecules25030532 $2 doi
035    __
$a (PubMed)31991816
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Filipova, Alzbeta $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
245    10
$a Substituted Piperazines as Novel Potential Radioprotective Agents / $c A. Filipova, J. Marek, R. Havelek, J. Pejchal, M. Jelicova, J. Cizkova, M. Majorosova, L. Muckova, T. Kucera, L. Prchal, M. Psotka, N. Zivna, D. Koutova, Z. Sinkorova, M. Rezacova, A. Tichy,
520    9_
$a The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radiation-induced apoptosis and exhibited low cytotoxicity. Compared to the previous series of piperazine derivatives, compound 8 exhibited a radioprotective effect on cell survival in vitro and low toxicity in vivo. It also enhanced the survival of mice 30 days after whole-body irradiation (although this increase was not statistically significant). Taken together, our in vitro and in vivo data indicate that some of our compounds are valuable for further research as potential radioprotectors.
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a viabilita buněk $x účinky léků $x účinky záření $7 D002470
650    _2
$a vztah mezi dávkou a účinkem léčiva $7 D004305
650    _2
$a lidé $7 D006801
650    _2
$a maximální tolerovaná dávka $7 D020714
650    _2
$a molekulární modely $7 D008958
650    _2
$a molekulární konformace $7 D008968
650    _2
$a molekulární struktura $7 D015394
650    _2
$a piperaziny $x aplikace a dávkování $x škodlivé účinky $x chemie $x farmakologie $7 D010879
650    _2
$a ionizující záření $7 D011839
650    _2
$a radioprotektivní látky $x aplikace a dávkování $x škodlivé účinky $x chemie $x farmakologie $7 D011837
650    _2
$a vztahy mezi strukturou a aktivitou $7 D013329
650    _2
$a analýza přežití $7 D016019
655    _2
$a časopisecké články $7 D016428
700    1_
$a Marek, Jan $u Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
700    1_
$a Havelek, Radim $u Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
700    1_
$a Pejchal, Jaroslav $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
700    1_
$a Jelicova, Marcela $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
700    1_
$a Cizkova, Jana $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
700    1_
$a Majorosova, Martina $u Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
700    1_
$a Muckova, Lubica $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
700    1_
$a Kucera, Tomas $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
700    1_
$a Prchal, Lukas $u Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
700    1_
$a Psotka, Miroslav $u Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. $7 xx0277934
700    1_
$a Zivna, Natalie $u Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
700    1_
$a Koutova, Darja $u Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
700    1_
$a Sinkorova, Zuzana $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
700    1_
$a Rezacova, Martina $u Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
700    1_
$a Tichy, Ales $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence in Brno, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
773    0_
$w MED00180394 $t Molecules $x 1420-3049 $g Roč. 25, č. 3 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31991816 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20210105 $b ABA008
991    __
$a 20221101094400 $b ABA008
999    __
$a ok $b bmc $g 1608920 $s 1119765
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 25 $c 3 $e 20200125 $i 1420-3049 $m Molecules $n Molecules $x MED00180394
GRA    __
$a 17-13541S $p Grantová Agentura České Republiky
LZP    __
$a Pubmed-20210105

Najít záznam

Citační ukazatele

Možnosti archivace