• Je něco špatně v tomto záznamu ?

Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in home parenteral nutrition patients: a crossover study

F. Novak, M. Vecka, E. Meisnerova, S. Sevela, L. Vavrova, J. Rychlikova, L. Dolezalova, D. Myslivcova, A. Zak, L. Vitek, O. Novakova,

. 2019 ; 72 (-) : 70-79. [pub] 20191023

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, randomizované kontrolované studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028738

Long-chain n-3 polyunsaturated fatty acids modulate immune cell functions. The primary objective of this study was to evaluate the impact of different lipid emulsions (LEs) with supplemented doses of fish oil (FO) on serum cytokine concentration and in vitro cytokine production in patients with intestinal failure on home parenteral nutrition (HPNPs). We hypothesized that FO supplementation would diminish lipopolysaccharide (LPS)-stimulated cytokine production. Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. After this cycle, the patients were randomized to subsequently receive 1 cycle with Lipoplus and 1 cycle with ClinOleic for 6 weeks or vice versa plus 4 weeks of added Omegaven after each cycle in a crossover design. Comparison of the baseline LE regimens showed lower LPS-stimulated production of IL-1β in the HPNPs on Lipoplus than on the Smoflipid and ClinOleic regimens, as well as lower IL-8 compared to the Smoflipid regimen. Omegaven reduced IL-8 concentration in serum under the Lipoplus regimen and diminished LPS-stimulated production of IL-1β under the Smoflipid and ClinOleic. IL-6 and TNF-α production was depressed only in those on Smoflipid. Irrespective of the LE used, the HPNPs compared to the healthy controls showed higher IL-6, IL-8, and TNF-α concentrations in serum and LPS-stimulated production of IL-6 as well as lower n-6/n-3 long-chain polyunsaturated fatty acids in the erythrocyte phospholipids. LPS-stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. In conclusion, FO-supplemented parenteral nutrition suppresses in vitro cytokine production.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20028738
003      
CZ-PrNML
005      
20210114154926.0
007      
ta
008      
210105s2019 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.nutres.2019.10.004 $2 doi
035    __
$a (PubMed)31759770
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Novak, Frantisek $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic. Electronic address: fnova@lf1.cuni.cz.
245    10
$a Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in home parenteral nutrition patients: a crossover study / $c F. Novak, M. Vecka, E. Meisnerova, S. Sevela, L. Vavrova, J. Rychlikova, L. Dolezalova, D. Myslivcova, A. Zak, L. Vitek, O. Novakova,
520    9_
$a Long-chain n-3 polyunsaturated fatty acids modulate immune cell functions. The primary objective of this study was to evaluate the impact of different lipid emulsions (LEs) with supplemented doses of fish oil (FO) on serum cytokine concentration and in vitro cytokine production in patients with intestinal failure on home parenteral nutrition (HPNPs). We hypothesized that FO supplementation would diminish lipopolysaccharide (LPS)-stimulated cytokine production. Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. After this cycle, the patients were randomized to subsequently receive 1 cycle with Lipoplus and 1 cycle with ClinOleic for 6 weeks or vice versa plus 4 weeks of added Omegaven after each cycle in a crossover design. Comparison of the baseline LE regimens showed lower LPS-stimulated production of IL-1β in the HPNPs on Lipoplus than on the Smoflipid and ClinOleic regimens, as well as lower IL-8 compared to the Smoflipid regimen. Omegaven reduced IL-8 concentration in serum under the Lipoplus regimen and diminished LPS-stimulated production of IL-1β under the Smoflipid and ClinOleic. IL-6 and TNF-α production was depressed only in those on Smoflipid. Irrespective of the LE used, the HPNPs compared to the healthy controls showed higher IL-6, IL-8, and TNF-α concentrations in serum and LPS-stimulated production of IL-6 as well as lower n-6/n-3 long-chain polyunsaturated fatty acids in the erythrocyte phospholipids. LPS-stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. In conclusion, FO-supplemented parenteral nutrition suppresses in vitro cytokine production.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a klinické křížové studie $7 D018592
650    _2
$a cytokiny $x krev $7 D016207
650    _2
$a potravní doplňky $7 D019587
650    _2
$a tukové emulze intravenózní $x aplikace a dávkování $x metabolismus $x farmakologie $7 D005217
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a rybí oleje $x aplikace a dávkování $x krev $x farmakologie $7 D005395
650    _2
$a lidé $7 D006801
650    _2
$a techniky in vitro $7 D066298
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a parenterální výživa doma $x metody $7 D016331
655    _2
$a časopisecké články $7 D016428
655    _2
$a randomizované kontrolované studie $7 D016449
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vecka, Marek $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic.
700    1_
$a Meisnerova, Eva $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic.
700    1_
$a Sevela, Stanislav $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic.
700    1_
$a Vavrova, Lucie $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic.
700    1_
$a Rychlikova, Jana $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic.
700    1_
$a Dolezalova, Ludmila $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
700    1_
$a Myslivcova, Denisa $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
700    1_
$a Zak, Ales $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic.
700    1_
$a Vitek, Libor $u Charles University, 1st Faculty of Medicine and General University Hospital, Institute of Medical Biochemistry and Laboratory Diagnostics, Prague, Czech Republic.
700    1_
$a Novakova, Olga $u Charles University in Prague, Faculty of Science, Department of Physiology, Prague, Czech Republic; Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
773    0_
$w MED00008649 $t Nutrition research (New York, N.Y.) $x 1879-0739 $g Roč. 72, č. - (2019), s. 70-79
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31759770 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20210105 $b ABA008
991    __
$a 20210114154922 $b ABA008
999    __
$a ok $b bmc $g 1609073 $s 1119918
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 72 $c - $d 70-79 $e 20191023 $i 1879-0739 $m Nutrition research $n Nutr Res $x MED00008649
LZP    __
$a Pubmed-20210105

Najít záznam

Citační ukazatele

Možnosti archivace