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The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil
T. Lemos-Silva, EL. Telleria, YM. Traub-Csekö
Language English Country Brazil
Document type Journal Article
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- MeSH
- Gene Expression MeSH
- Insect Vectors parasitology MeSH
- Leishmania infantum genetics MeSH
- Leishmania isolation & purification MeSH
- Leishmaniasis, Visceral epidemiology parasitology transmission MeSH
- Reverse Transcriptase Polymerase Chain Reaction methods MeSH
- Psychodidae genetics parasitology MeSH
- Life Cycle Stages MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Brazil MeSH
Leishmania infantum chagasi is the causative agent and Lutzomyia longipalpis is the main vector of visceral leishmaniasis in the Americas. We investigated the expression of Leishmania genes within L. longipalpis after artificial infection. mRNAs from genes involved in sugar and amino acid metabolism were upregulated at times of high parasite proliferation inside the insect. mRNAs from genes involved in metacyclogenesis had higher expression in late stages of infection. Other modulated genes of interest were involved in immunomodulation, purine salvage pathway and protein recycling. These data reveal aspects of the adaptation of the parasite to the microenvironment of the vector gut and reflect the preparation for infection in the vertebrate.
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