Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T

JP. Slopsema, A. Canna, M. Uchenik, LJ. Lehto, J. Krieg, L. Wilmerding, DM. Koski, N. Kobayashi, J. Dao, M. Blumenfeld, P. Filip, HK. Min, S. Mangia, MD. Johnson, S. Michaeli

. 2021 ; 224 (-) : 117357. [pub] 20200909

Language English Country United States

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Persistent link   https://www.medvik.cz/link/bmc21011685

Grant support
P41 EB015894 NIBIB NIH HHS - United States
R01 NS094206 NINDS NIH HHS - United States
P30 NS076408 NINDS NIH HHS - United States
U01 NS103569 NINDS NIH HHS - United States
R25 NS118756 NINDS NIH HHS - United States
R01 NS081118 NINDS NIH HHS - United States
P50 NS098573 NINDS NIH HHS - United States
U54 MH091657 NIMH NIH HHS - United States

Functional MRI (fMRI) has become an important tool for probing network-level effects of deep brain stimulation (DBS). Previous DBS-fMRI studies have shown that electrical stimulation of the ventrolateral (VL) thalamus can modulate sensorimotor cortices in a frequency and amplitude dependent manner. Here, we investigated, using a swine animal model, how the direction and orientation of the electric field, induced by VL-thalamus DBS, affects activity in the sensorimotor cortex. Adult swine underwent implantation of a novel 16-electrode (4 rows x 4 columns) directional DBS lead in the VL thalamus. A within-subject design was used to compare fMRI responses for (1) directional stimulation consisting of monopolar stimulation in four radial directions around the DBS lead, and (2) orientation-selective stimulation where an electric field dipole was rotated 0°-360° around a quadrangle of electrodes. Functional responses were quantified in the premotor, primary motor, and somatosensory cortices. High frequency electrical stimulation through leads implanted in the VL thalamus induced directional tuning in cortical response patterns to varying degrees depending on DBS lead position. Orientation-selective stimulation showed maximal functional response when the electric field was oriented approximately parallel to the DBS lead, which is consistent with known axonal orientations of the cortico-thalamocortical pathway. These results demonstrate that directional and orientation-selective stimulation paradigms in the VL thalamus can tune network-level modulation patterns in the sensorimotor cortex, which may have translational utility in improving functional outcomes of DBS therapy.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21011685
003      
CZ-PrNML
005      
20210507103912.0
007      
ta
008      
210420s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.neuroimage.2020.117357 $2 doi
035    __
$a (PubMed)32916285
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Slopsema, Julia P $u Department of Biomedical Engineering, University of Minnesota
245    10
$a Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T / $c JP. Slopsema, A. Canna, M. Uchenik, LJ. Lehto, J. Krieg, L. Wilmerding, DM. Koski, N. Kobayashi, J. Dao, M. Blumenfeld, P. Filip, HK. Min, S. Mangia, MD. Johnson, S. Michaeli
520    9_
$a Functional MRI (fMRI) has become an important tool for probing network-level effects of deep brain stimulation (DBS). Previous DBS-fMRI studies have shown that electrical stimulation of the ventrolateral (VL) thalamus can modulate sensorimotor cortices in a frequency and amplitude dependent manner. Here, we investigated, using a swine animal model, how the direction and orientation of the electric field, induced by VL-thalamus DBS, affects activity in the sensorimotor cortex. Adult swine underwent implantation of a novel 16-electrode (4 rows x 4 columns) directional DBS lead in the VL thalamus. A within-subject design was used to compare fMRI responses for (1) directional stimulation consisting of monopolar stimulation in four radial directions around the DBS lead, and (2) orientation-selective stimulation where an electric field dipole was rotated 0°-360° around a quadrangle of electrodes. Functional responses were quantified in the premotor, primary motor, and somatosensory cortices. High frequency electrical stimulation through leads implanted in the VL thalamus induced directional tuning in cortical response patterns to varying degrees depending on DBS lead position. Orientation-selective stimulation showed maximal functional response when the electric field was oriented approximately parallel to the DBS lead, which is consistent with known axonal orientations of the cortico-thalamocortical pathway. These results demonstrate that directional and orientation-selective stimulation paradigms in the VL thalamus can tune network-level modulation patterns in the sensorimotor cortex, which may have translational utility in improving functional outcomes of DBS therapy.
650    _2
$a zvířata $7 D000818
650    12
$a hluboká mozková stimulace $x metody $7 D046690
650    _2
$a elektrická stimulace $x metody $7 D004558
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a magnetická rezonanční tomografie $x metody $7 D008279
650    _2
$a motorické korové centrum $x fyziologie $7 D009044
650    _2
$a nervové dráhy $x fyziologie $7 D009434
650    _2
$a nucleus subthalamicus $x fyziologie $7 D020531
650    _2
$a prasata $7 D013552
650    _2
$a thalamus $x fyziologie $7 D013788
650    _2
$a nuclei ventrales thalami $x fyziologie $7 D020651
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a Research Support, U.S. Gov't, Non-P.H.S. $7 D013486
700    1_
$a Canna, Antonietta $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota
700    1_
$a Uchenik, Michelle $u Department of Biomedical Engineering, University of Minnesota
700    1_
$a Lehto, Lauri J $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota
700    1_
$a Krieg, Jordan $u Department of Biomedical Engineering, University of Minnesota
700    1_
$a Wilmerding, Lucius $u Department of Biomedical Engineering, University of Minnesota
700    1_
$a Koski, Dee M $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota
700    1_
$a Kobayashi, Naoharu $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota
700    1_
$a Dao, Joan $u Department of Biomedical Engineering, University of Minnesota
700    1_
$a Blumenfeld, Madeline $u Department of Biomedical Engineering, University of Minnesota
700    1_
$a Filip, Pavel $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota; Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
700    1_
$a Min, Hoon-Ki $u Department of Radiology, Mayo Clinic
700    1_
$a Mangia, Silvia $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota
700    1_
$a Johnson, Matthew D $u Department of Biomedical Engineering, University of Minnesota; Institute for Translational Neuroscience, University of Minnesota
700    1_
$a Michaeli, Shalom $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota. Electronic address: shalom@cmrr.umn.edu
773    0_
$w MED00006575 $t NeuroImage $x 1095-9572 $g Roč. 224, č. - (2021), s. 117357
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32916285 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210507103911 $b ABA008
999    __
$a ok $b bmc $g 1650148 $s 1132064
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 224 $c - $d 117357 $e 20200909 $i 1095-9572 $m Neuroimage $n Neuroimage $x MED00006575
GRA    __
$a P41 EB015894 $p NIBIB NIH HHS $2 United States
GRA    __
$a R01 NS094206 $p NINDS NIH HHS $2 United States
GRA    __
$a P30 NS076408 $p NINDS NIH HHS $2 United States
GRA    __
$a U01 NS103569 $p NINDS NIH HHS $2 United States
GRA    __
$a R25 NS118756 $p NINDS NIH HHS $2 United States
GRA    __
$a R01 NS081118 $p NINDS NIH HHS $2 United States
GRA    __
$a P50 NS098573 $p NINDS NIH HHS $2 United States
GRA    __
$a U54 MH091657 $p NIMH NIH HHS $2 United States
LZP    __
$a Pubmed-20210420

Find record

Citation metrics

Archiving options