• Something wrong with this record ?

Trajectories of depressive symptoms and associated patterns of cognitive decline

T. Formánek, Z. Csajbók, K. Wolfová, M. Kučera, S. Tom, D. Aarsland, P. Cermakova

. 2020 ; 10 (1) : 20888. [pub] 20201130

Language English Country Great Britain

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21011829

Grant support
U01 AG009740 NIA NIH HHS - United States
P01 AG005842 NIA NIH HHS - United States
P01 AG008291 NIA NIH HHS - United States
P30 AG012815 NIA NIH HHS - United States
R21 AG025169 NIA NIH HHS - United States
HHSN271201300071C NIA NIH HHS - United States

The aim was to investigate the pattern and rate of cognitive decline across distinctive trajectories of depressive symptoms in older adults. In this prospective multinational cohort study on 69,066 participants (on average 64 years at baseline, 55% women), assessments of cognitive functions (immediate recall, delayed recall, verbal fluency) and depressive symptoms (EURO-D scale) were conducted at 2-year intervals. The trajectories of depressive symptoms were obtained using latent growth mixture modelling, cognitive decline was assessed using smoothing splines and linear mixed effects models. Four distinct trajectories of depressive symptoms were identified: constantly low (n = 49,660), constantly high (n = 2999), increasing (n = 6828) and decreasing (n = 9579). Individuals with increasing and constantly high depressive symptoms showed linear cognitive decline, while those with constantly low and decreasing depressive symptoms had fluctuating cognition. Participants with increasing depressive symptoms had the fastest decline, while those with decreasing symptoms were spared from decline in cognition. This study suggests that the pattern as well as the rate of cognitive decline co-occurs with specific patterns of changes in depressive symptoms over time. The most pronounced cognitive decline is present in individuals, in whom depressive symptoms increase late in life. Unique mechanisms of cognitive decline may exist for subgroups of the population, and are associated with the trajectory of depressive symptoms.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21011829
003      
CZ-PrNML
005      
20240626153648.0
007      
ta
008      
210420s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-020-77866-6 $2 doi
035    __
$a (PubMed)33257789
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Formánek, Tomáš $u National Institute of Mental Health, Klecany, Czech Republic $7 xx0319355
245    10
$a Trajectories of depressive symptoms and associated patterns of cognitive decline / $c T. Formánek, Z. Csajbók, K. Wolfová, M. Kučera, S. Tom, D. Aarsland, P. Cermakova
520    9_
$a The aim was to investigate the pattern and rate of cognitive decline across distinctive trajectories of depressive symptoms in older adults. In this prospective multinational cohort study on 69,066 participants (on average 64 years at baseline, 55% women), assessments of cognitive functions (immediate recall, delayed recall, verbal fluency) and depressive symptoms (EURO-D scale) were conducted at 2-year intervals. The trajectories of depressive symptoms were obtained using latent growth mixture modelling, cognitive decline was assessed using smoothing splines and linear mixed effects models. Four distinct trajectories of depressive symptoms were identified: constantly low (n = 49,660), constantly high (n = 2999), increasing (n = 6828) and decreasing (n = 9579). Individuals with increasing and constantly high depressive symptoms showed linear cognitive decline, while those with constantly low and decreasing depressive symptoms had fluctuating cognition. Participants with increasing depressive symptoms had the fastest decline, while those with decreasing symptoms were spared from decline in cognition. This study suggests that the pattern as well as the rate of cognitive decline co-occurs with specific patterns of changes in depressive symptoms over time. The most pronounced cognitive decline is present in individuals, in whom depressive symptoms increase late in life. Unique mechanisms of cognitive decline may exist for subgroups of the population, and are associated with the trajectory of depressive symptoms.
650    _2
$a senioři $7 D000368
650    _2
$a kognice $x fyziologie $7 D003071
650    _2
$a kognitivní dysfunkce $x patofyziologie $7 D060825
650    _2
$a deprese $x patofyziologie $x psychologie $7 D003863
650    _2
$a depresivní poruchy $x patofyziologie $7 D003866
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prospektivní studie $7 D011446
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Csajbók, Zsófia $u National Institute of Mental Health, Klecany, Czech Republic ; Third Faculty of Medicine, Charles University Prague, Ruská 87, 100 00, Prague 10, Czech Republic
700    1_
$a Wolfová, Katrin $u National Institute of Mental Health, Klecany, Czech Republic ; Third Faculty of Medicine, Charles University Prague, Ruská 87, 100 00, Prague 10, Czech Republic
700    1_
$a Kučera, Matěj $u National Institute of Mental Health, Klecany, Czech Republic ; Third Faculty of Medicine, Charles University Prague, Ruská 87, 100 00, Prague 10, Czech Republic
700    1_
$a Tom, Sarah $u Departments of Neurology and Epidemiology, Columbia University, New York, USA
700    1_
$a Aarsland, Dag $u Department of Old Age Psychiatry Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK ; Centre of Age-Related Medicine, University Hospital Stavanger, Stavanger, Norway
700    1_
$a Cermakova, Pavla $u National Institute of Mental Health, Klecany, Czech Republic. Pavla.Cermakova@nudz.cz ; Third Faculty of Medicine, Charles University Prague, Ruská 87, 100 00, Prague 10, Czech Republic. Pavla.Cermakova@nudz.cz ; Second Faculty of Medicine, Charles University, Prague, Czech Republic. Pavla.Cermakova@nudz.cz
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 10, č. 1 (2020), s. 20888
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33257789 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20240626153643 $b ABA008
999    __
$a ok $b bmc $g 1650258 $s 1132208
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 10 $c 1 $d 20888 $e 20201130 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
GRA    __
$a U01 AG009740 $p NIA NIH HHS $2 United States
GRA    __
$a P01 AG005842 $p NIA NIH HHS $2 United States
GRA    __
$a P01 AG008291 $p NIA NIH HHS $2 United States
GRA    __
$a P30 AG012815 $p NIA NIH HHS $2 United States
GRA    __
$a R21 AG025169 $p NIA NIH HHS $2 United States
GRA    __
$a HHSN271201300071C $p NIA NIH HHS $2 United States
LZP    __
$a Pubmed-20210420

Find record

Citation metrics

Archiving options