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The Role of the LINC Complex in Sperm Development and Function

V. Kmonickova, M. Frolikova, K. Steger, K. Komrskova

. 2020 ; 21 (23) : . [pub] 20201128

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc21011835

Grant support
STE 892/20-1 German Research Foundation
GA-20-20217J Grant Agency of the Czech Republic
CZ.1.05/1.1.00/02.0109 BIOCEV - Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University
86652036 Institute of Biotechnology RVO

The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic structures. While the nucleoplasm-facing side acts as a key player for correct pairing of homolog chromosomes and rapid chromosome movements during meiosis, the cytoplasm-facing side plays a pivotal role for sperm head development and proper acrosome formation during spermiogenesis. A further complex present in spermatozoa is involved in head-to-tail coupling. An intact LINC complex is crucial for the production of fertile sperm, as mutations in genes encoding for complex proteins are known to be associated with male subfertility in both mice and men. The present review provides a comprehensive overview on our current knowledge of LINC complex subtypes present in germ cells and its central role for male reproduction. Future studies on distinct LINC complex components are an absolute requirement to improve the diagnosis of idiopathic male factor infertility and the outcome of assisted reproduction.

References provided by Crossref.org

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