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Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers

V. Kincl, R. Panovský, M. Pešl, J. Máchal, L. Juříková, J. Haberlová, L. Masárová

. 2020 ; 10 (1) : 20794. [pub] 20201127

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21011840

To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.

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$a Kincl, Vladimír $u Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic. vladimir.kincl@fnusa.cz ; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. vladimir.kincl@fnusa.cz
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$a To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.
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$a Panovský, Roman $u Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic ; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
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$a Pešl, Martin $u Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic ; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic ; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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$a Máchal, Jan $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic ; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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$a Juříková, Lenka $u Department of Pediatric Neurology, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czech Republic
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$a Haberlová, Jana $u Department of Pediatric Neurology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic
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$a Masárová, Lucia $u Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic ; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
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