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Impact of discordance between patient's and evaluator's global assessment on treatment outcomes in 14 868 patients with spondyloarthritis
B. Michelsen, LM. Ørnbjerg, TK. Kvien, K. Pavelka, MJ. Nissen, D. Nordström, MJ. Santos, SS. Koca, J. Askling, Z. Rotar, B. Gudbjornsson, C. Codreanu, AG. Loft, EK. Kristianslund, HF. Mann, A. Ciurea, KK. Eklund, E. Vieira-Sousa, A. Yazici, L....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
Medline Complete (EBSCOhost)
od 1999-01-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- hodnocení výsledků zdravotní péče statistika a číselné údaje MeSH
- indukce remise MeSH
- inhibitory TNF terapeutické užití MeSH
- Kaplanův-Meierův odhad MeSH
- lidé středního věku MeSH
- lidé MeSH
- logistické modely MeSH
- longitudinální studie MeSH
- pacientův souhlas se zdravotní péčí statistika a číselné údaje MeSH
- proporcionální rizikové modely MeSH
- psoriatická artritida farmakoterapie MeSH
- registrace MeSH
- spondylartritida farmakoterapie MeSH
- stupeň závažnosti nemoci * MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
OBJECTIVES: To assess the impact of 'patient's minus evaluator's global assessment of disease activity' (ΔPEG) at treatment initiation on retention and remission rates of TNF inhibitors (TNFi) in psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) patients across Europe. METHODS: Real-life data from PsA and axSpA patients starting their first TNFi from 11 countries in the European Spondyloarthritis Research Collaboration Network were pooled. Retention rates were compared by Kaplan-Meier analyses with log-rank test and by Cox regression, and remission rates by χ2 test and by logistic regression across quartiles of baseline ΔPEG, separately in female and male PsA and axSpA patients. RESULTS: We included 14 868 spondyloarthritis (5855 PsA, 9013 axSpA) patients. Baseline ΔPEG was negatively associated with 6/12/24-months' TNFi retention rates in female and male PsA and axSpA patients (P <0.001), with 6/12/24-months' BASDAI < 2 (P ≤0.002) and ASDAS < 1.3 (P ≤0.005) in axSpA patients, and with DAS28CRP(4)<2.6 (P ≤0.04) and DAPSA28 ≤ 4 (P ≤0.01), but not DAS28CRP(3)<2.6 (P ≥0.13) in PsA patients, with few exceptions on remission rates. Retention and remission rates were overall lower in female than male patients. CONCLUSION: High baseline patient's compared with evaluator's global assessment was associated with lower 6/12/24-months' remission as well as retention rates of first TNFi in both PsA and axSpA patients. These results highlight the importance of discordance between patient's and evaluator's perspective on disease outcomes.
BioRx si and the Department of Rheumatology University Medical Centre Ljubljana Ljubljana Slovenia
Center of Rheumatic Diseases University of Medicine and Pharmacy 'Carol Davila' Bucharest Romania
Clinical Epidemiology Division Department of Medicine Solna Karolinska Institutet Stockholm Sweden
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Rheumatology Aarhus University Hospital Aarhus Denmark
Department of Rheumatology Diakonhjemmet Hospital Oslo Norway
Department of Rheumatology Geneva University Hospital Geneva Switzerland
Department of Rheumatology University Hospital Zurich Zurich Switzerland
Division of Rheumatology Department of Medicine Hospital of Southern Norway Trust Kristiansand
GISEA Registry Rheumatology Unit DETO University of Bari Italy
Inflammation Center Department of Rheumatology Helsinki University Hospital Helsinki Finland
Rheumatology Service Hospital Clinico Universitario Santiago de Compostela Spain
ROB FIN Registry Helsinki University and Helsinki University Hospital Helsinki Finland
TURKBIO Registry and Division of Rheumatology School of Medicine Firat University Elazig Turkey
TURKBIO Registry and Division of Rheumatology School of Medicine Kocaeli University Izmit Turkey
University of Iceland Faculty of Medicine Landspitali University Hospital Reykjavik Iceland
Citace poskytuje Crossref.org
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- $a Michelsen, Brigitte $u EuroSpA Coordinating Center, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark ; Division of Rheumatology, Department of Medicine, Hospital of Southern Norway Trust, Kristiansand ; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
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