Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival

N. Attaran, X. Gu, PJ. Coates, R. Fåhraeus, L. Boldrup, T. Wilms, L. Wang, N. Sgaramella, K. Zborayova, K. Nylander

. 2020 ; 21 (17) : . [pub] 20200827

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012240

Grantová podpora
180542 Cancerfonden
2019 Umea University
2019 Lion's cancer research foundation
2019 Region Västerbotten
MMCI, 00209805 Ministry of health Czech Republic

Oral cancers are surrounded by epithelium that histologically might seem normal, but genetically has aberrations. In patients with squamous cell carcinoma of the oral tongue (SCCOT), it is therefore important to study not only the tumor but also the clinically tumor-free contralateral tongue tissue that remains in the patient after treatment to map changes of prognostic and/or diagnostic value. The transporter associated with antigen processing (TAP) dimer is a key factor in the process of activating cytotoxic T cells. By downregulating the expression of TAP, tumor cells can escape cytotoxic T cell recognition. Biopsies from tumor and clinically tumor-free contralateral tongue tissue in 21 patients with SCCOT were analyzed together with tongue biopsies from 14 healthy individuals, which served as the control group. Dividing patients into TAP1-high and TAP1-low groups according to the median TAP1 level in tumor-free samples showed that patients with lower TAP1 mRNA levels in tumor-free samples had better overall (p = 0.003) and disease-free survival (p = 0.002). The results showing that TAP1 levels in tumor-free tongue tissue contralateral to the SCCOT correlate with survival is an important contribution to early diagnosis and follow up of SCCOT.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21012240
003      
CZ-PrNML
005      
20210507102659.0
007      
ta
008      
210420s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms21176220 $2 doi
035    __
$a (PubMed)32867395
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Attaran, Nima $u Department of Clinical Sciences/ENT, Umeå University, SE-901 85 Umeå, Sweden
245    10
$a Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival / $c N. Attaran, X. Gu, PJ. Coates, R. Fåhraeus, L. Boldrup, T. Wilms, L. Wang, N. Sgaramella, K. Zborayova, K. Nylander
520    9_
$a Oral cancers are surrounded by epithelium that histologically might seem normal, but genetically has aberrations. In patients with squamous cell carcinoma of the oral tongue (SCCOT), it is therefore important to study not only the tumor but also the clinically tumor-free contralateral tongue tissue that remains in the patient after treatment to map changes of prognostic and/or diagnostic value. The transporter associated with antigen processing (TAP) dimer is a key factor in the process of activating cytotoxic T cells. By downregulating the expression of TAP, tumor cells can escape cytotoxic T cell recognition. Biopsies from tumor and clinically tumor-free contralateral tongue tissue in 21 patients with SCCOT were analyzed together with tongue biopsies from 14 healthy individuals, which served as the control group. Dividing patients into TAP1-high and TAP1-low groups according to the median TAP1 level in tumor-free samples showed that patients with lower TAP1 mRNA levels in tumor-free samples had better overall (p = 0.003) and disease-free survival (p = 0.002). The results showing that TAP1 levels in tumor-free tongue tissue contralateral to the SCCOT correlate with survival is an important contribution to early diagnosis and follow up of SCCOT.
650    _2
$a peptidový transportér TAP1 $x genetika $7 D000071181
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a nádorové biomarkery $x genetika $7 D014408
650    _2
$a biopsie $7 D001706
650    _2
$a spinocelulární karcinom $x genetika $x mortalita $x patologie $7 D002294
650    _2
$a studie případů a kontrol $7 D016022
650    12
$a down regulace $7 D015536
650    _2
$a časná detekce nádoru $7 D055088
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a regulace genové exprese u nádorů $7 D015972
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prognóza $7 D011379
650    _2
$a analýza přežití $7 D016019
650    _2
$a jazyk $x chemie $x patologie $7 D014059
650    _2
$a nádory jazyka $x genetika $x mortalita $x patologie $7 D014062
655    _2
$a časopisecké články $7 D016428
700    1_
$a Gu, Xiaolian $u Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden
700    1_
$a Coates, Philip J $u RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic
700    1_
$a Fåhraeus, Robin $u Institut de Génétique Moléculaire, Université Paris 7, Inserm UMR 1162, 750 13 Paris, France
700    1_
$a Boldrup, Linda $u Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden
700    1_
$a Wilms, Torben $u Department of Clinical Sciences/ENT, Umeå University, SE-901 85 Umeå, Sweden
700    1_
$a Wang, Lixiao $u Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden
700    1_
$a Sgaramella, Nicola $u Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden
700    1_
$a Zborayova, Katarina $u Department of Clinical Sciences/ENT, Umeå University, SE-901 85 Umeå, Sweden
700    1_
$a Nylander, Karin $u Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 21, č. 17 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32867395 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210507102658 $b ABA008
999    __
$a ok $b bmc $g 1650583 $s 1132619
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 21 $c 17 $e 20200827 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a 180542 $p Cancerfonden
GRA    __
$a 2019 $p Umea University
GRA    __
$a 2019 $p Lion's cancer research foundation
GRA    __
$a 2019 $p Region Västerbotten
GRA    __
$a MMCI, 00209805 $p Ministry of health Czech Republic
LZP    __
$a Pubmed-20210420

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace