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Experimental Evaluation of the Impact of Gadolinium Orthovanadate GdVO4:Eu3+ Nanoparticles on the Carrageenan-Induced Intestinal Inflammation
A. S. Tkachenko, G. I. Gubina-Vakulyck, V. K. Klochkov, N. S. Kavok, A. I. Onishchenko, T. V. Gorbach, O. A. Nakonechna
Language English Country Czech Republic
Document type Journal Article
Digital library NLK
Source
NLK
Directory of Open Access Journals
from 1997
Free Medical Journals
from 1997
Open Access Digital Library
from 1997-01-01
Medline Complete (EBSCOhost)
from 2012-06-01
ROAD: Directory of Open Access Scholarly Resources
from 1997
- MeSH
- C-Reactive Protein drug effects metabolism MeSH
- Enterocolitis blood chemically induced pathology MeSH
- Gadolinium pharmacology MeSH
- Inflammatory Bowel Diseases blood pathology MeSH
- Interleukin-10 blood MeSH
- Interleukin-1beta blood drug effects MeSH
- Carrageenan toxicity MeSH
- Metal Nanoparticles * MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Orosomucoid drug effects metabolism MeSH
- HSP90 Heat-Shock Proteins drug effects metabolism MeSH
- Free Radical Scavengers pharmacology MeSH
- Intestinal Mucosa drug effects metabolism pathology MeSH
- Tumor Necrosis Factor-alpha blood drug effects MeSH
- Vanadates pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
AIM: To evaluate the effects of orally administered gadolinium orthovanadate GdVO4:Eu3+ nanoparticles (VNPs) on the course of chronic carrageenan-induced intestinal inflammation. METHODS: Samples of small intestinal tissue were collected from four groups of rats (intact, after administration of VNPs, with carrageenaninduced intestinal inflammation, with carrageenan-induced intestinal inflammation orally exposed to VNPs) to assess the intestinal morphology and HSP90α expression. Levels of seromucoid, C-reactive protein, TNF-α, IL-1β and IL-10 were determined in blood serum. RESULTS: Oral exposure to VNPs was associated with neither elevation of inflammation markers in blood serum nor HSP90α overexpression in the small intestine, i.e. no toxic effects of VNPs were observed. Carrageenan-induced intestinal inflammation was accompanied by higher levels of TNF-α and IL-1β, as well as HSP90α upregulation in the intestinal mucosa, compared with controls. Administration of VNPs to rats with enteritis did not lead to statistically significant changes in concentrations of circulating pro-inflammatory cytokines with the trend towards their increase. CONCLUSION: No adverse effects were observed in rats orally exposed to VNPs at a dose of 20 μg/kg during two weeks. Using the experimental model of carrageenan-induced enteritis, it was demonstrated that VNPs at the dose used in our study did not affect the course of intestinal inflammation.
Department of Biochemistry Kharkiv National Medical University Kharkiv Ukraine
Department of Pathological Anatomy Kharkiv National Medical University Kharkiv Ukraine
Institute for Scintillation Materials National Academy of Sciences of Ukraine Kharkiv Ukraine
References provided by Crossref.org
Literatura
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- $a AIM: To evaluate the effects of orally administered gadolinium orthovanadate GdVO4:Eu3+ nanoparticles (VNPs) on the course of chronic carrageenan-induced intestinal inflammation. METHODS: Samples of small intestinal tissue were collected from four groups of rats (intact, after administration of VNPs, with carrageenaninduced intestinal inflammation, with carrageenan-induced intestinal inflammation orally exposed to VNPs) to assess the intestinal morphology and HSP90α expression. Levels of seromucoid, C-reactive protein, TNF-α, IL-1β and IL-10 were determined in blood serum. RESULTS: Oral exposure to VNPs was associated with neither elevation of inflammation markers in blood serum nor HSP90α overexpression in the small intestine, i.e. no toxic effects of VNPs were observed. Carrageenan-induced intestinal inflammation was accompanied by higher levels of TNF-α and IL-1β, as well as HSP90α upregulation in the intestinal mucosa, compared with controls. Administration of VNPs to rats with enteritis did not lead to statistically significant changes in concentrations of circulating pro-inflammatory cytokines with the trend towards their increase. CONCLUSION: No adverse effects were observed in rats orally exposed to VNPs at a dose of 20 μg/kg during two weeks. Using the experimental model of carrageenan-induced enteritis, it was demonstrated that VNPs at the dose used in our study did not affect the course of intestinal inflammation.
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