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Experimental Evaluation of the Impact of Gadolinium Orthovanadate GdVO4:Eu3+ Nanoparticles on the Carrageenan-Induced Intestinal Inflammation
A. S. Tkachenko, G. I. Gubina-Vakulyck, V. K. Klochkov, N. S. Kavok, A. I. Onishchenko, T. V. Gorbach, O. A. Nakonechna
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Digitální knihovna NLK
Zdroj
NLK
Directory of Open Access Journals
od 1997
Free Medical Journals
od 1997
Open Access Digital Library
od 1997-01-01
Medline Complete (EBSCOhost)
od 2012-06-01
ROAD: Directory of Open Access Scholarly Resources
od 1997
- MeSH
- C-reaktivní protein účinky léků metabolismus MeSH
- enterokolitida krev chemicky indukované patologie MeSH
- gadolinium farmakologie MeSH
- idiopatické střevní záněty krev patologie MeSH
- interleukin-10 krev MeSH
- interleukin-1beta krev účinky léků MeSH
- karagenan toxicita MeSH
- kovové nanočástice * MeSH
- krysa rodu rattus MeSH
- modely nemocí na zvířatech MeSH
- orosomukoid účinky léků metabolismus MeSH
- proteiny tepelného šoku HSP90 účinky léků metabolismus MeSH
- scavengery volných radikálů farmakologie MeSH
- střevní sliznice účinky léků metabolismus patologie MeSH
- TNF-alfa krev účinky léků MeSH
- vanadáty farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
AIM: To evaluate the effects of orally administered gadolinium orthovanadate GdVO4:Eu3+ nanoparticles (VNPs) on the course of chronic carrageenan-induced intestinal inflammation. METHODS: Samples of small intestinal tissue were collected from four groups of rats (intact, after administration of VNPs, with carrageenaninduced intestinal inflammation, with carrageenan-induced intestinal inflammation orally exposed to VNPs) to assess the intestinal morphology and HSP90α expression. Levels of seromucoid, C-reactive protein, TNF-α, IL-1β and IL-10 were determined in blood serum. RESULTS: Oral exposure to VNPs was associated with neither elevation of inflammation markers in blood serum nor HSP90α overexpression in the small intestine, i.e. no toxic effects of VNPs were observed. Carrageenan-induced intestinal inflammation was accompanied by higher levels of TNF-α and IL-1β, as well as HSP90α upregulation in the intestinal mucosa, compared with controls. Administration of VNPs to rats with enteritis did not lead to statistically significant changes in concentrations of circulating pro-inflammatory cytokines with the trend towards their increase. CONCLUSION: No adverse effects were observed in rats orally exposed to VNPs at a dose of 20 μg/kg during two weeks. Using the experimental model of carrageenan-induced enteritis, it was demonstrated that VNPs at the dose used in our study did not affect the course of intestinal inflammation.
Department of Biochemistry Kharkiv National Medical University Kharkiv Ukraine
Department of Pathological Anatomy Kharkiv National Medical University Kharkiv Ukraine
Institute for Scintillation Materials National Academy of Sciences of Ukraine Kharkiv Ukraine
Citace poskytuje Crossref.org
Literatura
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