F-Box a WD repetice obsahující protein 7 [F-Box-WD Repeat-Containing Protein 7]

tematický
3
Termíny

protein FBXW7

 

F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein

Perzistentní odkaz   https://www.medvik.cz/link/D000073979
Definice

Složka ubikvitinligázy SCF(Fbw7), která obsahuje motiv F-boxu a několik WD repetic. Rozpoznává a váže fosforylované signály v několika proteinech zapojených do buněčné proliferace a navádí je do komplexu SCF k ubikvitinaci. Mezi cíle patří cyklin E, protoonkogenní proteiny c-jun, protoonkogenní proteiny c-myc a mitogenem aktivované proteinkinázy JNK.

A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

DUI
D000073979 MeSH Prohlížeč
CUI
M000625118
Předchozí užití
Cell Cycle Proteins (2006-2017); F-Box Proteins (2006-2017); Ubiquitin-Protein Ligases (2006-2017)
Historická pozn.
2018
Veřejná pozn.
2018

D Chemikálie a léčiva
D08.811 enzymy 1 547
D08.811.464 ligasy 33
D08.811.464.938 komplexy ubikvitinligas 25
D08.811.464.938.750 ubikvitinligasy 80
D08.811.464.938.750.750 proteinligasy komplexu SCF 14
D08.811.464.938.750.750.500 kulinové proteiny 7
D08.811.464.938.750.750.750 F-Box a WD repetice obsahující protein 7 3
D12.776 proteiny 2 575
D12.776.157 transportní proteiny 546
D12.776.157.169 F-box proteiny 14
D12.776.167.049 kinasy Aurora 4
D12.776.167.100 fosfatasy cdc25 28
D12.776.167.163 koheziny
D12.776.167.175 kulinové proteiny 7
D12.776.167.200 cyklin-dependentní kinasy 228
D12.776.167.218 cykliny 112
D12.776.167.254 proteiny GADD45
D12.776.167.265 geminin 1
D12.776.167.313 Mad2 protein 1
D12.776.167.409 MCM proteiny 4
D12.776.167.457 kinasy NEK 4
D12.776.167.469 polo-like kinasy
D12.776.167.481 protein S100A6 2
D12.776.167.504 sekurin 1
D12.776.167.552 separasa 1
D12.776.167.564 protein SMC1
D12.776.167.576 survivin 6