F-Box-WD Repeat-Containing Protein 7 [F-Box a WD repetice obsahující protein 7]
topical
3
- Terms
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protein FBXW7
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F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein
Persistent link
https://www.medvik.cz/link/D000073979
Definition
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
- DUI
- D000073979 MeSH Browser
- CUI
- M000625118
- Previous indexing
- Cell Cycle Proteins (2006-2017); F-Box Proteins (2006-2017); Ubiquitin-Protein Ligases (2006-2017)
- History note
- 2018
- Public note
- 2018
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AG
- agonists 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 0
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 1
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 1
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D12.776.157.169.500
beta-Transducin Repeat-Containing Proteins
D12.776.167.163
Cohesins
D12.776.167.254
GADD45 Proteins
D12.776.167.469
Polo-like Kinases
D12.776.167.564
Structural Maintenance of Chromosome Protein 1