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Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential
L. Nahar, S. Al-Majmaie, A. Al-Groshi, A. Rasul, SD. Sarker
Language English Country Switzerland
Document type Journal Article, Review
Grant support
No. CZ.02.1.01/0.0/0.0/16_019/0000868
the European Regional Development Fund
NLK
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- MeSH
- Clausena chemistry MeSH
- Furocoumarins biosynthesis pharmacology MeSH
- Coumarins chemistry MeSH
- Plants, Medicinal chemistry MeSH
- Humans MeSH
- Plant Extracts metabolism pharmacology MeSH
- Ruta chemistry MeSH
- Rutaceae chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.
References provided by Crossref.org
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