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Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro
P. Šalamúnová, L. Cupalová, M. Majerská, J. Treml, G. Ruphuy, K. Šmejkal, F. Štěpánek, J. Hanuš, J. Hošek
International journal of biological macromolecules.
2021 ;
169 (-) :
443-451.
[pub] 20201216
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc21019331
- MeSH
- antiflogistika farmakologie MeSH
- antioxidancia farmakologie MeSH
- artemisininy farmakologie MeSH
- cytokiny MeSH
- flavonoidy chemie farmakologie MeSH
- glukany chemie farmakologie MeSH
- katechin analogy a deriváty chemie farmakologie MeSH
- kyselina ellagová chemie farmakologie MeSH
- monocyty účinky léků MeSH
- NF-kappa B MeSH
- resveratrol chemie farmakologie MeSH
- Saccharomyces cerevisiae - proteiny MeSH
- Saccharomyces cerevisiae MeSH
- Publikační typ
- časopisecké články MeSH
Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
Citace poskytuje Crossref.org
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- $a Šalamúnová, Petra $u Department of Chemical Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic. Electronic address: petra.salamunova@vscht.cz
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- $a Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
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- $a Cupalová, Lucie $u Division of Biologically Active Complexes and Molecular Magnets, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic; Department of Molecular Pharmacy, Masaryk University, Palackého tř. 1946/1, 612 00 Brno, Czech Republic
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