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The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic

J. Tkadlec, V. Capek, M. Brajerova, E. Smelikova, O. Melter, T. Bergerova, S. Polivkova, M. Balejova, M. Hanslianova, D. Fackova, K. Neradova, R. Tejkalova, I. Vagnerova, N. Bartonikova, E. Chmelarova, P. Drevinek, M. Krutova

. 2021 ; 76 (1) : 55-64. [pub] 20210101

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019555

Grantová podpora
NV17-30460A MZ0 CEP - Centrální evidence projektů

OBJECTIVES: To gain data on the current molecular epidemiology and resistance of MRSA in the Czech Republic. METHODS: Between September 2017 and January 2018, a total of 441 single-patient MRSA isolates were collected from 11 Czech hospitals and analysed by spa typing, SCCmec typing, antibiotic susceptibility testing, detection of the PVL toxin and the arcA gene. RESULTS: Of all MRSA isolates, 81.41% (n = 359) belonged to the CC5-MRSA clone represented by the spa types t003 (n = 136), t586 (n = 92), t014 (n = 81), t002 (n = 20) and other spa types (n = 30); a majority of the CC5 isolates (n = 348, 96.94%) carried SCCmec type II. The occurrence of CC5-MRSA was more likely in older inpatients and associated with a healthcare origin (P < 0.001). The CC5-MRSA isolates were resistant to more antimicrobial drugs compared with the other MRSAs (P < 0.001). Interestingly, t586 was detected in blood samples more often than the other spa types and, contrary to other spa types belonging to CC5-MRSA, t586 was not associated with patients of advanced age. Other frequently found lineages were CC8 (n = 17), CC398 (n = 11) and CC59 (n = 10). The presence of the PVL was detected in 8.62% (n = 38) of the MRSA isolates. CONCLUSIONS: The healthcare-associated CC5-MRSA-II lineage (t003, t586, t014) was found to be predominant in the Czech Republic. t586 is a newly emerging spa type in the Czech Republic, yet reported rarely in other countries. Our observations stress the need for MRSA surveillance in the Czech Republic in order to monitor changes in MRSA epidemiology.

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$a The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic / $c J. Tkadlec, V. Capek, M. Brajerova, E. Smelikova, O. Melter, T. Bergerova, S. Polivkova, M. Balejova, M. Hanslianova, D. Fackova, K. Neradova, R. Tejkalova, I. Vagnerova, N. Bartonikova, E. Chmelarova, P. Drevinek, M. Krutova
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$a OBJECTIVES: To gain data on the current molecular epidemiology and resistance of MRSA in the Czech Republic. METHODS: Between September 2017 and January 2018, a total of 441 single-patient MRSA isolates were collected from 11 Czech hospitals and analysed by spa typing, SCCmec typing, antibiotic susceptibility testing, detection of the PVL toxin and the arcA gene. RESULTS: Of all MRSA isolates, 81.41% (n = 359) belonged to the CC5-MRSA clone represented by the spa types t003 (n = 136), t586 (n = 92), t014 (n = 81), t002 (n = 20) and other spa types (n = 30); a majority of the CC5 isolates (n = 348, 96.94%) carried SCCmec type II. The occurrence of CC5-MRSA was more likely in older inpatients and associated with a healthcare origin (P < 0.001). The CC5-MRSA isolates were resistant to more antimicrobial drugs compared with the other MRSAs (P < 0.001). Interestingly, t586 was detected in blood samples more often than the other spa types and, contrary to other spa types belonging to CC5-MRSA, t586 was not associated with patients of advanced age. Other frequently found lineages were CC8 (n = 17), CC398 (n = 11) and CC59 (n = 10). The presence of the PVL was detected in 8.62% (n = 38) of the MRSA isolates. CONCLUSIONS: The healthcare-associated CC5-MRSA-II lineage (t003, t586, t014) was found to be predominant in the Czech Republic. t586 is a newly emerging spa type in the Czech Republic, yet reported rarely in other countries. Our observations stress the need for MRSA surveillance in the Czech Republic in order to monitor changes in MRSA epidemiology.
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$a Capek, Vaclav $u Bioinformatics Centre, Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
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$a Brajerova, Marie $u Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
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$a Smelikova, Eva $u Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
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$a Melter, Oto $u Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
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$a Bergerova, Tamara $u Department of Microbiology, Faculty of Medicine and University Hospital Plzen, Charles University in Prague, Plzen, Czech Republic
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$a Polivkova, Sylvia $u Department of Infectious Diseases, Charles University, 3rd Faculty of Medicine and Bulovka Teaching Hospital, Prague, Czech Republic
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$a Balejova, Magda $u Department of Medical Microbiology, Hospital Ceske Budejovice, Czech Republic
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$a Hanslianova, Marketa $u Department of Medical Microbiology, University Hospital Brno, Czech Republic
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$a Fackova, Daniela $u Department of Medical Microbiology and Immunology, Hospital Liberec, Czech Republic
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$a Neradova, Katerina $u Department of Clinical Microbiology, University Hospital Hradec Kralove, Czech Republic
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$a Tejkalova, Renata $u Department of Medical Microbiology, Faculty of Medicine, Masaryk University and St Anne's University Hospital, Brno, Czech Republic
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$a Vagnerova, Iva $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Czech Republic
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$a Bartonikova, Natasa $u Department of Medical Microbiology, Tomas Bata's Hospital Zlin, Czech Republic
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$a Chmelarova, Eva $u Department of Microbiology, Agel Laboratories a.s., Ostrava-Vitkovice, Czech Republic
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$a Drevinek, Pavel $u Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
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$a Krutova, Marcela $u Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
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