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Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma
H. Breiteneder, YQ. Peng, I. Agache, Z. Diamant, T. Eiwegger, WJ. Fokkens, C. Traidl-Hoffmann, K. Nadeau, RE. O'Hehir, L. O'Mahony, O. Pfaar, MJ. Torres, DY. Wang, L. Zhang, CA. Akdis
Language English Country Denmark
Document type Journal Article, Review
PubMed
32893900
DOI
10.1111/all.14582
Knihovny.cz E-resources
- MeSH
- Rhinitis, Allergic * diagnosis therapy MeSH
- Hypersensitivity * diagnosis therapy MeSH
- Dermatitis, Atopic * MeSH
- Biomarkers MeSH
- Asthma * diagnosis therapy MeSH
- Humans MeSH
- Food Hypersensitivity * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.
Allergy Asthma and Clinical Immunology Service Alfred Health Melbourne Vic Australia
Allergy Unit Regional University Hospital of Malaga IBIMA UMA ARADyAL Malaga Spain
CK CARE Christine Kühne Center for Allergy Research and Education Davos Switzerland
Department of Immunology University of Toronto Toronto ON Canada
Department of Otorhinolaryngology Amsterdam University Medical Centres Amsterdam The Netherlands
Institute of Pathophysiology and Allergy Research Medical University of Vienna Vienna Austria
Otorhinolaryngology Hospital The 1st Affiliated Hospital Sun Yat Sen University Guangzhou China
Sean N Parker Center for Allergy and Asthma Research Stanford University Stanford CA USA
Swiss Institute of Allergy and Asthma Research University Zurich Davos Switzerland
Translational Medicine Program Research Institute Hospital for Sick Children Toronto ON Canada
ZIEL Institute for Food and Health Technical University of Munich Freising Weihenstephan Germany
References provided by Crossref.org
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