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Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al

M. Murtinger, B. Wirleitner, L. Hradecký, G. Comploj, J. Okhowat, D. Spitzer, J. Stadler, R. Haidbauer, M. Schuff, S. Yildirim, T. Soepenberg, K. Eibner, F. Gagsteiger

. 2020 ; 37 (11) : 2691-2698. [pub] 20201006

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019901

Grantová podpora
No award Not applicable
No award No funding

E-zdroje Online Plný text

NLK Free Medical Journals od 2008 do Před 1 rokem
PubMed Central od 1997 do Před 1 rokem
Europe PubMed Central od 1997 do Před 1 rokem
ProQuest Central od 1999-01-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1999-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 1999-01-01 do Před 1 rokem

Odkazy

PubMed 33025400
DOI 10.1007/s10815-020-01954-9
Knihovny.cz E-zdroje

A recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage (uterine flushing) and subjected to genetic testing for aneuploidies (PGT-A). Oocyte donors with persistently elevated hCG levels, indicating the implantation of one or more embryos after uterine lavage, had to undergo uterine curettage and/or treatment with methotrexate. A critical opinion paper discussing the aforementioned study was published by De Santis and colleagues and has raised critical issues that are largely technical in nature. However, this opinion paper neglects-from our point of view-critical issues of the Mexican study regarding ethical principles and moral standards in human research. These aspects are summarized below.

Citace poskytuje Crossref.org

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