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Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al
M. Murtinger, B. Wirleitner, L. Hradecký, G. Comploj, J. Okhowat, D. Spitzer, J. Stadler, R. Haidbauer, M. Schuff, S. Yildirim, T. Soepenberg, K. Eibner, F. Gagsteiger
Language English Country Netherlands
Document type Journal Article
Grant support
No award
Not applicable
No award
No funding
NLK
Free Medical Journals
from 2008 to 1 year ago
PubMed Central
from 1997 to 1 year ago
Europe PubMed Central
from 1997 to 1 year ago
ProQuest Central
from 1999-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2011-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1999-01-01 to 1 year ago
Public Health Database (ProQuest)
from 1999-01-01 to 1 year ago
- MeSH
- Aneuploidy MeSH
- Biomedical Research ethics MeSH
- Adult MeSH
- Fertilization in Vitro ethics MeSH
- Embryo Implantation genetics MeSH
- Humans MeSH
- Oocyte Retrieval ethics MeSH
- Oocytes cytology growth & development MeSH
- Preimplantation Diagnosis ethics MeSH
- Embryo Transfer ethics MeSH
- Reproductive Medicine ethics MeSH
- Semen cytology MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
A recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage (uterine flushing) and subjected to genetic testing for aneuploidies (PGT-A). Oocyte donors with persistently elevated hCG levels, indicating the implantation of one or more embryos after uterine lavage, had to undergo uterine curettage and/or treatment with methotrexate. A critical opinion paper discussing the aforementioned study was published by De Santis and colleagues and has raised critical issues that are largely technical in nature. However, this opinion paper neglects-from our point of view-critical issues of the Mexican study regarding ethical principles and moral standards in human research. These aspects are summarized below.
EuBios Centri Fivet Prof Zech Merano Italy
IVF Zentren Prof Zech Pilsen Pilsen Czech Republic
IVF Zentren Prof Zech Salzburg Salzburg Austria
Medical Department Kinderwunsch MVZ Ulm Ulm Germany
MVZ Kinderwunsch Münsterland Bocholt Germany
References provided by Crossref.org
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- $a A recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage (uterine flushing) and subjected to genetic testing for aneuploidies (PGT-A). Oocyte donors with persistently elevated hCG levels, indicating the implantation of one or more embryos after uterine lavage, had to undergo uterine curettage and/or treatment with methotrexate. A critical opinion paper discussing the aforementioned study was published by De Santis and colleagues and has raised critical issues that are largely technical in nature. However, this opinion paper neglects-from our point of view-critical issues of the Mexican study regarding ethical principles and moral standards in human research. These aspects are summarized below.
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