Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

L. Nahar, AD. Talukdar, D. Nath, S. Nath, A. Mehan, FMD. Ismail, SD. Sarker

. 2020 ; 25 (21) : . [pub] 20201028

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc21019948

Grant support
Project ENOCH (No. CZ.02.1.01/0.0/0.0/16_019/0000868) The European Regional Development Fund - Project ENOCH

Calanolides are tetracyclic 4-substituted dipyranocoumarins. Calanolide A, isolated from the leaves and twigs of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens, is the first member of this group of compounds with anti-HIV-1 activity mediated by reverse transcriptase inhibition. Calanolides are classified pharmacologically as non-nucleoside reverse transcriptase inhibitors (NNRTI). There are at least 15 naturally occurring calanolides distributed mainly within the genus Calophyllum, but some of them are also present in the genus Clausena. Besides significant anti-HIV properties, which have been exploited towards potential development of new NNRTIs for anti-HIV therapy, calanolides have also been found to possess anticancer, antimicrobial and antiparasitic potential. This review article provides a comprehensive update on all aspects of naturally occurring calanolides, including their chemistry, natural occurrence, biosynthesis, pharmacological and toxicological aspects including mechanism of action and structure activity relationships, pharmacokinetics, therapeutic potentials and available patents.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019948
003      
CZ-PrNML
005      
20210830101543.0
007      
ta
008      
210728s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/molecules25214983 $2 doi
035    __
$a (PubMed)33126458
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Nahar, Lutfun $u Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech Republic
245    10
$a Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential / $c L. Nahar, AD. Talukdar, D. Nath, S. Nath, A. Mehan, FMD. Ismail, SD. Sarker
520    9_
$a Calanolides are tetracyclic 4-substituted dipyranocoumarins. Calanolide A, isolated from the leaves and twigs of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens, is the first member of this group of compounds with anti-HIV-1 activity mediated by reverse transcriptase inhibition. Calanolides are classified pharmacologically as non-nucleoside reverse transcriptase inhibitors (NNRTI). There are at least 15 naturally occurring calanolides distributed mainly within the genus Calophyllum, but some of them are also present in the genus Clausena. Besides significant anti-HIV properties, which have been exploited towards potential development of new NNRTIs for anti-HIV therapy, calanolides have also been found to possess anticancer, antimicrobial and antiparasitic potential. This review article provides a comprehensive update on all aspects of naturally occurring calanolides, including their chemistry, natural occurrence, biosynthesis, pharmacological and toxicological aspects including mechanism of action and structure activity relationships, pharmacokinetics, therapeutic potentials and available patents.
650    _2
$a biologické přípravky $x chemie $x metabolismus $x farmakologie $x terapeutické užití $7 D001688
650    _2
$a lidé $7 D006801
650    _2
$a pyranokumariny $x chemie $x metabolismus $x farmakologie $x terapeutické užití $7 D039681
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Talukdar, Anupam Das $u Department of Life Science and Bioinformatics, Assam University, Silchar, Assam 788011, India
700    1_
$a Nath, Deepa $u Department of Botany, Gurucharan College, Silchar, Assam 788004, India
700    1_
$a Nath, Sushmita $u Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK
700    1_
$a Mehan, Aman $u School of Clinical Medicine, University of Cambridge, Cambridge CB2 OSP, UK
700    1_
$a Ismail, Fyaz M D $u Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK
700    1_
$a Sarker, Satyajit D $u Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK
773    0_
$w MED00180394 $t Molecules (Basel, Switzerland) $x 1420-3049 $g Roč. 25, č. 21 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33126458 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830101543 $b ABA008
999    __
$a ok $b bmc $g 1690697 $s 1140394
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 25 $c 21 $e 20201028 $i 1420-3049 $m Molecules $n Molecules $x MED00180394
GRA    __
$a Project ENOCH (No. CZ.02.1.01/0.0/0.0/16_019/0000868) $p The European Regional Development Fund - Project ENOCH
LZP    __
$a Pubmed-20210728
Back

Find record

Citation metrics

Archiving options