Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Impact of sex and depressed mood on the central regulation of cardiac autonomic function

RG. Garcia, K. Mareckova, LM. Holsen, JE. Cohen, S. Whitfield-Gabrieli, V. Napadow, R. Barbieri, JM. Goldstein

. 2020 ; 45 (8) : 1280-1288. [pub] 20200309

Language English Country Great Britain

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21020412

Grant support
R03 MH105585 NIMH NIH HHS - United States
P50 MH082679 NIMH NIH HHS - United States
OT2 OD023867 NIH HHS - United States
UL1 RR025758 NCRR NIH HHS - United States
R21 MH103468 NIMH NIH HHS - United States

Cardiac autonomic dysregulation has been implicated in the comorbidity of major psychiatric disorders and cardiovascular disease, potentially through dysregulation of physiological responses to negative stressful stimuli (here, shortened to stress response). Further, sex differences in these comorbidities are substantial. Here, we tested the hypothesis that mood- and sex-dependent alterations in brain circuitry implicated in the regulation of the stress response are associated with reduced peripheral parasympathetic activity during negative emotional arousal. Fifty subjects (28 females) including healthy controls and individuals with major depression, bipolar psychosis and schizophrenia were evaluated. Functional magnetic resonance imaging and physiology (cardiac pulse) data were acquired during a mild visual stress reactivity challenge. Associations between changes in activity and functional connectivity of the stress response circuitry and variations in cardiovagal activity [normalized high frequency power of heart rate variability (HFn)] were evaluated using GLM analyses, including interactions with depressed mood and sex across disorders. Our results revealed that in women with high depressed mood, lower cardiovagal activity in response to negative affective stimuli was associated with greater activation of hypothalamus and right amygdala and reduced connectivity between hypothalamus and right orbitofrontal cortex, amygdala, and hippocampus. No significant associations were observed in women with low levels of depressed mood or men. Our results revealed mood- and sex-dependent interactions in the central regulation of cardiac autonomic activity in response to negative affective stimuli. These findings provide a potential pathophysiological mechanism for previously observed sex differences in the comorbidity of major depression and cardiovascular disease.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21020412
003      
CZ-PrNML
005      
20210830102117.0
007      
ta
008      
210728s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41386-020-0651-x $2 doi
035    __
$a (PubMed)32152473
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Garcia, Ronald G $u Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA $u Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
245    10
$a Impact of sex and depressed mood on the central regulation of cardiac autonomic function / $c RG. Garcia, K. Mareckova, LM. Holsen, JE. Cohen, S. Whitfield-Gabrieli, V. Napadow, R. Barbieri, JM. Goldstein
520    9_
$a Cardiac autonomic dysregulation has been implicated in the comorbidity of major psychiatric disorders and cardiovascular disease, potentially through dysregulation of physiological responses to negative stressful stimuli (here, shortened to stress response). Further, sex differences in these comorbidities are substantial. Here, we tested the hypothesis that mood- and sex-dependent alterations in brain circuitry implicated in the regulation of the stress response are associated with reduced peripheral parasympathetic activity during negative emotional arousal. Fifty subjects (28 females) including healthy controls and individuals with major depression, bipolar psychosis and schizophrenia were evaluated. Functional magnetic resonance imaging and physiology (cardiac pulse) data were acquired during a mild visual stress reactivity challenge. Associations between changes in activity and functional connectivity of the stress response circuitry and variations in cardiovagal activity [normalized high frequency power of heart rate variability (HFn)] were evaluated using GLM analyses, including interactions with depressed mood and sex across disorders. Our results revealed that in women with high depressed mood, lower cardiovagal activity in response to negative affective stimuli was associated with greater activation of hypothalamus and right amygdala and reduced connectivity between hypothalamus and right orbitofrontal cortex, amygdala, and hippocampus. No significant associations were observed in women with low levels of depressed mood or men. Our results revealed mood- and sex-dependent interactions in the central regulation of cardiac autonomic activity in response to negative affective stimuli. These findings provide a potential pathophysiological mechanism for previously observed sex differences in the comorbidity of major depression and cardiovascular disease.
650    _2
$a amygdala $7 D000679
650    _2
$a mozek $x diagnostické zobrazování $7 D001921
650    12
$a depresivní porucha unipolární $7 D003865
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a hipokampus $7 D006624
650    _2
$a lidé $7 D006801
650    12
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a mužské pohlaví $7 D008297
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Mareckova, Klara $u Brain and Mind Research Programme, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Holsen, Laura M $u Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
700    1_
$a Cohen, Justine E $u Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
700    1_
$a Whitfield-Gabrieli, Susan $u Department of Psychology, Northeastern University, Boston, MA, USA
700    1_
$a Napadow, Vitaly $u Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
700    1_
$a Barbieri, Riccardo $u Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy $u Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
700    1_
$a Goldstein, Jill M $u Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. jill_goldstein@hms.harvard.edu $u Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. jill_goldstein@hms.harvard.edu $u Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jill_goldstein@hms.harvard.edu $u Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA. jill_goldstein@hms.harvard.edu
773    0_
$w MED00006658 $t Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology $x 1740-634X $g Roč. 45, č. 8 (2020), s. 1280-1288
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32152473 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830102118 $b ABA008
999    __
$a ok $b bmc $g 1691062 $s 1140858
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 45 $c 8 $d 1280-1288 $e 20200309 $i 1740-634X $m Neuropsychopharmacology $n Neuropsychopharmacology $x MED00006658
GRA    __
$a R03 MH105585 $p NIMH NIH HHS $2 United States
GRA    __
$a P50 MH082679 $p NIMH NIH HHS $2 United States
GRA    __
$a OT2 OD023867 $p NIH HHS $2 United States
GRA    __
$a UL1 RR025758 $p NCRR NIH HHS $2 United States
GRA    __
$a R21 MH103468 $p NIMH NIH HHS $2 United States
LZP    __
$a Pubmed-20210728

Find record

Citation metrics

Archiving options