Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Memory outcomes of temporal lobe surgery in adults aged over 45 years

I. Tyrlíková, Z. Hummelová, S. Goldemundová, E. Koriťáková, T. Nečasová, M. Tyrlík, M. Brázdil, J. Chrastina, J. Hemza, I. Rektor

. 2021 ; 144 (1) : 81-91. [pub] 20210421

Language English Country Denmark

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21025410

Grant support
AZV17-32292A Ministry of Health CR grant project
CZ.1.05/1.1.00/02.0068 "CEITEC - Central European Institute of Technology" project from the European Regional Development Fund.

OBJECTIVE: It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients. METHODS: We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. The patients were evaluated before surgery and in the first (72 patients) and/or third (57 patients) postsurgical year. The Wechsler Memory Scale III test was performed to evaluate the MQ postsurgical development. Engel's classification was used to evaluate the postsurgical seizure outcome. RESULTS: The presurgical MQ (median 88) in ≥45 years age group was significantly lower than in both younger groups (median MQ = 100 for ≤30 years age group, p = 0.002; median MQ = 107 for 31-44 years age group, p = 0.002). Three years after the surgery, the MQ decreased significantly in ≤30 years age group (p = 0.012), while only non-significant MQ decline was observed in both older groups. We found no significant impact of age on the surgical outcome. CONCLUSION: Higher age at the time of surgery does not significantly increase the risk for postsurgical memory decline; however, older patients are more likely to have lowered presurgical MQ. We did not find significant differences in the impact of surgery on seizure outcome among the age groups. Epilepsy surgery appears to be a safe and effective method in the age over 45 years even though an earlier surgery should be preferred.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21025410
003      
CZ-PrNML
005      
20211116103806.0
007      
ta
008      
211013s2021 dk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/ane.13427 $2 doi
035    __
$a (PubMed)33881170
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a dk
100    1_
$a Tyrlíková, Ivana $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic $u Mid-Atlantic Epilepsy and Sleep Center, Bethesda, MD, USA
245    10
$a Memory outcomes of temporal lobe surgery in adults aged over 45 years / $c I. Tyrlíková, Z. Hummelová, S. Goldemundová, E. Koriťáková, T. Nečasová, M. Tyrlík, M. Brázdil, J. Chrastina, J. Hemza, I. Rektor
520    9_
$a OBJECTIVE: It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients. METHODS: We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. The patients were evaluated before surgery and in the first (72 patients) and/or third (57 patients) postsurgical year. The Wechsler Memory Scale III test was performed to evaluate the MQ postsurgical development. Engel's classification was used to evaluate the postsurgical seizure outcome. RESULTS: The presurgical MQ (median 88) in ≥45 years age group was significantly lower than in both younger groups (median MQ = 100 for ≤30 years age group, p = 0.002; median MQ = 107 for 31-44 years age group, p = 0.002). Three years after the surgery, the MQ decreased significantly in ≤30 years age group (p = 0.012), while only non-significant MQ decline was observed in both older groups. We found no significant impact of age on the surgical outcome. CONCLUSION: Higher age at the time of surgery does not significantly increase the risk for postsurgical memory decline; however, older patients are more likely to have lowered presurgical MQ. We did not find significant differences in the impact of surgery on seizure outcome among the age groups. Epilepsy surgery appears to be a safe and effective method in the age over 45 years even though an earlier surgery should be preferred.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a epilepsie temporálního laloku $x diagnóza $x psychologie $x chirurgie $7 D004833
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a hipokampus $x chirurgie $7 D006624
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a paměť $x fyziologie $7 D008568
650    _2
$a poruchy paměti $x diagnóza $x psychologie $7 D008569
650    _2
$a lidé středního věku $7 D008875
650    _2
$a neurochirurgické výkony $x škodlivé účinky $x psychologie $x trendy $7 D019635
650    _2
$a předoperační péče $x metody $x psychologie $7 D011300
650    _2
$a prospektivní studie $7 D011446
650    _2
$a spánkový lalok $x chirurgie $7 D013702
650    _2
$a výsledek terapie $7 D016896
650    _2
$a Wechslerovy škály $7 D014888
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hummelová, Zuzana $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic
700    1_
$a Goldemundová, Sabina $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic
700    1_
$a Koriťáková, Eva $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Nečasová, Tereza, $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic $d 1992- $7 mub2017943671
700    1_
$a Tyrlík, Mojmír $u Department of Psychological and Brain Sciences, Columbian College of Arts and Sciences, The George Washington University, Washington, DC, USA
700    1_
$a Brázdil, Milan $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic $u Centre of Neuroscience, Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
700    1_
$a Chrastina, Jan $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic
700    1_
$a Hemza, Jan $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic
700    1_
$a Rektor, Ivan $u First Department of Neurology and Department of Neurosurgery, Brno Epilepsy Center, St. Anne's Hospital and School of Medicine, Brno, Czech Republic $u Centre of Neuroscience, Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic
773    0_
$w MED00009024 $t Acta neurologica Scandinavica $x 1600-0404 $g Roč. 144, č. 1 (2021), s. 81-91
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33881170 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211116103807 $b ABA008
999    __
$a ok $b bmc $g 1714447 $s 1145917
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 144 $c 1 $d 81-91 $e 20210421 $i 1600-0404 $m Acta neurologica Scandinavica $n Acta Neurol Scand $x MED00009024
GRA    __
$a AZV17-32292A $p Ministry of Health CR grant project
GRA    __
$a CZ.1.05/1.1.00/02.0068 $p "CEITEC - Central European Institute of Technology" project from the European Regional Development Fund.
LZP    __
$a Pubmed-20211013

Find record

Citation metrics

Archiving options