Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

Center for Developmental Biology and Reprogramming Department of Biomedical Sciences University of Sassari Viale San Pietro 43 B 07100 Sassari Italy

Department of Biomedical Sciences University of Sassari Viale San Pietro 43 B 07100 Sassari Italy

Department of Chemistry and Pharmacy University of Sassari Vienna 2 07100 Sassari Italy

Institute of Biophysics 2nd Faculty of Medicine Charles University 5 Uvalu 84 150 06 Prague 5 Czech Republic

Interuniversity Consortium 1 N B B Viale delle Medaglie d'Oro 305 00136 Roma Italy

UCEEB Czech Technical University Trinecka 1024 27343 Bustehrad Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc21025514

003      

CZ-PrNML

005      

20220322153905.0

007      

ta

008      

211013s2021 sz f 000 0|eng||

009      

AR

024    7_

$a 10.3390/ijms22137095 $2 doi

035    __

$a (PubMed)34209468

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a sz

100    1_

$a Bellu, Emanuela $u Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy

245    10

$a Nanomaterials in Skin Regeneration and Rejuvenation / $c E. Bellu, S. Medici, D. Coradduzza, S. Cruciani, E. Amler, M. Maioli

520    9_

$a Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

650    _2

$a zvířata $7 D000818

650    12

$a systémy cílené aplikace léků $7 D016503

650    _2

$a lidé $7 D006801

650    _2

$a nanostruktury $x terapeutické užití $7 D049329

650    _2

$a regenerace $x účinky léků $7 D012038

650    12

$a omlazení $7 D012060

650    _2

$a kůže $x metabolismus $7 D012867

650    _2

$a fyziologie kůže $x účinky léků $7 D012879

655    _2

$a časopisecké články $7 D016428

655    _2

$a přehledy $7 D016454

700    1_

$a Medici, Serenella $u Department of Chemistry and Pharmacy, University of Sassari, Vienna 2, 07100 Sassari, Italy

700    1_

$a Coradduzza, Donatella $u Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy

700    1_

$a Cruciani, Sara $u Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy

700    1_

$a Amler, Evzen $u UCEEB, Czech Technical University, Trinecka 1024, 27343 Bustehrad, Czech Republic $u Institute of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic

700    1_

$a Maioli, Margherita $u Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy $u Center for Developmental Biology and Reprogramming (CEDEBIOR), Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy $u Interuniversity Consortium I.N.B.B., Viale delle Medaglie d'Oro, 305, 00136 Roma, Italy $7 xx0271022

773    0_

$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 22, č. 13 (2021)

856    41

$u https://pubmed.ncbi.nlm.nih.gov/34209468 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y p $z 0

990    __

$a 20211013 $b ABA008

991    __

$a 20220322153902 $b ABA008

999    __

$a ok $b bmc $g 1714533 $s 1146021

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2021 $b 22 $c 13 $e 20210630 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142

LZP    __

$a Pubmed-20211013