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Assessment of Waldeyer's ring in pediatric and adolescent Hodgkin lymphoma patients-Importance of multimodality imaging: Results from the EuroNet-PHL-C1 trial

L. Kurch, C. Mauz-Körholz, A. Fosså, TW. Georgi, R. Kluge, JM. Bartelt, C. Kunze, WA. Wohlgemuth, T. Pelz, D. Vordermark, S. Plößl, D. Hasenclever, O. Sabri, J. Landman-Parker, WH. Wallace, J. Karlen, A. Fernández-Teijeiro, M. Cepelova, T....

. 2021 ; 68 (4) : e28903. [pub] 20210203

Jazyk angličtina Země Spojené státy americké

Typ dokumentu klinické zkoušky, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21025918

BACKGROUND: In the EuroNet Pediatric Hodgkin Lymphoma (EuroNet-PHL) trials, decision on Waldeyer's ring (WR) involvement is usually based on clinical assessment, that is, physical examination and/or nasopharyngoscopy. However, clinical assessment only evaluates mucosal surface and is prone to interobserver variability. Modern cross-sectional imaging technology may provide valuable information beyond mucosal surface, which may lead to a more accurate WR staging. PATIENTS, MATERIALS, AND METHODS: The EuroNet-PHL-C1 trial recruited 2102 patients, of which 1752 underwent central review including reference reading of their cross-sectional imaging data. In 14 of 1752 patients, WR was considered involved according to clinical assessment. In these 14 patients, the WR was re-assessed by applying an imaging-based algorithm considering information from 18 F-fluorodeoxyglucose positron emission tomography, contrast-enhanced computed tomography, and/or magnetic resonance imaging. For verification purposes, the imaging-based algorithm was applied to 100 consecutive patients whose WR was inconspicuous on clinical assessment. RESULTS: The imaging-based algorithm confirmed WR involvement only in four of the 14 patients. Of the remaining 10 patients, four had retropharyngeal lymph node involvement and six an inconspicuous WR. Applying the imaging-based algorithm to 100 consecutive patients with physiological appearance of their WR on clinical assessment, absence of WR involvement could be confirmed in 99. However, suspicion of WR involvement was raised in one patient. CONCLUSIONS: The imaging-based algorithm was feasible and easily applicable at initial staging of young patients with Hodgkin lymphoma. It increased the accuracy of WR staging, which may contribute to a more individualized treatment in the future.

Department of Ear Nose and Throat Medicine Hospital Martha Maria Halle Halle Germany

Department of Medical Oncology and Radiotherapy Oslo University Hospital Oslo Norway

Department of Nuclear Medicine Justus Liebig University Giessen Giessen Germany

Department of Nuclear Medicine University of Leipzig Leipzig Germany

Department of Paediatric Oncology Royal Hospital for Sick Children University of Edinburgh Edinburgh UK

Department of Pediatric Hematology and Oncology Justus Liebig University Gießen Germany

Department of Pediatric Hematology and Oncology Our Lady's Children's Hospital Dublin Ireland

Department of Pediatric Hematology and Oncology St Anna Children's Hospital Medical University of Vienna Vienna Austria

Department of Pediatric Hematology and Oncology University Children's Hospital Bratislava Slovakia

Department of Pediatric Hematology and Oncology University College London Hospitals London UK

Department of Pediatric Hematology and Oncology University Hospital Motol and 2nd Medical Faculty of Charles University Prague Czech Republic

Department of Pediatric Hematology and Oncology University Hospitals Leuven Leuven Belgium

Department of Radiation Oncology Medical Faculty of the Martin Luther University Halle Germany

Department of Radiation Oncology University Hospital Vienna Vienna Austria

Department of Radiology and Nuclear Medicine Oslo University Hospital Oslo Norway

Department of Radiology Justus Liebig University Giessen Giessen Germany

Department of Radiology Medical Faculty of the Martin Luther University Halle Germany

Division of Pediatrics Department of Woman Mother Child Pediatric Hematology Oncology Unit University Hospital of Lausanne Lausanne Switzerland

Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands

Hôpital Armand Trousseau Sorbonne Universitè Paris France

Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany

Institute of Pediatrics Jagiellonian University Medical College Krakow Poland

Karolinska University Hospital Astrid Lindgrens Childrens Hospital Stockholm Sweden

Medical Faculty of the Martin Luther University Halle Germany

Pediatric Onco Hematology Unit Hospital Universitario Virgen Macarena Sevilla Spain

Princess Màxima Center for Pediatric Oncology Utrecht The Netherlands

Service d'Hématologie Pédiatrique Hôpital Robert Debré Paris France

Wiener Privatklinik Radiology Centre Vienna Austria

Citace poskytuje Crossref.org

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