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Molecular Aspects of the Development and Function of Auditory Neurons
G. Pavlinkova
Language English Country Switzerland
Document type Journal Article, Review
Grant support
20-06927S
The Czech Science Foundation
86652036
the Czech Academy of Sciences RVO
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
33374462
DOI
10.3390/ijms22010131
Knihovny.cz E-resources
- MeSH
- Spiral Ganglion embryology physiology MeSH
- Induced Pluripotent Stem Cells cytology MeSH
- Cochlea embryology physiology MeSH
- Humans MeSH
- Brain Stem MeSH
- Mutation MeSH
- Mice MeSH
- Neurogenesis MeSH
- Neurons physiology MeSH
- Cochlear Nucleus embryology physiology MeSH
- Hearing Loss, Sensorineural physiopathology MeSH
- Regenerative Medicine methods MeSH
- Base Sequence MeSH
- Evoked Potentials, Auditory, Brain Stem MeSH
- Hair Cells, Auditory physiology MeSH
- Ear, Inner embryology physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric signals from sensory hair cells to the first auditory nuclei of the brain stem, the cochlear nuclei. Congenital and acquired neurosensory hearing loss affects millions of people worldwide. An increasing body of evidence suggest that the primary auditory neurons degenerate due to noise exposure and aging more readily than sensory cells, and thus, auditory neurons are a primary target for regenerative therapy. A better understanding of the development and function of these neurons is the ultimate goal for long-term maintenance, regeneration, and stem cell replacement therapy. In this review, we provide an overview of the key molecular factors responsible for the function and neurogenesis of the primary auditory neurons, as well as a brief introduction to stem cell research focused on the replacement and generation of auditory neurons.
References provided by Crossref.org
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