• Je něco špatně v tomto záznamu ?

Safety testing of adult novelties using in vitro methods

L. Svobodova, M. Dvorakova, M. Rucki, K. Kejlova, H. Kandarova, H. Kolarova, M. Mannerstrom, T. Heinonen

. 2020 ; 117 (-) : 104780. [pub] 20200906

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026469

Despite widespread and prolonged use of adult novelties, their health safety is not regularly tested or legally regulated. In the EU, adult novelties are subjected to the General Product Safety Directive, placing the burden of proof regarding safe products onto the manufacturers. The aim of our pilot study was to expand knowledge on potential application of in vitro methods for hazard prediction of extracts from final products. We subjected extracts of 20 adult novelties, purchased on the Czech market to toxicological tests including NRU cytotoxicity assay, sensitization tests DPRA and LuSens and the YES/YAS endocrine assay. Four samples produced cytotoxicity. Sensitization potential was recorded by DPRA (three samples) while the LuSens reported ten samples. Regarding endocrine disruption, three samples produced antiestrogen and antiandrogen effects. Six samples exhibited androgenic potential and one sample showed estrogenic potential. Positive results with possible health effects were recorded repeatedly for samples made of ABS, PVC and latex. The study has confirmed promising usefulness of our test methods combination with regard to safety testing of this type of consumer products. The results should be evaluated with care, however, the data bring added-value to the limited knowledge of mixture toxicology and are indicative for further testing.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21026469
003      
CZ-PrNML
005      
20211208135034.0
007      
ta
008      
211013s2020 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.yrtph.2020.104780 $2 doi
035    __
$a (PubMed)32898621
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Svobodová, Lada $u National Institute of Public Health, Prague, Šrobárova 48/49, 100 00, Prague 10, Czech Republic; Department of Medical Biophysics, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic. Electronic address: lada.svobodova@szu.cz $7 xx0267259
245    10
$a Safety testing of adult novelties using in vitro methods / $c L. Svobodova, M. Dvorakova, M. Rucki, K. Kejlova, H. Kandarova, H. Kolarova, M. Mannerstrom, T. Heinonen
520    9_
$a Despite widespread and prolonged use of adult novelties, their health safety is not regularly tested or legally regulated. In the EU, adult novelties are subjected to the General Product Safety Directive, placing the burden of proof regarding safe products onto the manufacturers. The aim of our pilot study was to expand knowledge on potential application of in vitro methods for hazard prediction of extracts from final products. We subjected extracts of 20 adult novelties, purchased on the Czech market to toxicological tests including NRU cytotoxicity assay, sensitization tests DPRA and LuSens and the YES/YAS endocrine assay. Four samples produced cytotoxicity. Sensitization potential was recorded by DPRA (three samples) while the LuSens reported ten samples. Regarding endocrine disruption, three samples produced antiestrogen and antiandrogen effects. Six samples exhibited androgenic potential and one sample showed estrogenic potential. Positive results with possible health effects were recorded repeatedly for samples made of ABS, PVC and latex. The study has confirmed promising usefulness of our test methods combination with regard to safety testing of this type of consumer products. The results should be evaluated with care, however, the data bring added-value to the limited knowledge of mixture toxicology and are indicative for further testing.
650    _2
$a zvířata $7 D000818
650    _2
$a buňky BALB 3T3 $7 D041702
650    _2
$a spotřebitelská bezpečnost produktů $x normy $7 D003257
650    _2
$a endokrinní disruptory $x toxicita $7 D052244
650    _2
$a fibroblasty $x účinky léků $x fyziologie $7 D005347
650    _2
$a lidé $7 D006801
650    _2
$a techniky in vitro $x metody $7 D066298
650    _2
$a myši $7 D051379
650    _2
$a pilotní projekty $7 D010865
650    _2
$a plastické hmoty $x toxicita $7 D010969
650    12
$a hra a hračky $7 D010988
650    _2
$a Saccharomyces cerevisiae $x účinky léků $x fyziologie $7 D012441
650    _2
$a sexuální chování $x účinky léků $x fyziologie $7 D012725
650    _2
$a testy akutní toxicity $x metody $7 D023382
655    _2
$a časopisecké články $7 D016428
700    1_
$a Dvorakova, M $u National Institute of Public Health, Prague, Šrobárova 48/49, 100 00, Prague 10, Czech Republic; Charles University in Prague, Third Faculty of Medicine, Ruská 87, 100 00, Prague 10, Czech Republic. Electronic address: marketa.dvorakova@szu.cz
700    1_
$a Rucki, M $u National Institute of Public Health, Prague, Šrobárova 48/49, 100 00, Prague 10, Czech Republic. Electronic address: marian.rucki@szu.cz
700    1_
$a Kejlova, K $u National Institute of Public Health, Prague, Šrobárova 48/49, 100 00, Prague 10, Czech Republic. Electronic address: kristina.kejlova@szu.cz
700    1_
$a Kandarova, H $u Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská Cesta 9, 841 04, Bratislava, Slovakia; Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37, Bratislava, Slovakia. Electronic address: helena.kandarova@savba.sk
700    1_
$a Kolarova, H $u Department of Medical Biophysics, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Czech Republic. Electronic address: hana.kolarova@upol.cz
700    1_
$a Mannerstrom, M $u FICAM, Faculty of Medicine and Health Technology, FI-33014 Tampere University, Tampere, Finland. Electronic address: marika.mannerstrom@tuni.fi
700    1_
$a Heinonen, T $u FICAM, Faculty of Medicine and Health Technology, FI-33014 Tampere University, Tampere, Finland. Electronic address: tuula.heinonen@tuni.fi
773    0_
$w MED00004074 $t Regulatory toxicology and pharmacology : RTP $x 1096-0295 $g Roč. 117, č. - (2020), s. 104780
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32898621 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211208135032 $b ABA008
999    __
$a ok $b bmc $g 1715249 $s 1146976
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 117 $c - $d 104780 $e 20200906 $i 1096-0295 $m Regulatory toxicology and pharmacology $n Regul Toxicol Pharmacol $x MED00004074
LZP    __
$a Pubmed-20211013

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace