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The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease

P. Jabandziev, J. Bohosova, T. Pinkasova, L. Kunovsky, O. Slaby, A. Goel

. 2020 ; 26 (7) : 985-993. [pub] 20200618

Jazyk angličtina Země Velká Británie

Typ dokumentu úvodní články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026680

Grantová podpora
R01 CA184792 NCI NIH HHS - United States
R01 CA202797 NCI NIH HHS - United States

Prevalence of inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gut, has been on the rise in recent years-not only in the adult population but also especially in pediatric patients. Despite the absence of curative treatments, current therapeutic options are able to achieve long-term remission in a significant proportion of cases. To this end, however, there is a need for biomarkers enabling accurate diagnosis, prognosis, and prediction of response to therapies to facilitate a more individualized approach to pediatric IBD patients. In recent years, evidence has continued to evolve concerning noncoding RNAs (ncRNAs) and their roles as integral factors in key immune-related cellular pathways. Specific deregulation patterns of ncRNAs have been linked to pathogenesis of various diseases, including pediatric IBD. In this article, we provide an overview of current knowledge on ncRNAs, their altered expression profiles in pediatric IBD patients, and how these are emerging as potentially valuable clinical biomarkers as we enter an era of personalized medicine.

Citace poskytuje Crossref.org

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