Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Could the CCR5-Delta32 mutation be protective in SARS-CoV-2 infection

N. Starcevic Cizmarevic, M. Kapovic, D. Roncevic, S. Ristic

. 2021 ; 70 (S2) : S249-S252. [pub] 20211216

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22000861

Increasing evidence points to host genetics as a factor in COVID-19 prevalence and outcome. CCR5 is a receptor for proinflammatory chemokines that are involved in host responses, especially to viruses. The CCR5-delta32 minor allele is an interesting variant, given the role of CCR5 in some viral infections, particularly HIV-1. Recent studies of the impact of CCR5-delta32 on COVID-19 risk and severity have yielded contradictory results. This ecologic study shows that the CCR5-delta32 allelic frequency in a European population was significantly negatively correlated with the number of COVID-19 cases (p=0.035) and deaths (p=0.006) during the second pandemic wave. These results suggest that CCR5-delta32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc22000861
003      
CZ-PrNML
005      
20220217135130.0
007      
ta
008      
220106s2021 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934725 $2 doi
035    __
$a (PubMed)34913355
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Starcevic Cizmarevic, N. $u Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
245    10
$a Could the CCR5-Delta32 mutation be protective in SARS-CoV-2 infection / $c N. Starcevic Cizmarevic, M. Kapovic, D. Roncevic, S. Ristic
504    __
$a Literatura
520    9_
$a Increasing evidence points to host genetics as a factor in COVID-19 prevalence and outcome. CCR5 is a receptor for proinflammatory chemokines that are involved in host responses, especially to viruses. The CCR5-delta32 minor allele is an interesting variant, given the role of CCR5 in some viral infections, particularly HIV-1. Recent studies of the impact of CCR5-delta32 on COVID-19 risk and severity have yielded contradictory results. This ecologic study shows that the CCR5-delta32 allelic frequency in a European population was significantly negatively correlated with the number of COVID-19 cases (p=0.035) and deaths (p=0.006) during the second pandemic wave. These results suggest that CCR5-delta32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.
650    _2
$a COVID-19 $x genetika $x imunologie $x mortalita $x virologie $7 D000086382
650    _2
$a frekvence genu $7 D005787
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a interakce hostitele a patogenu $7 D054884
650    _2
$a lidé $7 D006801
650    12
$a mutace $7 D009154
650    _2
$a fenotyp $7 D010641
650    _2
$a prevalence $7 D015995
650    _2
$a ochranné faktory $7 D065840
650    _2
$a receptory CCR5 $x genetika $7 D019713
650    _2
$a rizikové faktory $7 D012307
650    _2
$a SARS-CoV-2 $x imunologie $x patogenita $7 D000086402
650    _2
$a stupeň závažnosti nemoci $7 D012720
651    _2
$a Evropa $x epidemiologie $7 D005060
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kapovic, M. $u Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
700    1_
$a Roncevic, D. $u Dobrica Rončević, Primorje-Gorski Kotar County Teaching Institute of Public Health, Rijeka, Croatia
700    1_
$a Ristic, S. $u Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 70, Suppl. 2 (2021), s. S249-S252
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34913355 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20220106 $b ABA008
991    __
$a 20220217135124 $b ABA008
999    __
$a ok $b bmc $g 1761108 $s 1152007
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 70 $c S2 $d S249-S252 $e 20211216 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20220106

Find record

Citation metrics

Archiving options