-
Je něco špatně v tomto záznamu ?
Donor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool
M. Kauke, V. Haug, D. Obed, Y. Diehm, B. Tchiloemba, AF. Safi, B. Pomahac
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- časové faktory MeSH
- cytomegalovirové infekce krev diagnóza epidemiologie přenos MeSH
- Cytomegalovirus izolace a purifikace MeSH
- dospělí MeSH
- Hepacivirus izolace a purifikace MeSH
- hepatitida C krev diagnóza epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- retrospektivní studie MeSH
- senioři MeSH
- seznamy čekatelů MeSH
- vaskularizovaná kompozitní alotransplantace normy statistika a číselné údaje MeSH
- výběr dárců normy statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Identifying a donor for facial vascularized composite allotransplant recipients can be a lengthy, emotionally challenging process. Little is known about the relative distribution of key donor characteristics among potential donors. Data on actual wait times of patients are limited, making it difficult to estimate wait times for future recipients. METHODS: The authors retrospectively reviewed charts of nine facial vascularized composite allotransplant patients and provide data on transplant wait times and patient characteristics. In addition, they analyzed the United Network for Organ Sharing database of dead organ donors. After excluding donors with high-risk characteristics (e.g., active cancer or risk factors for blood-borne disease transmission), the authors calculated the distribution of relevant donor-recipient matching criteria (i.e., ethnicity, body mass index, age, ABO blood group, cytomegalovirus, Epstein-Barr virus, hepatitis C virus) among 65,201 potential donors. RESULTS: The median wait time for a transplant was 4 months (range, 1 day to 17 months). The large majority of United Network for Organ Sharing-recorded deaths from disease were white (63 percent) and male (58 percent). Female donors of black, Hispanic, or Asian descent are underrepresented, with 7, 5, and 1 percent of all recorded deaths from disease, respectively. Potential donors show cytomegalovirus and Epstein-Barr virus seropositivity of 65 and 95 percent, respectively. The number of annual hepatitis C-positive donors increased over time. CONCLUSIONS: Actual facial vascularized composite allotransplant wait times vary considerably. Although most patients experience acceptable wait times, some with underrepresented characteristics exceed acceptable levels. Cytomegalovirus-seropositive donors present a large portion of the donor pool, and exclusion for seronegative patients may increase wait time. Hepatitis C-seropositive donors may constitute a donor pool for underrepresented patient groups in the future.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22000894
- 003
- CZ-PrNML
- 005
- 20220106132548.0
- 007
- ta
- 008
- 220106s2021 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/PRS.0000000000008094 $2 doi
- 035 __
- $a (PubMed)34181616
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Kauke, Martin $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg
- 245 10
- $a Donor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool / $c M. Kauke, V. Haug, D. Obed, Y. Diehm, B. Tchiloemba, AF. Safi, B. Pomahac
- 520 9_
- $a BACKGROUND: Identifying a donor for facial vascularized composite allotransplant recipients can be a lengthy, emotionally challenging process. Little is known about the relative distribution of key donor characteristics among potential donors. Data on actual wait times of patients are limited, making it difficult to estimate wait times for future recipients. METHODS: The authors retrospectively reviewed charts of nine facial vascularized composite allotransplant patients and provide data on transplant wait times and patient characteristics. In addition, they analyzed the United Network for Organ Sharing database of dead organ donors. After excluding donors with high-risk characteristics (e.g., active cancer or risk factors for blood-borne disease transmission), the authors calculated the distribution of relevant donor-recipient matching criteria (i.e., ethnicity, body mass index, age, ABO blood group, cytomegalovirus, Epstein-Barr virus, hepatitis C virus) among 65,201 potential donors. RESULTS: The median wait time for a transplant was 4 months (range, 1 day to 17 months). The large majority of United Network for Organ Sharing-recorded deaths from disease were white (63 percent) and male (58 percent). Female donors of black, Hispanic, or Asian descent are underrepresented, with 7, 5, and 1 percent of all recorded deaths from disease, respectively. Potential donors show cytomegalovirus and Epstein-Barr virus seropositivity of 65 and 95 percent, respectively. The number of annual hepatitis C-positive donors increased over time. CONCLUSIONS: Actual facial vascularized composite allotransplant wait times vary considerably. Although most patients experience acceptable wait times, some with underrepresented characteristics exceed acceptable levels. Cytomegalovirus-seropositive donors present a large portion of the donor pool, and exclusion for seronegative patients may increase wait time. Hepatitis C-seropositive donors may constitute a donor pool for underrepresented patient groups in the future.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a Cytomegalovirus $x izolace a purifikace $7 D003587
- 650 _2
- $a cytomegalovirové infekce $x krev $x diagnóza $x epidemiologie $x přenos $7 D003586
- 650 _2
- $a výběr dárců $x normy $x statistika a číselné údaje $7 D046148
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a Hepacivirus $x izolace a purifikace $7 D016174
- 650 _2
- $a hepatitida C $x krev $x diagnóza $x epidemiologie $7 D006526
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a časové faktory $7 D013997
- 650 _2
- $a vaskularizovaná kompozitní alotransplantace $x normy $x statistika a číselné údaje $7 D063986
- 650 _2
- $a seznamy čekatelů $7 D014850
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Haug, Valentin $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg
- 700 1_
- $a Obed, Doha $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg
- 700 1_
- $a Diehm, Yannick $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg
- 700 1_
- $a Tchiloemba, Bianief $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg
- 700 1_
- $a Safi, Ali-Farid $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg
- 700 1_
- $a Pomahač, Bohdan $u From the Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School; and the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg $d 1971- $7 xx0117402
- 773 0_
- $w MED00010436 $t Plastic and reconstructive surgery $x 1529-4242 $g Roč. 148, č. 1 (2021), s. 194-202
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34181616 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220106 $b ABA008
- 991 __
- $a 20220106132545 $b ABA008
- 999 __
- $a ok $b bmc $g 1743229 $s 1152040
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 148 $c 1 $d 194-202 $e 2021Jul01 $i 1529-4242 $m Plastic and reconstructive surgery $n Plast Reconstr Surg $x MED00010436
- LZP __
- $a Pubmed-20220106