• Je něco špatně v tomto záznamu ?

Colon cancer patients with mismatch repair deficiency are more likely to present as acute surgical cases

I. Gkekas, J. Novotny, T. Kaprio, I. Beilmann-Lehtonen, P. Fabian, S. Edin, K. Strigård, T. Svoboda, J. Hagström, L. Barsova, T. Jirasek, C. Haglund, R. Palmqvist, U. Gunnarsson

. 2021 ; 157 (-) : 1-9. [pub] 20210827

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003295

BACKGROUND: The effect of the genetic imprint on the emergency presentation of colon cancer remains unclear. The disparity between tumours evolving along different carcinogenetic pathways has not been studied systematically. This retrospective multicenter cohort study evaluates the association between mismatch repair status and the risk for acute surgery of colon cancer. PATIENTS AND METHODS: A retrospective multicenter cohort study including in total 870 patients from three different countries. Scandinavian cohort (Finland and Sweden), including a total of 412 patients operated between January 1, 1995 and December 31, 2010, was validated against a cohort from the Czech Republic, including a total of 458 patients, operated between January 1, 2018 and December 31, 2019. The proficiency or deficiency of mismatch repair was determined by immunohistochemistry. Primary outcome was the risk for acute colon cancer surgery given as the Odds Ratio (OR) in the univariable and multivariable analyses. Acute colon cancer surgery was defined as surgery performed during the same hospital admission as when the diagnosis of colon cancer was made. RESULTS: Of the 870 patients (399 females [46%]) included in the analyses, median age at surgery was 69 [interquartile range, 61-76] years, deficient Mismatch Repair (dMMR) status was found in 190 patients (22%), and 179 patients (21%) underwent acute surgery during the same hospital admission as when the diagnosis of colon cancer was made. In the Scandinavian cohort, a significant association between dMMR status and acute surgery was seen in both the univariable (OR 1.82, 95% CI 1.11-3.02, P = 0.017) and the multivariable (OR = 2.21, 95% CI 1.28-3.95, P = 0.005) analyses. This was confirmed in the Czech validation cohort in both the univariable (OR = 1.94, 95% CI 1.09-3.26, P = 0.022) and the multivariable (OR = 1.77, 95% CI 1.15-3.18, P = 0.021) analyses. CONCLUSION: This multicenter study reveals a strong association between acute colon cancer surgery and dMMR tumour status.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22003295
003      
CZ-PrNML
005      
20220127150502.0
007      
ta
008      
220113s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ejca.2021.07.027 $2 doi
035    __
$a (PubMed)34461577
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Gkekas, Ioannis $u Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. Electronic address: ioannis.gkekas@regionvasterbotten.se
245    10
$a Colon cancer patients with mismatch repair deficiency are more likely to present as acute surgical cases / $c I. Gkekas, J. Novotny, T. Kaprio, I. Beilmann-Lehtonen, P. Fabian, S. Edin, K. Strigård, T. Svoboda, J. Hagström, L. Barsova, T. Jirasek, C. Haglund, R. Palmqvist, U. Gunnarsson
520    9_
$a BACKGROUND: The effect of the genetic imprint on the emergency presentation of colon cancer remains unclear. The disparity between tumours evolving along different carcinogenetic pathways has not been studied systematically. This retrospective multicenter cohort study evaluates the association between mismatch repair status and the risk for acute surgery of colon cancer. PATIENTS AND METHODS: A retrospective multicenter cohort study including in total 870 patients from three different countries. Scandinavian cohort (Finland and Sweden), including a total of 412 patients operated between January 1, 1995 and December 31, 2010, was validated against a cohort from the Czech Republic, including a total of 458 patients, operated between January 1, 2018 and December 31, 2019. The proficiency or deficiency of mismatch repair was determined by immunohistochemistry. Primary outcome was the risk for acute colon cancer surgery given as the Odds Ratio (OR) in the univariable and multivariable analyses. Acute colon cancer surgery was defined as surgery performed during the same hospital admission as when the diagnosis of colon cancer was made. RESULTS: Of the 870 patients (399 females [46%]) included in the analyses, median age at surgery was 69 [interquartile range, 61-76] years, deficient Mismatch Repair (dMMR) status was found in 190 patients (22%), and 179 patients (21%) underwent acute surgery during the same hospital admission as when the diagnosis of colon cancer was made. In the Scandinavian cohort, a significant association between dMMR status and acute surgery was seen in both the univariable (OR 1.82, 95% CI 1.11-3.02, P = 0.017) and the multivariable (OR = 2.21, 95% CI 1.28-3.95, P = 0.005) analyses. This was confirmed in the Czech validation cohort in both the univariable (OR = 1.94, 95% CI 1.09-3.26, P = 0.022) and the multivariable (OR = 1.77, 95% CI 1.15-3.18, P = 0.021) analyses. CONCLUSION: This multicenter study reveals a strong association between acute colon cancer surgery and dMMR tumour status.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a nádory mozku $x komplikace $7 D001932
650    _2
$a nádory tračníku $x genetika $x patologie $x chirurgie $7 D003110
650    _2
$a kolorektální nádory $x komplikace $7 D015179
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a staging nádorů $7 D009367
650    _2
$a dědičné nádorové syndromy $x komplikace $7 D009386
650    _2
$a retrospektivní studie $7 D012189
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Novotny, Jan $u Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
700    1_
$a Kaprio, Tuomas $u Department of Gastrointestinal Surgery, University of Helsinki and Helsinki University Hospital, Finland
700    1_
$a Beilmann-Lehtonen, Ines $u Department of Transplantation and Liver Surgery, University of Helsinki and Helsinki University Hospital, Finland
700    1_
$a Fabian, Pavel $u Department of Oncological Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
700    1_
$a Edin, Sofia $u Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden
700    1_
$a Strigård, Karin $u Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
700    1_
$a Svoboda, Tomas $u Department of Oncology and Radiotherapy, Faculty Hospital Pilsen, Charles University, Prague, Czech Republic
700    1_
$a Hagström, Jaana $u Department of Pathology, University of Helsinki, Finland; Department of Oral Pathology and Radiology, University of Turku, Finland
700    1_
$a Barsova, Lucie $u Comprehensive Oncology Center, Liberec, Czech Republic
700    1_
$a Jirasek, Tomas $u Department of Pathology, Liberec, Czech Republic
700    1_
$a Haglund, Caj $u Department of Gastrointestinal Surgery, University of Helsinki and Helsinki University Hospital, Finland
700    1_
$a Palmqvist, Richard $u Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden
700    1_
$a Gunnarsson, Ulf $u Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
773    0_
$w MED00009626 $t European journal of cancer (Oxford, England : 1990) $x 1879-0852 $g Roč. 157, č. - (2021), s. 1-9
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34461577 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127150458 $b ABA008
999    __
$a ok $b bmc $g 1750912 $s 1154444
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 157 $c - $d 1-9 $e 20210827 $i 1879-0852 $m European journal of cancer $n Eur J Cancer $x MED00009626
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace