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Low-Carbohydrate Diet among Children with Type 1 Diabetes: A Multi-Center Study

V. Neuman, L. Plachy, S. Pruhova, S. Kolouskova, L. Petruzelkova, B. Obermannova, J. Vyzralkova, P. Konecna, J. Vosahlo, M. Romanova, M. Pavlikova, Z. Sumnik

. 2021 ; 13 (11) : . [pub] 20211030

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003385

Grantová podpora
AZV grant NU21-01-00085 Ministry of Health of the Czech Republic

AIMS/HYPOTHESIS: The proportion of children with type 1 diabetes (T1D) who have experience with low-carbohydrate diet (LCD) is unknown. Our goal was to map the frequency of LCD among children with T1D and to describe their clinical and laboratory data. METHODS: Caregivers of 1040 children with T1D from three centers were addressed with a structured questionnaire regarding the children's carbohydrate intake and experience with LCD (daily energy intake from carbohydrates below 26% of age-recommended values). The subjects currently on LCD were compared to a group of non-LCD respondents matched to age, T1D duration, sex, type and center of treatment. RESULTS: A total of 624/1040 (60%) of the subjects completed the survey. A total of 242/624 (39%) subjects reported experience with voluntary carbohydrate restriction with 36/624 (5.8%) subjects currently following the LCD. The LCD group had similar HbA1c (45 vs. 49.5, p = 0.11), lower average glycemia (7.0 vs. 7.9, p = 0.02), higher time in range (74 vs. 67%, p = 0.02), lower time in hyperglycemia >10 mmol/L (17 vs. 20%, p = 0.04), tendency to more time in hypoglycemia <3.9 mmol/L(8 vs. 5%, p = 0.05) and lower systolic blood pressure percentile (43 vs. 74, p = 0.03). The groups did not differ in their lipid profile nor in current body height, weight or BMI. The LCD was mostly initiated by the parents or the subjects themselves and only 39% of the families consulted their decision with the diabetologist. CONCLUSIONS/INTERPRETATION: Low carbohydrate diet is not scarce in children with T1D and is associated with modestly better disease control. At the same time, caution should be applied as it showed a tendency toward more frequent hypoglycemia.

Citace poskytuje Crossref.org

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$a Plachy, Lukas $u Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, CZ-15006 Prague, Czech Republic
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$a Pruhova, Stepanka $u Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, CZ-15006 Prague, Czech Republic
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$a Kolouskova, Stanislava $u Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, CZ-15006 Prague, Czech Republic
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$a Petruzelkova, Lenka $u Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, CZ-15006 Prague, Czech Republic
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$a Obermannova, Barbora $u Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, CZ-15006 Prague, Czech Republic
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$a Konecna, Petra $u Department of Pediatrics, University Hospital Brno, CZ-62500 Brno, Czech Republic
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$a Vosahlo, Jan $u Department of Pediatrics, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, CZ-10034 Prague, Czech Republic
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$a Romanova, Martina $u Department of Pediatrics, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, CZ-10034 Prague, Czech Republic
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$a Pavlikova, Marketa $u Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University, CZ-18675 Prague, Czech Republic
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$a Sumnik, Zdenek $u Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, CZ-15006 Prague, Czech Republic
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