• Je něco špatně v tomto záznamu ?

Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review

M. Čoma, V. Lachová, P. Mitrengová, P. Gál

. 2021 ; 43 (1) : 127-141. [pub] 20210517

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004340

Grantová podpora
APVV-16-0207 Agentúra na Podporu Výskumu a Vývoja

Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004340
003      
CZ-PrNML
005      
20240716102409.0
007      
ta
008      
220113s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/cimb43010011 $2 doi
035    __
$a (PubMed)34067763
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Čoma, Matúš $u Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia $u Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia
245    10
$a Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review / $c M. Čoma, V. Lachová, P. Mitrengová, P. Gál
520    9_
$a Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.
650    _2
$a zvířata $7 D000818
650    _2
$a genistein $x farmakologie $7 D019833
650    _2
$a lidé $7 D006801
650    _2
$a fytoestrogeny $x farmakologie $7 D048789
650    _2
$a regenerativní lékařství $x trendy $7 D044968
650    _2
$a selektivní modulátory estrogenních receptorů $x farmakologie $7 D020845
650    _2
$a signální transdukce $7 D015398
650    _2
$a hojení ran $x účinky léků $7 D014945
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Lachová, Veronika $u Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovakia
700    1_
$a Mitrengová, Petra $u Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovakia
700    1_
$a Gál, Peter, $u Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia $u Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovakia $u Laboratory of Cell Interactions, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia $u Prague Burn Center, Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic $d 1981- $7 xx0320027
773    0_
$w MED00173547 $t Current issues in molecular biology $x 1467-3045 $g Roč. 43, č. 1 (2021), s. 127-141
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34067763 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20240716102406 $b ABA008
999    __
$a ok $b bmc $g 1751716 $s 1155489
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 43 $c 1 $d 127-141 $e 20210517 $i 1467-3045 $m Current issues in molecular biology $n Curr Issues Mol Biol $x MED00173547
GRA    __
$a APVV-16-0207 $p Agentúra na Podporu Výskumu a Vývoja
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...