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Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review
M. Čoma, V. Lachová, P. Mitrengová, P. Gál
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy
Grantová podpora
APVV-16-0207
Agentúra na Podporu Výskumu a Vývoja
NLK
Directory of Open Access Journals
od 1999
Free Medical Journals
od 1999
PubMed Central
od 2021
ROAD: Directory of Open Access Scholarly Resources
od 1999
PubMed
34067763
DOI
10.3390/cimb43010011
Knihovny.cz E-zdroje
- MeSH
- fytoestrogeny farmakologie MeSH
- genistein farmakologie MeSH
- hojení ran účinky léků MeSH
- lidé MeSH
- regenerativní lékařství trendy MeSH
- selektivní modulátory estrogenních receptorů farmakologie MeSH
- signální transdukce MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.
Department of Pharmacology Faculty of Medicine Pavol Jozef Šafárik University 040 11 Košice Slovakia
Prague Burn Center 3rd Faculty of Medicine Charles University 100 34 Prague Czech Republic
Citace poskytuje Crossref.org
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