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LncRNAs in adaptive immunity: role in physiological and pathological conditions
PF. Zeni, M. Mraz
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
NLK
Free Medical Journals
from 2004 to 1 year ago
Freely Accessible Science Journals
from 2004
PubMed Central
from 2009 to 1 year ago
Europe PubMed Central
from 2009 to 1 year ago
- MeSH
- Adaptive Immunity genetics MeSH
- Lymphocyte Activation genetics MeSH
- Humans MeSH
- Disease genetics MeSH
- RNA, Long Noncoding genetics physiology MeSH
- Signal Transduction genetics immunology MeSH
- T-Lymphocytes physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NFκB, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.
Faculty of Science Masaryk University Brno Czech Republic
Molecular Medicine Central European Institute of Technology Masaryk University Brno Czech Republic
References provided by Crossref.org
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