-
Je něco špatně v tomto záznamu ?
Corneal confocal microscopy differentiates inflammatory from diabetic neuropathy
M. Fleischer, I. Lee, F. Erdlenbruch, L. Hinrichs, IN. Petropoulos, RA. Malik, HP. Hartung, BC. Kieseier, C. Kleinschnitz, M. Stettner
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
BioMedCentral Open Access od 2004
Directory of Open Access Journals od 2004
Free Medical Journals od 2004
PubMed Central od 2004
Europe PubMed Central od 2004
ProQuest Central od 2009-01-01
Open Access Digital Library od 2004-04-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-01-01
Health & Medicine (ProQuest) od 2009-01-01
Springer Journals Complete - Open Access od 2004-12-01
Springer Nature OA/Free Journals od 2004-12-01
Odkazy
PubMed
33832507
DOI
10.1186/s12974-021-02130-1
Knihovny.cz E-zdroje
- MeSH
- chronická zánětlivá demyelinizační polyneuropatie diagnóza epidemiologie MeSH
- dendrity patologie MeSH
- diabetes mellitus 2. typu diagnóza epidemiologie MeSH
- diabetické neuropatie diagnóza epidemiologie MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- konfokální mikroskopie metody normy MeSH
- lidé středního věku MeSH
- lidé MeSH
- nervová vlákna patologie MeSH
- rohovka patologie MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Immune-mediated neuropathies, such as chronic inflammatory demyelinating polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic neuropathy, it remains a challenge to identify those individuals who develop CIDP. Corneal confocal microscopy (CCM) has been shown to detect corneal nerve fiber loss and cellular infiltrates in the sub-basal layer of the cornea. The objective of the study was to determine whether CCM can distinguish diabetic neuropathy from CIDP and whether CCM can detect CIDP in persons with coexisting diabetes. METHODS: In this multicenter, case-control study, participants with CIDP (n = 55) with (n = 10) and without (n = 45) diabetes; participants with diabetes (n = 58) with (n = 28) and without (n = 30) diabetic neuropathy, and healthy controls (n = 58) underwent CCM. Corneal nerve fiber density (CNFD), corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), and dendritic and non-dendritic cell density, with or without nerve fiber contact were quantified. RESULTS: Dendritic cell density in proximity to corneal nerve fibers was significantly higher in participants with CIDP with and without diabetes compared to participants with diabetic neuropathy and controls. CNFD, CNFL, and CNBD were equally reduced in participants with CIDP, diabetic neuropathy, and CIDP with diabetes. CONCLUSIONS: An increase in dendritic cell density identifies persons with CIDP. CCM may, therefore, be useful to differentiate inflammatory from non-inflammatory diabetic neuropathy.
Brain and Mind Centre University of Sydney Sydney Australia
Department of Cardiology University Hospital Essen University Duisburg Essen Essen Germany
Department of Neurology Medical Faculty Heinrich Heine University Düsseldorf Germany
Department of Neurology Palacky University Olomouc Czech Republic
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22004464
- 003
- CZ-PrNML
- 005
- 20220127145221.0
- 007
- ta
- 008
- 220113s2021 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1186/s12974-021-02130-1 $2 doi
- 035 __
- $a (PubMed)33832507
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Fleischer, Michael $u Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Hospital Essen, University Duisburg-Essen, Essen, Germany
- 245 10
- $a Corneal confocal microscopy differentiates inflammatory from diabetic neuropathy / $c M. Fleischer, I. Lee, F. Erdlenbruch, L. Hinrichs, IN. Petropoulos, RA. Malik, HP. Hartung, BC. Kieseier, C. Kleinschnitz, M. Stettner
- 520 9_
- $a BACKGROUND: Immune-mediated neuropathies, such as chronic inflammatory demyelinating polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic neuropathy, it remains a challenge to identify those individuals who develop CIDP. Corneal confocal microscopy (CCM) has been shown to detect corneal nerve fiber loss and cellular infiltrates in the sub-basal layer of the cornea. The objective of the study was to determine whether CCM can distinguish diabetic neuropathy from CIDP and whether CCM can detect CIDP in persons with coexisting diabetes. METHODS: In this multicenter, case-control study, participants with CIDP (n = 55) with (n = 10) and without (n = 45) diabetes; participants with diabetes (n = 58) with (n = 28) and without (n = 30) diabetic neuropathy, and healthy controls (n = 58) underwent CCM. Corneal nerve fiber density (CNFD), corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), and dendritic and non-dendritic cell density, with or without nerve fiber contact were quantified. RESULTS: Dendritic cell density in proximity to corneal nerve fibers was significantly higher in participants with CIDP with and without diabetes compared to participants with diabetic neuropathy and controls. CNFD, CNFL, and CNBD were equally reduced in participants with CIDP, diabetic neuropathy, and CIDP with diabetes. CONCLUSIONS: An increase in dendritic cell density identifies persons with CIDP. CCM may, therefore, be useful to differentiate inflammatory from non-inflammatory diabetic neuropathy.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a rohovka $x patologie $7 D003315
- 650 _2
- $a dendrity $x patologie $7 D003712
- 650 _2
- $a diabetes mellitus 2. typu $x diagnóza $x epidemiologie $7 D003924
- 650 _2
- $a diabetické neuropatie $x diagnóza $x epidemiologie $7 D003929
- 650 _2
- $a diferenciální diagnóza $7 D003937
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a konfokální mikroskopie $x metody $x normy $7 D018613
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a nervová vlákna $x patologie $7 D009412
- 650 _2
- $a chronická zánětlivá demyelinizační polyneuropatie $x diagnóza $x epidemiologie $7 D020277
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Lee, Inn $u Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
- 700 1_
- $a Erdlenbruch, Friedrich $u Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Hospital Essen, University Duisburg-Essen, Essen, Germany
- 700 1_
- $a Hinrichs, Lena $u Department of Cardiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
- 700 1_
- $a Petropoulos, Ioannis N $u Institute of Cardiovascular Science, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK $u Weill Cornell Medicine-Qatar, Educator City, Doha, Qatar
- 700 1_
- $a Malik, Rayaz A $u Institute of Cardiovascular Science, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK $u Weill Cornell Medicine-Qatar, Educator City, Doha, Qatar
- 700 1_
- $a Hartung, Hans-Peter $u Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany $u Brain and Mind Centre, University of Sydney, Sydney, Australia $u Medical University Vienna, Vienna, Austria $u Department of Neurology, Palacky University, Olomouc, Czech Republic
- 700 1_
- $a Kieseier, Bernd C $u Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany
- 700 1_
- $a Kleinschnitz, Christoph $u Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Hospital Essen, University Duisburg-Essen, Essen, Germany
- 700 1_
- $a Stettner, Mark $u Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Hospital Essen, University Duisburg-Essen, Essen, Germany. mark.stettner@uk-essen.de
- 773 0_
- $w MED00163330 $t Journal of neuroinflammation $x 1742-2094 $g Roč. 18, č. 1 (2021), s. 89
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33832507 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220113 $b ABA008
- 991 __
- $a 20220127145217 $b ABA008
- 999 __
- $a ok $b bmc $g 1751813 $s 1155613
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 18 $c 1 $d 89 $e 20210408 $i 1742-2094 $m Journal of neuroinflammation $n J Neuroinflammation $x MED00163330
- LZP __
- $a Pubmed-20220113