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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

MA. Munn-Chernoff, EC. Johnson, YL. Chou, JRI. Coleman, LM. Thornton, RK. Walters, Z. Yilmaz, JH. Baker, C. Hübel, S. Gordon, SE. Medland, HJ. Watson, HA. Gaspar, J. Bryois, A. Hinney, VM. Leppä, M. Mattheisen, S. Ripke, S. Yao, P....

. 2021 ; 26 (1) : e12880. [pub] 20200216

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004676

Grantová podpora
R01 MH100549 NIMH NIH HHS - United States
R01 DA032015 NIDA NIH HHS - United States
T32 AA007464 NIAAA NIH HHS - United States
R01 DA042090 NIDA NIH HHS - United States
R01 AA013321 NIAAA NIH HHS - United States
R03 HD097630 NICHD NIH HHS - United States
R01 DA024417 NIDA NIH HHS - United States
R01 DA012854 NIDA NIH HHS - United States
R01 MH123619 NIMH NIH HHS - United States
MC_UU_00007/10 Medical Research Council - United Kingdom
R01 DA037558 NIDA NIH HHS - United States
R01 DA005147 NIDA NIH HHS - United States
R01 DA036216 NIDA NIH HHS - United States
K24 DA032555 NIDA NIH HHS - United States
R37 AA009367 NIAAA NIH HHS - United States
K02 DA032573 NIDA NIH HHS - United States
R01 DA035804 NIDA NIH HHS - United States
P01 HD031921 NICHD NIH HHS - United States
P20 AA017830 NIAAA NIH HHS - United States
U01 AA027487 NIAAA NIH HHS - United States
K01 MH109782 NIMH NIH HHS - United States
R01 DA012690 NIDA NIH HHS - United States
K01 MH106675 NIMH NIH HHS - United States
R21 AA022717 NIAAA NIH HHS - United States
P50 AA011998 NIAAA NIH HHS - United States
R01 HD060726 NICHD NIH HHS - United States
UL1 TR001863 NCATS NIH HHS - United States
R01 DA024413 NIDA NIH HHS - United States
R01 GM126479 NIGMS NIH HHS - United States
K01 AA025113 NIAAA NIH HHS - United States
R01 DA021905 NIDA NIH HHS - United States
R21 DA040177 NIDA NIH HHS - United States
R01 HD073342 NICHD NIH HHS - United States
R01 AA017444 NIAAA NIH HHS - United States
R01 DA038076 NIDA NIH HHS - United States
K01 DA037914 NIDA NIH HHS - United States
R01 HD093651 NICHD NIH HHS - United States
R21 AA025214 NIAAA NIH HHS - United States
R01 DA025109 NIDA NIH HHS - United States
R01 HG008983 NHGRI NIH HHS - United States
R21 AA024888 NIAAA NIH HHS - United States
P30 DA023026 NIDA NIH HHS - United States
R01 DA036583 NIDA NIH HHS - United States
U01 MH109514 NIMH NIH HHS - United States
P50 AA022537 NIAAA NIH HHS - United States
K01 AA024152 NIAAA NIH HHS - United States
K02 AA018755 NIAAA NIH HHS - United States
R37 AA011408 NIAAA NIH HHS - United States
R01 MH066140 NIMH NIH HHS - United States
K01 MH093731 NIMH NIH HHS - United States
R00 DA023549 NIDA NIH HHS - United States
R01 MH124871 NIMH NIH HHS - United States
R01 AA012502 NIAAA NIH HHS - United States
R01 DA037904 NIDA NIH HHS - United States
R01 DA036523 NIDA NIH HHS - United States
P50 DA037844 NIDA NIH HHS - United States
K01 MH113848 NIMH NIH HHS - United States
U01 MH109532 NIMH NIH HHS - United States
Wellcome Trust - United Kingdom
R01 DA011301 NIDA NIH HHS - United States
U01 MH109539 NIMH NIH HHS - United States
F32 AA027435 NIAAA NIH HHS - United States
R01 AA015416 NIAAA NIH HHS - United States
R01 AA011408 NIAAA NIH HHS - United States
P2C HD066613 NICHD NIH HHS - United States
R37 AA007728 NIAAA NIH HHS - United States
U01 MH094432 NIMH NIH HHS - United States
R01 DA030005 NIDA NIH HHS - United States
R01 DA002812 NIDA NIH HHS - United States
P2C HD050924 NICHD NIH HHS - United States
K01 MH109765 NIMH NIH HHS - United States
R01 MH092793 NIMH NIH HHS - United States
R01 DA016977 NIDA NIH HHS - United States
U01 MH109528 NIMH NIH HHS - United States
R01 AA013320 NIAAA NIH HHS - United States
P60 DA011015 NIDA NIH HHS - United States
R01 DA013240 NIDA NIH HHS - United States

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

1st Psychiatric Department National and Kapodistrian University of Athens Medical School Eginition Hospital Athens Greece

Aberdeen Biomedical Imaging Centre School of Medicine Medical Sciences and Nutrition University of Aberdeen Foresterhill Aberdeen UK

Addictions Department Institute of Psychiatry Psychology and Neuroscience King's College London London UK

Adolescent Health Unit 2nd Department of Pediatrics P and A Kyriakou Children's Hospital University of Athens Athens Greece

Altrecht Eating Disorders Rintveld Altrecht Mental Health Institute Zeist The Netherlands

Analytic and Translational Genetics Unit Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA

Barcelona Institute of Science and Technology Barcelona Spain

BESE Division King Abdullah University of Science and Technology Thuwal Saudi Arabia

Bioinformatics Research Centre Aarhus University Aarhus Denmark

Biological Psychiatry Laboratory McLean Hospital Harvard Medical School Boston Massachusetts USA

BioRealm LLC Walnut California USA

Biostatistics and Computational Biology Unit University of Otago Christchurch New Zealand

Brain Sciences Department Stremble Ventures Limassol Cyprus

Canterbury District Health Board Christchurch New Zealand

Carolina Population Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

Center for Applied Genomics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

Center for Eating Disorders Rintveld Altrecht Mental Health Institute Zeist The Netherlands

Center for Eating Disorders Ursula Rivierduinen Leiden The Netherlands

Center for Human Genome Research Massachusetts General Hospital Boston Massachusetts USA

Center for Integrative Genomics University of Lausanne Lausanne Switzerland

Center for Neurobehavioral Genetics Semel Institute for Neuroscience and Human Behavior University of California Los Angeles Los Angeles California USA

Center for Omics Discovery and Epidemiology Behavioral Health Research Division RTI International Research Triangle Park North Carolina USA

Center for Psychiatry Research Stockholm Health Care Services Stockholm County Council Stockholm Sweden

Center for Studies of Addiction University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

Centre for Addiction and Mental Health Toronto Ontario Canada

Centre for Human Genetics University of Marburg Marburg Germany

Centre for Integrated Register based Research Aarhus University Aarhus Denmark

Centre for Integrative Sequencing iSEQ Aarhus University Aarhus Denmark

Centre for Mental Health University Health Network Toronto Ontario Canada

Centre of Psychiatry and Neuroscience INSERM U894 Paris France

Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública Barcelona Spain

Christchurch Health and Development Study University of Otago Christchurch New Zealand

Clinical Genetics Unit Department of Woman and Child Health University of Padova Italy

CMME Paris Descartes University Paris France

College Behavioral and Emotional Health Institute Virginia Commonwealth University Richmond Virginia USA

College of Nursing Seattle University Seattle Washington USA

David Geffen School of Medicine University of California Los Angeles Los Angeles California USA

Department of Addictive Behavior and Addiction Medicine Central Institute of Mental Health Medical Faculty Mannheim Heidelberg University Mannheim Germany

Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland

Department of Behavioral Medicine National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira Tokyo Japan

Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis Indiana USA

Department of Biological Psychology Amsterdam Public Health Research Institute Vrije Universiteit Amsterdam Amsterdam The Netherlands

Department of Biomedicine Aarhus University Aarhus Denmark

Department of Biomedicine University of Basel Basel Switzerland

Department of Biometry University of Helsinki Helsinki Finland

Department of Biostatistics School of Public Health Boston University Boston Massachusetts USA

Department of Biostatistics Yale School of Public Health Yale University New Haven Connecticut USA

Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic

Department of Cancer Epidemiology and Prevention M Skłodowska Curie Cancer Center Oncology Center Warsaw Poland

Department of Child and Adolescent Psychiatry Faculty of Medicine Eating Disorders Research and Treatment Center Technische Universität Dresden Dresden Germany

Department of Child and Adolescent Psychiatry Poznan University of Medical Sciences Poznan Poland

Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy Centre for Mental Health University Hospital of Würzburg Würzburg Germany

Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy RWTH Aachen University Aachen Germany

Department of Child and Adolescent Psychiatry University Hospital Essen University of Duisburg Essen Essen Germany

Department of Child and Adolescent Psychiatry University of Münster Münster Germany

Department of Clinical Medicine Laboratory Building Haukeland University Hospital Bergen Norway

Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden

Department of Clinical Nutrition Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland

Department of Clinical Science Norwegian Centre for Mental Disorders Research University of Bergen Bergen Norway

Department of Clinical Sciences School of Medicine University of Barcelona Barcelona Spain

Department of Emergency Psychiatry and Post Acute Care CHRU Montpellier University of Montpellier Montpellier France

Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Lodz Poland

Department of Epidemiology Harvard T H Chan School of Public Health Harvard University Cambridge Massachusetts USA

Department of Epidemiology School of Public Health Boston University Boston Massachusetts USA

Department of General Internal Medicine and Psychosomatics Heidelberg University Hospital Heidelberg University Heidelberg Germany

Department of General Practice and Primary Health Care University of Helsinki Helsinki Finland

Department of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Medical Faculty Mannheim Heidelberg University Mannheim Germany

Department of Genetics and Genomic Biology The Hospital for Sick Children Toronto Ontario Canada

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Department of Genetics University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

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Department of Medical and Molecular Genetics King's College London Guy's Hospital London UK

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Division of Child and Adolescent Psychiatry Geneva University Hospital Geneva Switzerland

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Division of Psychological and Social Medicine and Developmental Neurosciences Faculty of Medicine Technische Universität Dresden Dresden Germany

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Eating Disorders Unit Department of Child and Adolescent Psychiatry Medical University of Vienna Vienna Austria

Eating Disorders Unit Parklandklinik Bad Wildungen Germany

Eating Recovery Center Denver Colorado USA

Eist Linn Adolescent Unit Bessborough Health Service Executive South Cork Ireland

Estonian Genome Center University of Tartu Tartu Estonia

Faculty of Business Karabuk University Karabuk Turkey

Faculty of Health Sciences Palacky University Olomouc Czech Republic

Faculty of Social and Behavioral Sciences Utrecht University Utrecht The Netherlands

Fellow Program RTI International Research Triangle Park North Carolina USA

Genomics and Disease Bioinformatics and Genomics Programme Centre for Genomic Regulation Barcelona Spain

Groningen Institute for Evolutionary Life Sciences University of Groningen Groningen The Netherlands

Human Genomics Research Group Department of Biomedicine University of Basel Basel Switzerland

Institute for Behavioral Genetics University of Colorado Boulder Boulder Colorado USA

Institute for Genomic Medicine University of California San Diego La Jolla California USA

Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia

Institute for Molecular Medicine FIMM HiLIFE University of Helsinki Helsinki Finland

Institute of Applied Health Sciences School of Medicine Medical Sciences and Nutrition University of Aberdeen Aberdeen UK

Institute of Behavioral Science University of Colorado Boulder Colorado USA

Institute of Biomedicine University of Barcelona Barcelona Spain

Institute of Clinical Medicine University of Oslo Oslo Norway

Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

Institute of Human Genetics School of Medicine and University Hospital Bonn University of Bonn Bonn Germany

Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany

Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland

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Institute of Psychiatry and Neuroscience of Paris INSERM U1266 Paris France

Institute of Translational Genomics Helmholtz Zentrum München German Research Centre for Environmental Health Neuherberg Germany

IRCCS Fondazione Don Carlo Gnocchi Florence Italy

J Craig Venter Institute La Jolla California USA

Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

Kartini Clinic Portland Oregon USA

Klinikum Frankfurt Oder Frankfurt Germany

l'institut du thorax INSERM CNRS Univ Nantes Nantes France

Laboratory of Neurogenetics NIH NIAAA Bethesda Maryland USA

Max Planck Institute of Psychiatry Munich Germany

McLaughlin Centre University of Toronto Toronto Ontario Canada

Medical Park Chiemseeblick in Bernau Felden Ludwig Maximilians University Bernau am Chiemsee Germany

Michael G DeGroote Centre for Medicinal Cannabis Research McMaster University St Joseph's Healthcare Hamilton Hamilton Ontario Canada

Molecular Epidemiology Section Leiden University Medical Centre Leiden The Netherlands

MRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK

MRC Integrative Epidemiology Unit University of Bristol Bristol UK

National Center for PTSD VA Boston Healthcare System Boston Massachusetts USA

National Centre for Register Based Research Aarhus BSS Aarhus University Aarhus Denmark

National Drug and Alcohol Research Centre University of New South Wales Sydney New South Wales Australia

National Institute for Health and Welfare Helsinki Finland

National Institute for Health Research Biomedical Research Centre King's College London and South London and Maudsley National Health Service Trust London UK

NIAAA Intramural Research Program Bethesda Maryland USA

NORMENT Centre Division of Mental Health and Addiction NORMENT Centre University of Oslo Oslo University Hospital Oslo Norway

NORMENT KG Jebsen Centre Division of Mental Health and Addiction University of Oslo Oslo University Hospital Oslo Norway

Office of the Clinical Director NIH NIAAA Besthesda Maryland USA

Office of the Clinical Director NIH NIAAA Bethesda Maryland USA

Oregon Research Institute Eugene Oregon USA

Pediatric Intensive Care Unit P and A Kyriakou Children's Hospital University of Athens Athens Greece

Peter Boris Centre for Addictions Research McMaster University St Joseph's Healthcare Hamilton Hamilton Ontario Canada

Population Health Department QIMR Berghofer Medical Research Institute Brisbane Queensland Australia

Program for Eating Disorders University Health Network Toronto Ontario Canada

Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge Massachusetts USA

Psychiatric Genomics and Pharmacogenomics Program Mayo Clinic Rochester Minnesota USA

Psychiatric Hospital Ludwig Maximilians University Bernau am Chiemsee Germany

QIMR Berghofer Medical Research Institute Brisbane Queensland Australia

Queensland Brain Institute University of Queensland Brisbane Queensland Australia

Rheumatology Research Group Vall d'Hebron Research Institute Barcelona Spain

Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Saint Joan de Déu Research Institute Saint Joan de Déu Barcelona Children's Hospital Barcelona Spain

Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich Munich Germany

School of Paediatrics and Child Health University of Western Australia Perth Western Australia Australia

School of Pharmacy University of Pittsburgh Pittsburgh Pennsylvania USA

School of Psychology Curtin University Perth Western Australia Australia

School of Psychology Flinders University Adelaide South Australia Australia

School of Social and Community Medicine University of Bristol Bristol UK

Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology and Neuroscience King's College London London UK

Stanford University Graduate School of Education Stanford University Stanford California USA

Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts USA

The Center for Eating Disorders at Sheppard Pratt Baltimore Maryland USA

The Chicago School of Professional Psychology Washington DC Campus Washington District of Columbia USA

The Lundbeck Foundation Initiative for Integrative Psychiatric Research Aarhus Denmark

Turku Institute for Advanced Studies University of Turku Turku Finland

Universitat Pompeu Fabra Barcelona Spain

Veterans Affairs Connecticut Healthcare System West Haven Connecticut USA

Virginia Commonwealth University Alcohol Research Center Virginia Commonwealth University Richmond Virginia USA

Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Richmond Virginia USA

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Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge UK

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$a Munn-Chernoff, Melissa A $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
245    10
$a Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies / $c MA. Munn-Chernoff, EC. Johnson, YL. Chou, JRI. Coleman, LM. Thornton, RK. Walters, Z. Yilmaz, JH. Baker, C. Hübel, S. Gordon, SE. Medland, HJ. Watson, HA. Gaspar, J. Bryois, A. Hinney, VM. Leppä, M. Mattheisen, S. Ripke, S. Yao, P. Giusti-Rodríguez, KB. Hanscombe, RAH. Adan, L. Alfredsson, T. Ando, OA. Andreassen, WH. Berrettini, I. Boehm, C. Boni, V. Boraska Perica, K. Buehren, R. Burghardt, M. Cassina, S. Cichon, M. Clementi, RD. Cone, P. Courtet, S. Crow, JJ. Crowley, UN. Danner, OSP. Davis, M. de Zwaan, G. Dedoussis, D. Degortes, JE. DeSocio, DM. Dick, D. Dikeos, C. Dina, M. Dmitrzak-Weglarz, E. Docampo, LE. Duncan, K. Egberts, S. Ehrlich, G. Escaramís, T. Esko, X. Estivill, A. Farmer, A. Favaro, F. Fernández-Aranda, MM. Fichter, K. Fischer, M. Föcker, L. Foretova, AJ. Forstner, M. Forzan, CS. Franklin, S. Gallinger, I. Giegling, J. Giuranna, F. Gonidakis, P. Gorwood, M. Gratacos Mayora, S. Guillaume, Y. Guo, H. Hakonarson, K. Hatzikotoulas, J. Hauser, J. Hebebrand, SG. Helder, S. Herms, B. Herpertz-Dahlmann, W. Herzog, LM. Huckins, JI. Hudson, H. Imgart, H. Inoko, V. Janout, S. Jiménez-Murcia, A. Julià, G. Kalsi, D. Kaminská, L. Karhunen, A. Karwautz, MJH. Kas, JL. Kennedy, A. Keski-Rahkonen, K. Kiezebrink, YR. Kim, KL. Klump, GPS. Knudsen, MC. La Via, S. Le Hellard, RD. Levitan, D. Li, L. Lilenfeld, BD. Lin, J. Lissowska, J. Luykx, PJ. Magistretti, M. Maj, K. Mannik, S. Marsal, CR. Marshall, M. Mattingsdal, S. McDevitt, P. McGuffin, A. Metspalu, I. Meulenbelt, N. Micali, K. Mitchell, AM. Monteleone, P. Monteleone, B. Nacmias, M. Navratilova, I. Ntalla, JK. O'Toole, RA. Ophoff, L. Padyukov, A. Palotie, J. Pantel, H. Papezova, D. Pinto, R. Rabionet, A. Raevuori, N. Ramoz, T. Reichborn-Kjennerud, V. Ricca, S. Ripatti, F. Ritschel, M. Roberts, A. Rotondo, D. Rujescu, F. Rybakowski, P. Santonastaso, A. Scherag, SW. Scherer, U. Schmidt, NJ. Schork, A. Schosser, J. Seitz, L. Slachtova, PE. Slagboom, MCT. Slof-Op't Landt, A. Slopien, S. Sorbi, B. Świątkowska, JP. Szatkiewicz, I. Tachmazidou, E. Tenconi, A. Tortorella, F. Tozzi, J. Treasure, A. Tsitsika, M. Tyszkiewicz-Nwafor, K. Tziouvas, AA. van Elburg, EF. van Furth, G. Wagner, E. Walton, E. Widen, E. Zeggini, S. Zerwas, S. Zipfel, AW. Bergen, JM. Boden, H. Brandt, S. Crawford, KA. Halmi, LJ. Horwood, C. Johnson, AS. Kaplan, WH. Kaye, J. Mitchell, CM. Olsen, JF. Pearson, NL. Pedersen, M. Strober, T. Werge, DC. Whiteman, DB. Woodside, J. Grove, AK. Henders, JT. Larsen, R. Parker, LV. Petersen, J. Jordan, MA. Kennedy, A. Birgegård, P. Lichtenstein, C. Norring, M. Landén, PB. Mortensen, R. Polimanti, JN. McClintick, AE. Adkins, F. Aliev, SA. Bacanu, A. Batzler, S. Bertelsen, JM. Biernacka, TB. Bigdeli, LS. Chen, TK. Clarke, F. Degenhardt, AR. Docherty, AC. Edwards, JC. Foo, L. Fox, J. Frank, LM. Hack, AM. Hartmann, SM. Hartz, S. Heilmann-Heimbach, C. Hodgkinson, P. Hoffmann, JJ. Hottenga, B. Konte, J. Lahti, M. Lahti-Pulkkinen, D. Lai, L. Ligthart, A. Loukola, BS. Maher, H. Mbarek, AM. McIntosh, MB. McQueen, JL. Meyers, Y. Milaneschi, T. Palviainen, RE. Peterson, E. Ryu, NL. Saccone, JE. Salvatore, S. Sanchez-Roige, M. Schwandt, R. Sherva, F. Streit, J. Strohmaier, N. Thomas, JC. Wang, BT. Webb, R. Wedow, L. Wetherill, AG. Wills, H. Zhou, JD. Boardman, D. Chen, DS. Choi, WE. Copeland, RC. Culverhouse, N. Dahmen, L. Degenhardt, BW. Domingue, MA. Frye, W. Gäebel, C. Hayward, M. Ising, M. Keyes, F. Kiefer, G. Koller, J. Kramer, S. Kuperman, S. Lucae, MT. Lynskey, W. Maier, K. Mann, S. Männistö, B. Müller-Myhsok, AD. Murray, JI. Nurnberger, U. Preuss, K. Räikkönen, MD. Reynolds, M. Ridinger, N. Scherbaum, MA. Schuckit, M. Soyka, J. Treutlein, SH. Witt, N. Wodarz, P. Zill, DE. Adkins, DI. Boomsma, LJ. Bierut, SA. Brown, KK. Bucholz, EJ. Costello, H. de Wit, N. Diazgranados, JG. Eriksson, LA. Farrer, TM. Foroud, NA. Gillespie, AM. Goate, D. Goldman, RA. Grucza, DB. Hancock, KM. Harris, V. Hesselbrock, JK. Hewitt, CJ. Hopfer, WG. Iacono, EO. Johnson, VM. Karpyak, KS. Kendler, HR. Kranzler, K. Krauter, PA. Lind, M. McGue, J. MacKillop, PAF. Madden, HH. Maes, PKE. Magnusson, EC. Nelson, MM. Nöthen, AA. Palmer, BWJH. Penninx, B. Porjesz, JP. Rice, M. Rietschel, BP. Riley, RJ. Rose, PH. Shen, J. Silberg, MC. Stallings, RE. Tarter, MM. Vanyukov, S. Vrieze, TL. Wall, JB. Whitfield, H. Zhao, BM. Neale, TD. Wade, AC. Heath, GW. Montgomery, NG. Martin, PF. Sullivan, J. Kaprio, G. Breen, J. Gelernter, HJ. Edenberg, CM. Bulik, A. Agrawal
520    9_
$a Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
650    _2
$a alkoholismus $x genetika $7 D000437
650    _2
$a depresivní porucha unipolární $x genetika $7 D003865
650    _2
$a poruchy příjmu potravy $x genetika $7 D001068
650    _2
$a celogenomová asociační studie $7 D055106
650    _2
$a lidé $7 D006801
650    _2
$a vazebná nerovnováha $7 D015810
650    _2
$a fenotyp $7 D010641
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a rizikové faktory $7 D012307
650    _2
$a schizofrenie $x genetika $7 D012559
650    _2
$a poruchy spojené s užíváním psychoaktivních látek $x genetika $7 D019966
650    _2
$a poruchy vyvolané užíváním tabáku $x genetika $7 D014029
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
700    1_
$a Johnson, Emma C $u Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Chou, Yi-Ling $u Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Coleman, Jonathan R I $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK $u National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Trust, London, UK
700    1_
$a Thornton, Laura M $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Walters, Raymond K $u Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
700    1_
$a Yilmaz, Zeynep $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA $u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Baker, Jessica H $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Hübel, Christopher $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK $u National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Trust, London, UK $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Gordon, Scott $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
700    1_
$a Medland, Sarah E $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
700    1_
$a Watson, Hunna J $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA $u School of Psychology, Curtin University, Perth, Western Australia, Australia $u School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
700    1_
$a Gaspar, Héléna A $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK $u National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Trust, London, UK
700    1_
$a Bryois, Julien $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Hinney, Anke $u Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
700    1_
$a Leppä, Virpi M $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Mattheisen, Manuel $u Department of Biomedicine, Aarhus University, Aarhus, Denmark $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden $u Center for Psychiatry Research, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden $u Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Germany
700    1_
$a Ripke, Stephan $u Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA $u Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany
700    1_
$a Yao, Shuyang $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Giusti-Rodríguez, Paola $u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Hanscombe, Ken B $u Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK
700    1_
$a Adan, Roger A H $u Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands $u Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands $u Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
700    1_
$a Alfredsson, Lars $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Ando, Tetsuya $u Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
700    1_
$a Andreassen, Ole A $u NORMENT Centre, Division of Mental Health and Addiction, NORMENT Centre, University of Oslo, Oslo University Hospital, Oslo, Norway
700    1_
$a Berrettini, Wade H $u Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
700    1_
$a Boehm, Ilka $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
700    1_
$a Boni, Claudette $u Centre of Psychiatry and Neuroscience, INSERM U894, Paris, France
700    1_
$a Boraska Perica, Vesna $u Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK $u Department of Medical Biology, School of Medicine, University of Split, Split, Croatia
700    1_
$a Buehren, Katharina $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
700    1_
$a Burghardt, Roland $u Klinikum Frankfurt/Oder, Frankfurt, Germany
700    1_
$a Cassina, Matteo $u Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Italy
700    1_
$a Cichon, Sven $u Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland $u Department of Biomedicine, University of Basel, Basel, Switzerland $u Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Germany
700    1_
$a Clementi, Maurizio $u Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Italy
700    1_
$a Cone, Roger D $u Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA
700    1_
$a Courtet, Philippe $u Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France
700    1_
$a Crow, Scott $u Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA
700    1_
$a Crowley, James J $u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Danner, Unna N $u Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands
700    1_
$a Davis, Oliver S P $u MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK $u School of Social and Community Medicine, University of Bristol, Bristol, UK
700    1_
$a de Zwaan, Martina $u Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany
700    1_
$a Dedoussis, George $u Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
700    1_
$a Degortes, Daniela $u Department of Neurosciences, University of Padova, Padova, Italy
700    1_
$a DeSocio, Janiece E $u College of Nursing, Seattle University, Seattle, Washington, USA
700    1_
$a Dick, Danielle M $u Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA $u College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA $u Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Dikeos, Dimitris $u Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece
700    1_
$a Dina, Christian $u l'institut du thorax, INSERM, CNRS, Univ Nantes, Nantes, France
700    1_
$a Dmitrzak-Weglarz, Monika $u Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
700    1_
$a Docampo, Elisa $u Barcelona Institute of Science and Technology, Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $u Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
700    1_
$a Duncan, Laramie E $u Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
700    1_
$a Egberts, Karin $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Würzburg, Würzburg, Germany
700    1_
$a Ehrlich, Stefan $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
700    1_
$a Escaramís, Geòrgia $u Barcelona Institute of Science and Technology, Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $u Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
700    1_
$a Esko, Tõnu $u Estonian Genome Center, University of Tartu, Tartu, Estonia $u Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
700    1_
$a Estivill, Xavier $u Barcelona Institute of Science and Technology, Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $u Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain $u Genomics and Disease, Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Barcelona, Spain
700    1_
$a Farmer, Anne $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
700    1_
$a Favaro, Angela $u Department of Neurosciences, University of Padova, Padova, Italy
700    1_
$a Fernández-Aranda, Fernando $u Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain $u Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
700    1_
$a Fichter, Manfred M $u Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany $u Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich, Munich, Germany
700    1_
$a Fischer, Krista $u Estonian Genome Center, University of Tartu, Tartu, Estonia
700    1_
$a Föcker, Manuel $u Department of Child and Adolescent Psychiatry, University of Münster, Münster, Germany
700    1_
$a Foretova, Lenka $u Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
700    1_
$a Forstner, Andreas J $u Department of Biomedicine, University of Basel, Basel, Switzerland $u Centre for Human Genetics, University of Marburg, Marburg, Germany $u Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany $u Department of Psychiatry (UPK), University of Basel, Basel, Switzerland
700    1_
$a Forzan, Monica $u Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Italy
700    1_
$a Franklin, Christopher S $u Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
700    1_
$a Gallinger, Steven $u Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
700    1_
$a Giegling, Ina $u Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
700    1_
$a Giuranna, Johanna $u Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
700    1_
$a Gonidakis, Fragiskos $u 1st Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece
700    1_
$a Gorwood, Philip $u Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France $u CMME (GHU Paris Psychiatrie et Neurosciences), Paris Descartes University, Paris, France
700    1_
$a Gratacos Mayora, Monica $u Barcelona Institute of Science and Technology, Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $u Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
700    1_
$a Guillaume, Sébastien $u Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France
700    1_
$a Guo, Yiran $u Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
700    1_
$a Hakonarson, Hakon $u Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA $u Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
700    1_
$a Hatzikotoulas, Konstantinos $u Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK $u Institute of Translational Genomics, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany
700    1_
$a Hauser, Joanna $u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
700    1_
$a Hebebrand, Johannes $u Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
700    1_
$a Helder, Sietske G $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK $u Zorg op Orde, Delft, The Netherlands
700    1_
$a Herms, Stefan $u Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland $u Department of Biomedicine, University of Basel, Basel, Switzerland
700    1_
$a Herpertz-Dahlmann, Beate $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
700    1_
$a Herzog, Wolfgang $u Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany
700    1_
$a Huckins, Laura M $u Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK $u Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
700    1_
$a Hudson, James I $u Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, Massachusetts, USA
700    1_
$a Imgart, Hartmut $u Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany
700    1_
$a Inoko, Hidetoshi $u Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan
700    1_
$a Janout, Vladimir $u Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic
700    1_
$a Jiménez-Murcia, Susana $u Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain $u Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain
700    1_
$a Julià, Antonio $u Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain
700    1_
$a Kalsi, Gursharan $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
700    1_
$a Kaminská, Deborah $u Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Karhunen, Leila $u Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
700    1_
$a Karwautz, Andreas $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
700    1_
$a Kas, Martien J H $u Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands $u Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
700    1_
$a Kennedy, James L $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada $u Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada $u Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
700    1_
$a Keski-Rahkonen, Anna $u Department of Public Health, University of Helsinki, Helsinki, Finland
700    1_
$a Kiezebrink, Kirsty $u Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK
700    1_
$a Kim, Youl-Ri $u Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea
700    1_
$a Klump, Kelly L $u Department of Psychology, Michigan State University, East Lansing, Michigan, USA
700    1_
$a Knudsen, Gun Peggy S $u Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a La Via, Maria C $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Le Hellard, Stephanie $u Department of Clinical Science, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway $u Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway $u Department of Clinical Medicine, Laboratory Building, Haukeland University Hospital, Bergen, Norway
700    1_
$a Levitan, Robert D $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada $u Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada $u Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
700    1_
$a Li, Dong $u Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
700    1_
$a Lilenfeld, Lisa $u The Chicago School of Professional Psychology, Washington DC Campus, Washington, District of Columbia, USA
700    1_
$a Lin, Bochao Danae $u Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
700    1_
$a Lissowska, Jolanta $u Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland
700    1_
$a Luykx, Jurjen $u Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
700    1_
$a Magistretti, Pierre J $u BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia $u Department of Psychiatry, University of Lausanne-University Hospital of Lausanne (UNIL-CHUV), Lausanne, Switzerland
700    1_
$a Maj, Mario $u Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy
700    1_
$a Mannik, Katrin $u Estonian Genome Center, University of Tartu, Tartu, Estonia $u Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
700    1_
$a Marsal, Sara $u Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain
700    1_
$a Marshall, Christian R $u Department of Paediatric Laboratory Medicine, Division of Genome Diagnostics, The Hospital for Sick Children, Toronto, Ontario, Canada
700    1_
$a Mattingsdal, Morten $u NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway
700    1_
$a McDevitt, Sara $u Department of Psychiatry, University College Cork, Cork, Ireland $u Eist Linn Adolescent Unit, Bessborough, Health Service Executive South, Cork, Ireland
700    1_
$a McGuffin, Peter $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
700    1_
$a Metspalu, Andres $u Estonian Genome Center, University of Tartu, Tartu, Estonia $u Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
700    1_
$a Meulenbelt, Ingrid $u Molecular Epidemiology Section (Department of Biomedical Datasciences), Leiden University Medical Centre, Leiden, The Netherlands
700    1_
$a Micali, Nadia $u Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland $u Division of Child and Adolescent Psychiatry, Geneva University Hospital, Geneva, Switzerland
700    1_
$a Mitchell, Karen $u National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts, USA $u Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
700    1_
$a Monteleone, Alessio Maria $u Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy
700    1_
$a Monteleone, Palmiero $u Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy
700    1_
$a Nacmias, Benedetta $u Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy
700    1_
$a Navratilova, Marie $u Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
700    1_
$a Ntalla, Ioanna $u Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
700    1_
$a O'Toole, Julie K $u Kartini Clinic, Portland, Oregon, USA
700    1_
$a Ophoff, Roel A $u Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA $u Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
700    1_
$a Padyukov, Leonid $u Department of Medicine, Center for Molecular Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
700    1_
$a Palotie, Aarno $u Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA $u Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland $u Center for Human Genome Research, Massachusetts General Hospital, Boston, Massachusetts, USA
700    1_
$a Pantel, Jacques $u Centre of Psychiatry and Neuroscience, INSERM U894, Paris, France
700    1_
$a Papezova, Hana $u Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Pinto, Dalila $u Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA
700    1_
$a Rabionet, Raquel $u Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children's Hospital, Barcelona, Spain $u Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain $u Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain
700    1_
$a Raevuori, Anu $u Department of Public Health, University of Helsinki, Helsinki, Finland
700    1_
$a Ramoz, Nicolas $u Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France
700    1_
$a Reichborn-Kjennerud, Ted $u Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway
700    1_
$a Ricca, Valdo $u Department of Health Science, University of Florence, Florence, Italy
700    1_
$a Ripatti, Samuli $u Department of Biometry, University of Helsinki, Helsinki, Finland
700    1_
$a Ritschel, Franziska $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany $u Department of Child and Adolescent Psychiatry, Faculty of Medicine, Eating Disorders Research and Treatment Center, Technische Universität Dresden, Dresden, Germany
700    1_
$a Roberts, Marion $u Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
700    1_
$a Rotondo, Alessandro $u Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy
700    1_
$a Rujescu, Dan $u Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
700    1_
$a Rybakowski, Filip $u Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
700    1_
$a Santonastaso, Paolo $u Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy
700    1_
$a Scherag, André $u Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany
700    1_
$a Scherer, Stephen W $u Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada $u McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada
700    1_
$a Schmidt, Ulrike $u Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
700    1_
$a Schork, Nicholas J $u J. Craig Venter Institute (JCVI), La Jolla, California, USA
700    1_
$a Schosser, Alexandra $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
700    1_
$a Seitz, Jochen $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
700    1_
$a Slachtova, Lenka $u Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Slagboom, P Eline $u Molecular Epidemiology Section (Department of Medical Statistics), Leiden University Medical Centre, Leiden, The Netherlands
700    1_
$a Slof-Op't Landt, Margarita C T $u Center for Eating Disorders Ursula, Rivierduinen, Leiden, The Netherlands $u Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
700    1_
$a Slopien, Agnieszka $u Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
700    1_
$a Sorbi, Sandro $u Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy $u IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy
700    1_
$a Świątkowska, Beata $u Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
700    1_
$a Szatkiewicz, Jin P $u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Tachmazidou, Ioanna $u Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
700    1_
$a Tenconi, Elena $u Department of Neurosciences, University of Padova, Padova, Italy
700    1_
$a Tortorella, Alfonso $u Department of Psychiatry, University of Naples SUN, Naples, Italy $u Department of Psychiatry, University of Perugia, Perugia, Italy
700    1_
$a Tozzi, Federica $u Brain Sciences Department, Stremble Ventures, Limassol, Cyprus
700    1_
$a Treasure, Janet $u Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
700    1_
$a Tsitsika, Artemis $u Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece
700    1_
$a Tyszkiewicz-Nwafor, Marta $u Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
700    1_
$a Tziouvas, Konstantinos $u Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece
700    1_
$a van Elburg, Annemarie A $u Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands $u Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, The Netherlands
700    1_
$a van Furth, Eric F $u Center for Eating Disorders Ursula, Rivierduinen, Leiden, The Netherlands $u Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
700    1_
$a Wagner, Gudrun $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
700    1_
$a Walton, Esther $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
700    1_
$a Widen, Elisabeth $u Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
700    1_
$a Zeggini, Eleftheria $u Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK $u Institute of Translational Genomics, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany
700    1_
$a Zerwas, Stephanie $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
700    1_
$a Zipfel, Stephan $u Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany
700    1_
$a Bergen, Andrew W $u BioRealm, LLC, Walnut, California, USA $u Oregon Research Institute, Eugene, Oregon, USA
700    1_
$a Boden, Joseph M $u Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand
700    1_
$a Brandt, Harry $u The Center for Eating Disorders at Sheppard Pratt, Baltimore, Maryland, USA
700    1_
$a Crawford, Steven $u The Center for Eating Disorders at Sheppard Pratt, Baltimore, Maryland, USA
700    1_
$a Halmi, Katherine A $u Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA
700    1_
$a Horwood, L John $u Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand
700    1_
$a Johnson, Craig $u Eating Recovery Center, Denver, Colorado, USA
700    1_
$a Kaplan, Allan S $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada $u Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada $u Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
700    1_
$a Kaye, Walter H $u Department of Psychiatry, University of California San Diego, La Jolla, California, USA
700    1_
$a Mitchell, James $u Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA
700    1_
$a Olsen, Catherine M $u Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
700    1_
$a Pearson, John F $u Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand
700    1_
$a Pedersen, Nancy L $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Strober, Michael $u Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA $u David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
700    1_
$a Werge, Thomas $u Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
700    1_
$a Whiteman, David C $u Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
700    1_
$a Woodside, D Blake $u Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada $u Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada $u Centre for Mental Health, University Health Network, Toronto, Ontario, Canada $u Program for Eating Disorders, University Health Network, Toronto, Ontario, Canada
700    1_
$a Grove, Jakob $u Department of Biomedicine, Aarhus University, Aarhus, Denmark $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark $u Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark $u Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
700    1_
$a Henders, Anjali K $u Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
700    1_
$a Larsen, Janne T $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark $u National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark $u Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark
700    1_
$a Parker, Richard $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
700    1_
$a Petersen, Liselotte V $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark $u National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark $u Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark
700    1_
$a Jordan, Jennifer $u Department of Psychological Medicine, University of Otago, Christchurch, New Zealand $u Canterbury District Health Board, Christchurch, New Zealand
700    1_
$a Kennedy, Martin A $u Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand
700    1_
$a Birgegård, Andreas $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden $u Center for Psychiatry Research, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden
700    1_
$a Lichtenstein, Paul $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Norring, Claes $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden $u Center for Psychiatry Research, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden
700    1_
$a Landén, Mikael $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden $u Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
700    1_
$a Mortensen, Preben Bo $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark $u National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark $u Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark
700    1_
$a Polimanti, Renato $u Department of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, Connecticut, USA $u Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
700    1_
$a McClintick, Jeanette N $u Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
700    1_
$a Adkins, Amy E $u Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA $u College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Aliev, Fazil $u Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA $u Faculty of Business, Karabuk University, Karabuk, Turkey
700    1_
$a Bacanu, Silviu-Alin $u Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA $u Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA $u Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Batzler, Anthony $u Psychiatric Genomics and Pharmacogenomics Program, Mayo Clinic, Rochester, Minnesota, USA
700    1_
$a Bertelsen, Sarah $u Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA
700    1_
$a Biernacka, Joanna M $u Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA $u Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA
700    1_
$a Bigdeli, Tim B $u Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA
700    1_
$a Chen, Li-Shiun $u Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Clarke, Toni-Kim $u Division of Psychiatry, University of Edinburgh, Edinburgh, UK
700    1_
$a Degenhardt, Franziska $u Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
700    1_
$a Docherty, Anna R $u Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA
700    1_
$a Edwards, Alexis C $u Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA $u Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Foo, Jerome C $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
700    1_
$a Fox, Louis $u Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Frank, Josef $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
700    1_
$a Hack, Laura M $u Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
700    1_
$a Hartmann, Annette M $u Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
700    1_
$a Hartz, Sarah M $u Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Heilmann-Heimbach, Stefanie $u Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany
700    1_
$a Hodgkinson, Colin $u Laboratory of Neurogenetics, NIH/NIAAA, Bethesda, Maryland, USA
700    1_
$a Hoffmann, Per $u Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland $u Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany $u Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
700    1_
$a Hottenga, Jouke-Jan $u Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
700    1_
$a Konte, Bettina $u Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
700    1_
$a Lahti, Jari $u Turku Institute for Advanced Studies, University of Turku, Turku, Finland
700    1_
$a Lahti-Pulkkinen, Marius $u Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
700    1_
$a Lai, Dongbing $u Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
700    1_
$a Ligthart, Lannie $u Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
700    1_
$a Loukola, Anu $u Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
700    1_
$a Maher, Brion S $u Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
700    1_
$a Mbarek, Hamdi $u Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
700    1_
$a McIntosh, Andrew M $u Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
700    1_
$a McQueen, Matthew B $u Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA
700    1_
$a Meyers, Jacquelyn L $u Department of Psychiatry and Behavioral Sciences, Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, New York, USA
700    1_
$a Milaneschi, Yuri $u Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands
700    1_
$a Palviainen, Teemu $u Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland
700    1_
$a Peterson, Roseann E $u Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA $u Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Ryu, Euijung $u Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
700    1_
$a Saccone, Nancy L $u Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Salvatore, Jessica E $u Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA $u Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA $u Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Sanchez-Roige, Sandra $u Department of Psychiatry, University of California San Diego, La Jolla, California, USA
700    1_
$a Schwandt, Melanie $u Office of the Clinical Director, NIH/NIAAA, Bethesda, Maryland, USA
700    1_
$a Sherva, Richard $u Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA
700    1_
$a Streit, Fabian $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
700    1_
$a Strohmaier, Jana $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
700    1_
$a Thomas, Nathaniel $u Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA $u College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Wang, Jen-Chyong $u Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA
700    1_
$a Webb, Bradley T $u Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA $u Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA $u Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
700    1_
$a Wedow, Robbee $u Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, Massachusetts, USA $u Department of Sociology, Harvard University, Cambridge, Massachusetts, USA
700    1_
$a Wetherill, Leah $u Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
700    1_
$a Wills, Amanda G $u Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA
700    1_
$a Zhou, Hang $u Department of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, Connecticut, USA $u Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
700    1_
$a Boardman, Jason D $u Institute of Behavioral Science, University of Colorado, Boulder, Colorado, USA $u Department of Sociology, University of Colorado, Boulder, Colorado, USA
700    1_
$a Chen, Danfeng $u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
700    1_
$a Choi, Doo-Sup $u Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
700    1_
$a Copeland, William E $u Department of Psychiatry, University of Vermont Medical Center, Burlington, Vermont, USA
700    1_
$a Culverhouse, Robert C $u Department of Medicine, Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri, USA
700    1_
$a Dahmen, Norbert $u Department of Psychiatry, University of Mainz, Mainz, Germany
700    1_
$a Degenhardt, Louisa $u National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia
700    1_
$a Domingue, Benjamin W $u Stanford University Graduate School of Education, Stanford University, Stanford, California, USA
700    1_
$a Frye, Mark A $u Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA
700    1_
$a Gäebel, Wolfgang $u Department of Psychiatry and Psychotherapy, University of Düsseldorf, Duesseldorf, Germany
700    1_
$a Hayward, Caroline $u MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
700    1_
$a Ising, Marcus $u Max-Planck-Institute of Psychiatry, Munich, Germany
700    1_
$a Keyes, Margaret $u Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
700    1_
$a Kiefer, Falk $u Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
700    1_
$a Koller, Gabriele $u Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
700    1_
$a Kramer, John $u Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
700    1_
$a Kuperman, Samuel $u Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
700    1_
$a Lucae, Susanne $u Max-Planck-Institute of Psychiatry, Munich, Germany
700    1_
$a Lynskey, Michael T $u Addictions Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
700    1_
$a Maier, Wolfgang $u Department of Psychiatry, University of Bonn, Bonn, Germany
700    1_
$a Mann, Karl $u Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
700    1_
$a Männistö, Satu $u Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
700    1_
$a Müller-Myhsok, Bertram $u Department of Statistical Genetics, Max-Planck-Institute of Psychiatry, München, Germany
700    1_
$a Murray, Alison D $u Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill, Aberdeen, UK
700    1_
$a Nurnberger, John I $u Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA $u Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
700    1_
$a Preuss, Ulrich $u Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Herborn, Germany $u Department of Psychiatry and Psychotherapy, Vitos Hospital Herborn, Herborn, Germany
700    1_
$a Räikkönen, Katri $u Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
700    1_
$a Reynolds, Maureen D $u School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
700    1_
$a Ridinger, Monika $u Department of Psychiatry and Psychotherapy, University of Regensburg Psychiatric Health Care Aargau, Regensburg, Germany
700    1_
$a Scherbaum, Norbert $u Department of Psychiatry and Psychotherapy and Department of Addictive Behaviour and Addiction Medicine, Medical Faculty, LVR-Hospital Essen, University of Duisburg-Essen, Essen, Germany
700    1_
$a Schuckit, Marc A $u Department of Psychiatry, University of California San Diego, La Jolla, California, USA
700    1_
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