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Mild and Selective Method of Bromination of Flavonoids
M. Hurtová, D. Biedermann, M. Kuzma, V. Křen
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Flavonoids chemistry MeSH
- Halogenation * MeSH
- Spectrometry, Mass, Electrospray Ionization methods MeSH
- Molecular Structure MeSH
- Oxidation-Reduction MeSH
- Silymarin chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
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- $a A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
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