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Multiple occurrence of premature polyarticular osteoarthritis in an early medieval Bohemian cemetery (Prague, Czech Republic)

S. Drtikolová Kaupová, P. Velemínský, J. Cvrček, V. Džupa, V. Kuželka, M. Laboš, A. Němečková, K. Tomková, E. Zazvonilová, S. Kacki

. 2020 ; 30 (-) : 35-46. [pub] 20200514

Jazyk angličtina Země Nizozemsko

Typ dokumentu historické články, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004855

OBJECTIVES: To highlight conditions that may cause early-onset degenerative joint disease, and to assess the possible impact of such diseases upon everyday life. MATERIAL: Four adults aged under 50 years from a medieval skeletal collection of Prague (Czechia). METHODS: Visual, osteometric, X-ray, and histological examinations, stable isotope analysis of bone collagen. RESULTS: All four individuals showed multiple symmetrical degenerative changes, affecting the majority of joints of the postcranial skeleton. Associated dysplastic deformities were observed in all individuals, including bilateral hip dysplasia (n = 1), flattening of the femoral condyles (n = 3), and substantial deformation of the elbows (n = 3). The diet of the affected individuals differed from the contemporary population sample. CONCLUSIONS: We propose the diagnosis of a mild form of skeletal dysplasia in these four individuals, with multiple epiphyseal dysplasia or type-II collagenopathy linked to premature osteoarthritis as the most probable causes. SIGNIFICANCE: Combining the skeletal findings with information from the medical literature, this paper defines several characteristic traits which may assist with the diagnosis of skeletal dysplasia in the archaeological record. LIMITATIONS: As no genetic analysis was performed to confirm the possible kinship of the individuals, it is not possible to definitively assess whether the individuals suffered from the same hereditary condition or from different forms of skeletal dysplasia. SUGGESTIONS FOR FURTHER RESEARCH: Further studies on premature osteoarthritis in archaeological skeletal series are needed to correct the underrepresentation of these mild forms of dysplasia in past populations.

Citace poskytuje Crossref.org

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$a Multiple occurrence of premature polyarticular osteoarthritis in an early medieval Bohemian cemetery (Prague, Czech Republic) / $c S. Drtikolová Kaupová, P. Velemínský, J. Cvrček, V. Džupa, V. Kuželka, M. Laboš, A. Němečková, K. Tomková, E. Zazvonilová, S. Kacki
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$a OBJECTIVES: To highlight conditions that may cause early-onset degenerative joint disease, and to assess the possible impact of such diseases upon everyday life. MATERIAL: Four adults aged under 50 years from a medieval skeletal collection of Prague (Czechia). METHODS: Visual, osteometric, X-ray, and histological examinations, stable isotope analysis of bone collagen. RESULTS: All four individuals showed multiple symmetrical degenerative changes, affecting the majority of joints of the postcranial skeleton. Associated dysplastic deformities were observed in all individuals, including bilateral hip dysplasia (n = 1), flattening of the femoral condyles (n = 3), and substantial deformation of the elbows (n = 3). The diet of the affected individuals differed from the contemporary population sample. CONCLUSIONS: We propose the diagnosis of a mild form of skeletal dysplasia in these four individuals, with multiple epiphyseal dysplasia or type-II collagenopathy linked to premature osteoarthritis as the most probable causes. SIGNIFICANCE: Combining the skeletal findings with information from the medical literature, this paper defines several characteristic traits which may assist with the diagnosis of skeletal dysplasia in the archaeological record. LIMITATIONS: As no genetic analysis was performed to confirm the possible kinship of the individuals, it is not possible to definitively assess whether the individuals suffered from the same hereditary condition or from different forms of skeletal dysplasia. SUGGESTIONS FOR FURTHER RESEARCH: Further studies on premature osteoarthritis in archaeological skeletal series are needed to correct the underrepresentation of these mild forms of dysplasia in past populations.
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$a Velemínský, Petr $u Department of Anthropology, National Museum, Václavské Náměstí 68, 11579 Praha 1, Czech Republic. Electronic address: petr.veleminsky@nm.cz
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$a Cvrček, Jan $u Department of Anthropology, National Museum, Václavské Náměstí 68, 11579 Praha 1, Czech Republic; Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Viničná 7, 128 43, Praha 2, Czech Republic. Electronic address: jan.cvrcek@nm.cz
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$a Džupa, Valér $u Deparment of Orthopaedics and Traumatology, Third Faculty of Medicine, Charles University, and University Hospital Kralovske Vinohrady, Srobarova 50, 100 34, Praha 10, Czech Republic. Electronic address: valer.dzupa@fnkv.cz
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$a Kuželka, Vítězslav $u Department of Anthropology, National Museum, Václavské Náměstí 68, 11579 Praha 1, Czech Republic. Electronic address: vitezslav_kuzelka@nm.cz
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$a Laboš, Marek $u Deparment of Radiodiagnostics, Third Faculty of Medicine, Charles University, and University Hospital Kralovske Vinohrady, Srobarova 50, 100 34, Praha 10, Czech Republic. Electronic address: mareklabos@seznam.cz
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$a Němečková, Alena $u Department of Histology and Embryology, Medical Faculty in Pilsen, Charles University, Karlovarská 48, 301 00, Pilsen, Czech Republic. Electronic address: alena.nemeckova@lfp.cuni.cz
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$a Tomková, Kateřina $u Institute of Archaeology of the Czech Academy of Sciences, Prague, v.v.i., Letenská 4, 118 01 Praha 1, Czech Republic. Electronic address: tomkova@arup.cas.cz
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$a Zazvonilová, Eliška $u Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Viničná 7, 128 43, Praha 2, Czech Republic; Institute of Archaeology of the Czech Academy of Sciences, Prague, v.v.i., Letenská 4, 118 01 Praha 1, Czech Republic. Electronic address: zazvonilova@arup.cas.cz
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$a Kacki, Sacha $u CNRS, UMR 5199 PACEA, Université de Bordeaux, Bât. B8, Allée Geoffroy St Hilaire, CS 50023, 33615 Pessac Cedex, France; Department of Archaeology, Durham University, South Road, Durham, DH1 3LE, United Kingdom. Electronic address: sacha.kacki@u-bordeaux.fr
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