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Merging the exposome into an integrated framework for "omics" sciences

EJ. Price, CM. Vitale, GW. Miller, A. David, R. Barouki, K. Audouze, DI. Walker, JP. Antignac, X. Coumoul, V. Bessonneau, J. Klánová

. 2022 ; 25 (3) : 103976. [pub] 20220224

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22009933

The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual's health over their life course. However, disconnect between the concept and practical application has promoted divergent interpretations of the exposome across disciplines and reinforced separation of the environmental (emphasizing exposures) and biological (emphasizing responses) research communities. In particular, while knowledge of biological responses can help to distinguish actual (i.e. experienced) from potential exposures, the inclusion of endogenous processes has generated confusion about the position of the exposome in a multi-omics systems biology context. We propose a reattribution of "exposome" to exclusively represent the totality of contact with external factors that a biological entity experiences, and introduce the term "functional exposomics" to denote the systematic study of exposure-phenotype interaction. This reoriented definition of the exposome allows a more readily integrable dataset for multi-omics and systems biology research.

Citace poskytuje Crossref.org

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$a Barouki, Robert $u Université de Paris, T3S, Inserm UMR S-1124, Paris 75006, France $u Service de Biochimie Métabolomique et Protéomique, Hôpital Necker Enfants Malades, AP-HP, Paris, France
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