-
Something wrong with this record ?
Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter
K. Mareckova, R. Marecek, L. Andryskova, M. Brazdil, YS. Nikolova
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Amygdala diagnostic imaging pathology MeSH
- Depression * psychology MeSH
- Child MeSH
- Adult MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Magnetic Resonance Imaging methods MeSH
- Young Adult MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and Childhood prenatal birth cohort (n = 129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second halves of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. Depressive symptoms were measured via self-report using the Beck Depression Inventory. RESULTS: Exposure to stress during the first half of pregnancy was associated with smaller accessory basal (Cohen's f2 = 0.27, false discovery rate [FDR]-corrected p [pFDR] = .03) and cortical (Cohen's f2 = 0.29, pFDR = .03) nuclei volumes. This effect remained significant after correcting for sex, stress during the second half of pregnancy, maternal age at birth, birth weight, maternal education, and offspring's age at magnetic resonance imaging. These two nuclei showed a quadratic relationship with Beck Depression Inventory scores in young adulthood, where both smaller and larger volumes were associated with more depressive symptoms (accessory basal nucleus: adj. R2 = 0.05, pFDR = .015; cortical nucleus: adj. R2 = 0.04, pFDR = .015). CONCLUSIONS: We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood.
Department of Psychiatry University of Toronto Toronto Ontario Canada
RECETOX Faculty of Science Masaryk University Brno Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22011095
- 003
- CZ-PrNML
- 005
- 20230602102002.0
- 007
- ta
- 008
- 220425s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.bpsc.2021.07.009 $2 doi
- 035 __
- $a (PubMed)34358683
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Mareckova, Klara $u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Electronic address: klara.mareckova@ceitec.muni.cz
- 245 10
- $a Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter / $c K. Mareckova, R. Marecek, L. Andryskova, M. Brazdil, YS. Nikolova
- 520 9_
- $a BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and Childhood prenatal birth cohort (n = 129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second halves of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. Depressive symptoms were measured via self-report using the Beck Depression Inventory. RESULTS: Exposure to stress during the first half of pregnancy was associated with smaller accessory basal (Cohen's f2 = 0.27, false discovery rate [FDR]-corrected p [pFDR] = .03) and cortical (Cohen's f2 = 0.29, pFDR = .03) nuclei volumes. This effect remained significant after correcting for sex, stress during the second half of pregnancy, maternal age at birth, birth weight, maternal education, and offspring's age at magnetic resonance imaging. These two nuclei showed a quadratic relationship with Beck Depression Inventory scores in young adulthood, where both smaller and larger volumes were associated with more depressive symptoms (accessory basal nucleus: adj. R2 = 0.05, pFDR = .015; cortical nucleus: adj. R2 = 0.04, pFDR = .015). CONCLUSIONS: We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a amygdala $x diagnostické zobrazování $x patologie $7 D000679
- 650 _2
- $a dítě $7 D002648
- 650 12
- $a deprese $x psychologie $7 D003863
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a novorozenec $7 D007231
- 650 _2
- $a longitudinální studie $7 D008137
- 650 _2
- $a magnetická rezonanční tomografie $x metody $7 D008279
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a těhotenství $7 D011247
- 650 12
- $a zpožděný efekt prenatální expozice $7 D011297
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Marecek, Radek $u Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
- 700 1_
- $a Andrýsková, Lenka $u RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic $7 xx0302202
- 700 1_
- $a Brazdil, Milan $u Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
- 700 1_
- $a Nikolova, Yuliya S $u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: yuliya.nikolova@camh.ca
- 773 0_
- $w MED00209156 $t Biological psychiatry. Cognitive neuroscience and neuroimaging $x 2451-9030 $g Roč. 7, č. 2 (2022), s. 231-238
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34358683 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20230602101954 $b ABA008
- 999 __
- $a ok $b bmc $g 1788938 $s 1162293
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 7 $c 2 $d 231-238 $e 20210803 $i 2451-9030 $m Biological psychiatry. Cognitive neuroscience and neuroimaging $n Biol Psychiatry Cogn Neurosci Neuroimaging $x MED00209156
- LZP __
- $a Pubmed-20220425
