-
Je něco špatně v tomto záznamu ?
The Transgenerational Transmission of the Paternal Type 2 Diabetes-Induced Subfertility Phenotype
E. Zatecka, R. Bohuslavova, E. Valaskova, H. Margaryan, F. Elzeinova, A. Kubatova, S. Hylmarova, J. Peknicova, G. Pavlinkova
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, práce podpořená grantem
Free Medical Journals od 2010
PubMed Central od 2010
Europe PubMed Central od 2010
Open Access Digital Library od 2010-01-01
Open Access Digital Library od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
Odkazy
PubMed
34803926
DOI
10.3389/fendo.2021.763863
Knihovny.cz E-zdroje
- MeSH
- diabetes mellitus 2. typu krev chemicky indukované genetika MeSH
- dieta s vysokým obsahem tuků škodlivé účinky MeSH
- experimentální diabetes mellitus MeSH
- fenotyp * MeSH
- infertilita krev chemicky indukované genetika MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- paternální dědičnost účinky léků genetika MeSH
- spermie účinky léků fyziologie MeSH
- streptozocin toxicita MeSH
- těhotenství MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Diabetes is a chronic metabolic disorder characterized by hyperglycemia and associated with many health complications due to the long-term damage and dysfunction of various organs. A consequential complication of diabetes in men is reproductive dysfunction, reduced fertility, and poor reproductive outcomes. However, the molecular mechanisms responsible for diabetic environment-induced sperm damage and overall decreased reproductive outcomes are not fully established. We evaluated the effects of type 2 diabetes exposure on the reproductive system and the reproductive outcomes of males and their male offspring, using a mouse model. We demonstrate that paternal exposure to type 2 diabetes mediates intergenerational and transgenerational effects on the reproductive health of the offspring, especially on sperm quality, and on metabolic characteristics. Given the transgenerational impairment of reproductive and metabolic parameters through two generations, these changes likely take the form of inherited epigenetic marks through the germline. Our results emphasize the importance of improving metabolic health not only in women of reproductive age, but also in potential fathers, in order to reduce the negative impacts of diabetes on subsequent generations.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22011946
- 003
- CZ-PrNML
- 005
- 20220506130835.0
- 007
- ta
- 008
- 220425s2021 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3389/fendo.2021.763863 $2 doi
- 035 __
- $a (PubMed)34803926
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Zatecka, Eva $u Laboratory of Reproductive Biology, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 245 14
- $a The Transgenerational Transmission of the Paternal Type 2 Diabetes-Induced Subfertility Phenotype / $c E. Zatecka, R. Bohuslavova, E. Valaskova, H. Margaryan, F. Elzeinova, A. Kubatova, S. Hylmarova, J. Peknicova, G. Pavlinkova
- 520 9_
- $a Diabetes is a chronic metabolic disorder characterized by hyperglycemia and associated with many health complications due to the long-term damage and dysfunction of various organs. A consequential complication of diabetes in men is reproductive dysfunction, reduced fertility, and poor reproductive outcomes. However, the molecular mechanisms responsible for diabetic environment-induced sperm damage and overall decreased reproductive outcomes are not fully established. We evaluated the effects of type 2 diabetes exposure on the reproductive system and the reproductive outcomes of males and their male offspring, using a mouse model. We demonstrate that paternal exposure to type 2 diabetes mediates intergenerational and transgenerational effects on the reproductive health of the offspring, especially on sperm quality, and on metabolic characteristics. Given the transgenerational impairment of reproductive and metabolic parameters through two generations, these changes likely take the form of inherited epigenetic marks through the germline. Our results emphasize the importance of improving metabolic health not only in women of reproductive age, but also in potential fathers, in order to reduce the negative impacts of diabetes on subsequent generations.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a experimentální diabetes mellitus $7 D003921
- 650 _2
- $a diabetes mellitus 2. typu $x krev $x chemicky indukované $x genetika $7 D003924
- 650 _2
- $a dieta s vysokým obsahem tuků $x škodlivé účinky $7 D059305
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a infertilita $x krev $x chemicky indukované $x genetika $7 D007246
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši inbrední C57BL $7 D008810
- 650 _2
- $a paternální dědičnost $x účinky léků $x genetika $7 D000072740
- 650 12
- $a fenotyp $7 D010641
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a spermie $x účinky léků $x fyziologie $7 D013094
- 650 _2
- $a streptozocin $x toxicita $7 D013311
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Bohuslavova, Romana $u Laboratory of Molecular Pathogenetics, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 700 1_
- $a Valaskova, Eliska $u Laboratory of Reproductive Biology, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 700 1_
- $a Margaryan, Hasmik $u Laboratory of Reproductive Biology, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 700 1_
- $a Elzeinova, Fatima $u Laboratory of Reproductive Biology, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 700 1_
- $a Kubatova, Alena $u Laboratory of Reproductive Biology, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 700 1_
- $a Hylmarova, Simona $u Laboratory of Molecular Pathogenetics, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia $u Department of Internal Medicine, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia
- 700 1_
- $a Peknicova, Jana $u Laboratory of Reproductive Biology, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 700 1_
- $a Pavlinkova, Gabriela $u Laboratory of Molecular Pathogenetics, Institute of Biotechnology Czech Academy of Sciences (CAS), Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV), Vestec, Czechia
- 773 0_
- $w MED00174543 $t Frontiers in endocrinology $x 1664-2392 $g Roč. 12, č. - (2021), s. 763863
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34803926 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220506130827 $b ABA008
- 999 __
- $a ok $b bmc $g 1789506 $s 1163147
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 12 $c - $d 763863 $e 20211105 $i 1664-2392 $m Frontiers in endocrinology $n Front. endocrinol. $x MED00174543
- LZP __
- $a Pubmed-20220425