Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression

T. Horak, M. Horakova, A. Svatkova, Z. Kadanka, P. Kudlicka, J. Valosek, T. Rohan, M. Kerkovsky, E. Vlckova, Z. Kadanka, DK. Deelchand, PG. Henry, J. Bednarik, P. Bednarik

. 2021 ; 38 (21) : 2999-3010. [pub] 20211101

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22012000

Grantová podpora
P30 NS076408 NINDS NIH HHS - United States
P41 EB027061 NIBIB NIH HHS - United States

E-zdroje Online Plný text

NLK ProQuest Central od 2000-08-01 do 2021-02-15
Nursing & Allied Health Database (ProQuest) od 2000-08-01 do 2021-02-15
Health & Medicine (ProQuest) od 2000-08-01 do 2021-02-15
Psychology Database (ProQuest) od 2000-08-01 do 2021-02-15

Odkazy

PubMed 34428934
DOI 10.1089/neu.2021.0151
Knihovny.cz E-zdroje

Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and -14%) and SC (+12%, +46%, and -8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (-0.376 < r < -0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = -0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22012000
003      
CZ-PrNML
005      
20220506130335.0
007      
ta
008      
220425s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1089/neu.2021.0151 $2 doi
035    __
$a (PubMed)34428934
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Horak, Tomas $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Neurology, University Hospital Brno, Brno, Czechia $u Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czechia
245    10
$a In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression / $c T. Horak, M. Horakova, A. Svatkova, Z. Kadanka, P. Kudlicka, J. Valosek, T. Rohan, M. Kerkovsky, E. Vlckova, Z. Kadanka, DK. Deelchand, PG. Henry, J. Bednarik, P. Bednarik
520    9_
$a Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on state-of-the-art proton magnetic resonance spectroscopy (1H-MRS). Proton-MRS data were prospectively acquired from 73 participants with CSC compression and 47 healthy controls (HCs). The MRS voxel was centered at the C2 level. Compression-affected participants were clinically categorized as NMDC and DCM, radiologically as mild (MC) or severe (SC) compression. CSC volumes and neurochemical concentrations were compared between cohorts (HC vs. NMDC vs. DCM and HC vs. MC vs. SC) with general linear models adjusted for age and height (pFWE < 0.05) and correlated to stenosis severity, electrophysiology, and myelopathy symptoms (p < 0.05). Whereas the ratio of total creatine (tCr) to total N-acetylaspartate (tNAA) increased in NMDC (+11%) and in DCM (+26%) and SC (+21%), myo-inositol/tNAA, glutamate + glutamine/tNAA, and volumes changed only in DCM (+20%, +73%, and -14%) and SC (+12%, +46%, and -8%, respectively) relative to HCs. Both tCr/tNAA and myo-inositol/tNAA correlated with compression severity and volume (-0.376 < r < -0.259). Myo-inositol/tNAA correlated with myelopathy symptoms (r = -0.670), whereas CSC volume did not. Short-echo 1H-MRS provided neurochemical signatures of CSC impairment that reflected compression severity and clinical significance. Whereas volumetry only reflected clinically manifest myelopathy (DCM), MRS detected neurochemical changes already before the onset of myelopathy symptoms.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a kyselina asparagová $x analogy a deriváty $x metabolismus $7 D001224
650    _2
$a studie případů a kontrol $7 D016022
650    12
$a krční mícha $7 D066193
650    _2
$a krční obratle $7 D002574
650    _2
$a kreatin $x metabolismus $7 D003401
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a kyselina glutamová $x metabolismus $7 D018698
650    _2
$a lidé $7 D006801
650    _2
$a inositol $x metabolismus $7 D007294
650    12
$a magnetická rezonanční spektroskopie $7 D009682
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a senzitivita a specificita $7 D012680
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a komprese míchy $x metabolismus $x patologie $7 D013117
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Horakova, Magda $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Neurology, University Hospital Brno, Brno, Czechia $u Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czechia
700    1_
$a Svatkova, Alena $u Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria $u Department of Imaging Methods, Faculty of Medicine, University of Ostrava, Czechia
700    1_
$a Kadanka, Zdenek $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Neurology, University Hospital Brno, Brno, Czechia
700    1_
$a Kudlicka, Petr $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czechia
700    1_
$a Valosek, Jan $u Department of Neurology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czechia $u Department of Biomedical Engineering, University Hospital, Olomouc, Czechia
700    1_
$a Rohan, Tomas $u Department of Radiology, University Hospital Brno, Brno, Czechia
700    1_
$a Kerkovsky, Milos $u Department of Radiology, University Hospital Brno, Brno, Czechia
700    1_
$a Vlckova, Eva $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Neurology, University Hospital Brno, Brno, Czechia $u Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czechia
700    1_
$a Kadanka, Zdenek $u Department of Neurology, University Hospital Brno, Brno, Czechia
700    1_
$a Deelchand, Dinesh K $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA
700    1_
$a Henry, Pierre-Gilles $u Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA
700    1_
$a Bednarik, Josef $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Neurology, University Hospital Brno, Brno, Czechia $u Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czechia
700    1_
$a Bednarik, Petr $u Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czechia $u Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria
773    0_
$w MED00007057 $t Journal of neurotrauma $x 1557-9042 $g Roč. 38, č. 21 (2021), s. 2999-3010
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34428934 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20220506130327 $b ABA008
999    __
$a ok $b bmc $g 1789545 $s 1163201
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 38 $c 21 $d 2999-3010 $e 20211101 $i 1557-9042 $m Journal of neurotrauma $n J Neurotrauma $x MED00007057
GRA    __
$a P30 NS076408 $p NINDS NIH HHS $2 United States
GRA    __
$a P41 EB027061 $p NIBIB NIH HHS $2 United States
LZP    __
$a Pubmed-20220425

Najít záznam

Citační ukazatele

Možnosti archivace