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Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals
SR. McWhinney, C. Abé, M. Alda, F. Benedetti, E. Bøen, C. Del Mar Bonnin, T. Borgers, K. Brosch, EJ. Canales-Rodríguez, DM. Cannon, U. Dannlowski, AM. Díaz-Zuluaga, T. Elvsåshagen, LT. Eyler, JM. Fullerton, JM. Goikolea, J. Goltermann, D....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
P20 GM121312
NIGMS NIH HHS - United States
T32 AG058507
NIA NIH HHS - United States
U54 EB020403
NIBIB NIH HHS - United States
R21 MH113871
NIMH NIH HHS - United States
R01 MH090553
NIMH NIH HHS - United States
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- amygdala MeSH
- bipolární porucha * MeSH
- index tělesné hmotnosti MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mozek MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Neurology Division of Clinical Neuroscience Oslo University Hospital Oslo Norway
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry and Psychotherapy Philipps University Marburg Marburg Germany
Department of Psychiatry and Psychotherapy University of Bonn Bonn Germany
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Erasmus University Medical Center Rotterdam The Netherlands
Department of Psychiatry University of California San Diego La Jolla CA USA
Department of Psychiatry University of Münster Münster Germany
Desert Pacific MIRECC VA San Diego Healthcare San Diego CA USA
FIDMAG Germanes Hospitalàries Research Foundation Barcelona Spain
Institute of Clinical Medicine Department of Neurology University of Oslo Oslo Norway
Institute of Clinical Medicine University of Oslo Oslo Norway
Institute of Psychiartry King's College Londen London UK
Laureate Institute for Brain Research Tulsa OK USA
National Institute of Mental Health Klecany Czech Republic
Neuroscience Institute University of Cape Town Cape Town South Africa
Neuroscience Research Australia Randwick NSW Australia
Oxley College of Health Sciences The University of Tulsa Tulsa OK USA
Research Group Instituto de Alta Tecnología Médica Ayudas diagnósticas SURA Medellín Colombia
School of Medical Sciences University of New South Wales Sydney NSW Australia
School of Psychiatry University of New South Wales Sydney NSW Australia
UCLA Center for Neurobehavioral Genetics Los Angeles CA USA
University of British Columbia Vancouver BC Canada
Vita Salute San Raffaele University Milan Italy
West Region Institute of Mental Health Singapore Singapore
Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
Citace poskytuje Crossref.org
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- $a Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals / $c SR. McWhinney, C. Abé, M. Alda, F. Benedetti, E. Bøen, C. Del Mar Bonnin, T. Borgers, K. Brosch, EJ. Canales-Rodríguez, DM. Cannon, U. Dannlowski, AM. Díaz-Zuluaga, T. Elvsåshagen, LT. Eyler, JM. Fullerton, JM. Goikolea, J. Goltermann, D. Grotegerd, BCM. Haarman, T. Hahn, FM. Howells, M. Ingvar, TTJ. Kircher, A. Krug, RT. Kuplicki, M. Landén, H. Lemke, B. Liberg, C. Lopez-Jaramillo, UF. Malt, FM. Martyn, E. Mazza, C. McDonald, G. McPhilemy, S. Meier, S. Meinert, T. Meller, EMT. Melloni, PB. Mitchell, L. Nabulsi, I. Nenadic, N. Opel, RA. Ophoff, BJ. Overs, JK. Pfarr, JA. Pineda-Zapata, E. Pomarol-Clotet, J. Raduà, J. Repple, M. Richter, KG. Ringwald, G. Roberts, R. Salvador, J. Savitz, S. Schmitt, PR. Schofield, K. Sim, DJ. Stein, F. Stein, HS. Temmingh, K. Thiel, NEM. van Haren, HV. Gestel, C. Vargas, E. Vieta, A. Vreeker, L. Waltemate, LN. Yatham, CRK. Ching, O. Andreassen, PM. Thompson, T. Hajek, ENIGMA Bipolar Disorders Working Group
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