Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study

M. Martinez, ER. Perito, P. Valentino, CL. Mack, M. Aumar, A. Broderick, LG. Draijer, EDT. Fagundes, KN. Furuya, N. Gupta, S. Horslen, MM. Jonas, BM. Kamath, N. Kerkar, KM. Kim, KL. Kolho, BGP. Koot, TJ. Laborda, CK. Lee, KM. Loomes, T. Miloh, D....

. 2021 ; 74 (4) : 2047-2057. [pub] 20210909

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, pozorovací studie, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22012146

Grantová podpora
KL2 TR001065 NCATS NIH HHS - United States
UL1 TR001863 NCATS NIH HHS - United States
TL1 TR001066 NCATS NIH HHS - United States
UL1 TR000105 NCATS NIH HHS - United States
UL1 TR001067 NCATS NIH HHS - United States

BACKGROUND AND AIMS: Recurrent primary sclerosing cholangitis (rPSC) following liver transplant (LT) has a negative impact on graft and patient survival; little is known about risk factors for rPSC or disease course in children. APPROACH AND RESULTS: We retrospectively evaluated risk factors for rPSC in 140 children from the Pediatric PSC Consortium, a multicenter international registry. Recipients underwent LT for PSC and had >90 days of follow-up. The primary outcome, rPSC, was defined using Graziadei criteria. Median follow-up after LT was 3 years (interquartile range 1.1-6.1). rPSC occurred in 36 children, representing 10% and 27% of the subjects at 2 years and 5 years following LT, respectively. Subjects with rPSC were younger at LT (12.9 vs. 16.2 years), had faster progression from PSC diagnosis to LT (2.5 vs. 4.1 years), and had higher alanine aminotransferase (112 vs. 66 IU/L) at LT (all P < 0.01). Inflammatory bowel disease was more prevalent in the rPSC group (86% vs. 66%; P = 0.025). After LT, rPSC subjects had more episodes of biopsy-proved acute rejection (mean 3 vs. 1; P < 0.001), and higher prevalence of steroid-refractory rejection (41% vs. 20%; P = 0.04). In those with rPSC, 43% developed complications of portal hypertension, were relisted for LT, or died within 2 years of the diagnosis. Mortality was higher in the rPSC group (11.1% vs. 2.9%; P = 0.05). CONCLUSIONS: The incidence of rPSC in this cohort was higher than previously reported, and was associated with increased morbidity and mortality. Patients with rPSC appeared to have a more aggressive, immune-reactive phenotype. These findings underscore the need to understand the immune mechanisms of rPSC, to lay the foundation for developing new therapies and improve outcomes in this challenging population.

Department of Medicine Teikyo University School of Medicine Tokyo Japan

Department of Pediatrics Amsterdam University Medical Center Amsterdam Amsterdam the Netherlands

Department of Pediatrics Amsterdam University Medical Center Amsterdam the Netherlands

Department of Pediatrics Boston Children's Hospital and Harvard Medical School Boston MA

Department of Pediatrics Boston Children's Hospital Boston MA

Department of Pediatrics Children's Health Ireland at Crumlin and University College Dublin Dublin Ireland

Department of Pediatrics Children's Hospital at Montefiore Albert Einstein College of Medicine Bronx NY

Department of Pediatrics Children's Hospital of Philadelphia Philadelphia PA

Department of Pediatrics Children's Hospital of Pittsburgh at UPMC Pittsburgh PA

Department of Pediatrics Columbia University Irving Medical Center New York NY

Department of Pediatrics Emory University School of Medicine Atlanta GA

Department of Pediatrics Faculdade de Medicina da UFMG Belo Horizonte Brazil

Department of Pediatrics Faculty of Medicine and Health Sciences UJK Kielce former IP CZD Warsaw Poland

Department of Pediatrics Federal University of Minas Gerais Belo Horizonte Brazil

Department of Pediatrics Indiana University Indianapolis IN

Department of Pediatrics Johns Hopkins University Baltimore MD

Department of Pediatrics Lurie Children's Hospital Chicago IL

Department of Pediatrics Mayo Clinic Rochester MN

Department of Pediatrics Medical College of Wisconsin Milwaukee WI

Department of Pediatrics Palacky University Olomouc Czech Republic

Department of Pediatrics Texas Children Hospital Houston TX

Department of Pediatrics University of California San Diego San Diego CA

Department of Pediatrics University of California San Francisco San Francisco CA

Department of Pediatrics University of Colorado School of Medicine Aurora CO

Department of Pediatrics University of Miami Miami FL

Department of Pediatrics University of Rochester Medical Center Rochester NY

Department of Pediatrics University of Toronto Toronto ON Canada

Department of Pediatrics University of Ulsan Seoul South Korea

Department of Pediatrics University of Utah and Intermountain Primary Children's Hospital Salt Lake City UT

Department of Pediatrics University of Washington Seattle WA

Department of Pediatrics Yale University School of Medicine New Haven CT

Faculty of Medicine and Health Technology University of Helsinki Hospital and Tampere University Helsinki Finland

Institute for Translational Research in Inflammation University of Lille CHU Lille Lille France

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22012146
003      
CZ-PrNML
005      
20220506130521.0
007      
ta
008      
220425s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/hep.31911 $2 doi
035    __
$a (PubMed)34008252
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Martinez, Mercedes $u Department of Pediatrics, Columbia University Irving Medical Center, New York, NY $1 https://orcid.org/0000000161280155
245    10
$a Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study / $c M. Martinez, ER. Perito, P. Valentino, CL. Mack, M. Aumar, A. Broderick, LG. Draijer, EDT. Fagundes, KN. Furuya, N. Gupta, S. Horslen, MM. Jonas, BM. Kamath, N. Kerkar, KM. Kim, KL. Kolho, BGP. Koot, TJ. Laborda, CK. Lee, KM. Loomes, T. Miloh, D. Mogul, S. Mohammed, N. Ovchinsky, G. Rao, A. Ricciuto, A. Rodrigues Ferreira, KB. Schwarz, V. Smolka, A. Tanaka, MEM. Tessier, VL. Venkat, BE. Vitola, M. Woynarowski, M. Zerofsky, MR. Deneau
520    9_
$a BACKGROUND AND AIMS: Recurrent primary sclerosing cholangitis (rPSC) following liver transplant (LT) has a negative impact on graft and patient survival; little is known about risk factors for rPSC or disease course in children. APPROACH AND RESULTS: We retrospectively evaluated risk factors for rPSC in 140 children from the Pediatric PSC Consortium, a multicenter international registry. Recipients underwent LT for PSC and had >90 days of follow-up. The primary outcome, rPSC, was defined using Graziadei criteria. Median follow-up after LT was 3 years (interquartile range 1.1-6.1). rPSC occurred in 36 children, representing 10% and 27% of the subjects at 2 years and 5 years following LT, respectively. Subjects with rPSC were younger at LT (12.9 vs. 16.2 years), had faster progression from PSC diagnosis to LT (2.5 vs. 4.1 years), and had higher alanine aminotransferase (112 vs. 66 IU/L) at LT (all P < 0.01). Inflammatory bowel disease was more prevalent in the rPSC group (86% vs. 66%; P = 0.025). After LT, rPSC subjects had more episodes of biopsy-proved acute rejection (mean 3 vs. 1; P < 0.001), and higher prevalence of steroid-refractory rejection (41% vs. 20%; P = 0.04). In those with rPSC, 43% developed complications of portal hypertension, were relisted for LT, or died within 2 years of the diagnosis. Mortality was higher in the rPSC group (11.1% vs. 2.9%; P = 0.05). CONCLUSIONS: The incidence of rPSC in this cohort was higher than previously reported, and was associated with increased morbidity and mortality. Patients with rPSC appeared to have a more aggressive, immune-reactive phenotype. These findings underscore the need to understand the immune mechanisms of rPSC, to lay the foundation for developing new therapies and improve outcomes in this challenging population.
650    _2
$a mladiství $7 D000293
650    _2
$a věkové faktory $7 D000367
650    _2
$a alanintransaminasa $x krev $7 D000410
650    _2
$a aspartátaminotransferasy $x krev $7 D001219
650    _2
$a dítě $7 D002648
650    _2
$a sklerozující cholangitida $x krev $x epidemiologie $x chirurgie $7 D015209
650    _2
$a progrese nemoci $7 D018450
650    _2
$a léková rezistence $7 D004351
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a glukokortikoidy $x terapeutické užití $7 D005938
650    _2
$a rejekce štěpu $x farmakoterapie $x epidemiologie $x patologie $7 D006084
650    _2
$a přežívání štěpu $7 D006085
650    _2
$a lidé $7 D006801
650    _2
$a portální hypertenze $x epidemiologie $x patofyziologie $7 D006975
650    _2
$a idiopatické střevní záněty $x epidemiologie $7 D015212
650    _2
$a internacionalita $7 D038622
650    12
$a transplantace jater $7 D016031
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a recidiva $7 D012008
650    _2
$a registrace $7 D012042
650    _2
$a rizikové faktory $7 D012307
650    _2
$a časové faktory $7 D013997
650    _2
$a gama-glutamyltransferasa $x krev $7 D005723
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Perito, Emily R $u Department of Pediatrics, University of California, San Francisco, San Francisco, CA
700    1_
$a Valentino, Pamela $u Department of Pediatrics, Yale University School of Medicine, New Haven, CT $1 https://orcid.org/0000000282272004
700    1_
$a Mack, Cara L $u Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO
700    1_
$a Aumar, Madeleine $u Institute for Translational Research in Inflammation, University of Lille, CHU Lille, Lille, France $1 https://orcid.org/0000000229086931
700    1_
$a Broderick, Annemarie $u Department of Pediatrics, Children's Health Ireland at Crumlin & University College Dublin, Dublin, Ireland
700    1_
$a Draijer, Laura G $u Department of Pediatrics, Amsterdam University Medical Center, Amsterdam, the Netherlands
700    1_
$a Fagundes, Eleonora D T $u Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Brazil
700    1_
$a Furuya, Katryn N $u Department of Pediatrics, Mayo Clinic, Rochester, MN $u Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
700    1_
$a Gupta, Nitika $u Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
700    1_
$a Horslen, Simon $u Department of Pediatrics, University of Washington, Seattle, WA
700    1_
$a Jonas, Maureen M $u Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA
700    1_
$a Kamath, Binita M $u Department of Pediatrics, University of Toronto, Toronto, ON, Canada
700    1_
$a Kerkar, Nanda $u Department of Pediatrics, University of Rochester Medical Center, Rochester, NY
700    1_
$a Kim, Kyung Mo $u Department of Pediatrics, University of Ulsan, Seoul, South Korea
700    1_
$a Kolho, Kaija-Leena $u Faculty of Medicine and Health Technology, University of Helsinki Hospital and Tampere University, Helsinki, Finland
700    1_
$a Koot, Bart G P $u Department of Pediatrics, Amsterdam University Medical Center Amsterdam, Amsterdam, the Netherlands
700    1_
$a Laborda, Trevor J $u Department of Pediatrics, University of Utah and Intermountain Primary Children's Hospital, Salt Lake City, UT
700    1_
$a Lee, Christine K $u Department of Pediatrics, Boston Children's Hospital, Boston, MA
700    1_
$a Loomes, Kathleen M $u Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
700    1_
$a Miloh, Tamir $u Department of Pediatrics, University of Miami, Miami, FL
700    1_
$a Mogul, Douglas $u Department of Pediatrics, Johns Hopkins University, Baltimore, MD
700    1_
$a Mohammed, Saeed $u Department of Pediatrics, Lurie Children's Hospital, Chicago, IL $1 https://orcid.org/0000000229502552
700    1_
$a Ovchinsky, Nadia $u Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY $1 https://orcid.org/0000000215281680
700    1_
$a Rao, Girish $u Department of Pediatrics, Indiana University, Indianapolis, IN
700    1_
$a Ricciuto, Amanda $u Department of Pediatrics, University of Toronto, Toronto, ON, Canada $1 https://orcid.org/0000000195383005
700    1_
$a Rodrigues Ferreira, Alexandre $u Department of Pediatrics, Faculdade de Medicina da UFMG, Belo Horizonte, Brazil
700    1_
$a Schwarz, Kathleen B $u Department of Pediatrics, University of California San Diego, San Diego, CA $u Department of Pediatrics, Johns Hopkins University, Baltimore, MD
700    1_
$a Smolka, Vratislav $u Department of Pediatrics, Palacky University, Olomouc, Czech Republic
700    1_
$a Tanaka, Atsushi $u Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
700    1_
$a Tessier, Mary E M $u Department of Pediatrics, Texas Children Hospital, Houston, TX
700    1_
$a Venkat, Venna L $u Department of Pediatrics, Children's Hospital of Pittsburgh at UPMC, Pittsburgh, PA
700    1_
$a Vitola, Bernadette E $u Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
700    1_
$a Woynarowski, Marek $u Department of Pediatrics, Faculty of Medicine and Health Sciences, UJK Kielce, former IP CZD Warsaw, Poland
700    1_
$a Zerofsky, Melissa $u Department of Pediatrics, University of California San Francisco, San Francisco, CA
700    1_
$a Deneau, Mark R $u Department of Pediatrics, University of Utah and Intermountain Primary Children's Hospital, Salt Lake City, UT $1 https://orcid.org/0000000304599404
773    0_
$w MED00009806 $t Hepatology (Baltimore, Md.) $x 1527-3350 $g Roč. 74, č. 4 (2021), s. 2047-2057
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34008252 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20220506130513 $b ABA008
999    __
$a ok $b bmc $g 1789650 $s 1163347
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 74 $c 4 $d 2047-2057 $e 20210909 $i 1527-3350 $m Hepatology $n Hepatology $x MED00009806
GRA    __
$a KL2 TR001065 $p NCATS NIH HHS $2 United States
GRA    __
$a UL1 TR001863 $p NCATS NIH HHS $2 United States
GRA    __
$a TL1 TR001066 $p NCATS NIH HHS $2 United States
GRA    __
$a UL1 TR000105 $p NCATS NIH HHS $2 United States
GRA    __
$a UL1 TR001067 $p NCATS NIH HHS $2 United States
LZP    __
$a Pubmed-20220425

Najít záznam

Citační ukazatele

Možnosti archivace